Literature summary for 3.3.2.10 extracted from

De Taeye, B.; Morisseau, C.; Coyle, J.; Covington, J.; Luria, A.; Yang, J.; Murphy, S.; Friedman, D.; Hammock, B.; Vaughan, D.
Expression and regulation of soluble epoxide hydrolase in adipose tissue (2010), Obesity (Silver Spring), 18, 489-498.

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Application

Application	Comment	Organism
medicine	sEH is synthesized in adipocytes and expression levels increase upon differentiation of 3T3-L1 preadipocytes. Although normalized sEH mRNA and protein levels do not differ in the fat pads from mice receiving a regular or a high-fat diet, total adipose sEH activity is higher in the obese mice. Peroxisome proliferator-activated receptor gamma agonists increase the expression of sEH in mature 3T3-L1 adipocytes in vitro and in adipose tissue in vivo	Mus musculus

Organism

Organism	UniProt	Comment	Textmining
Mus musculus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
adipocyte	sEH is synthesized in adipocytes and expression levels increase upon differentiation of 3T3-L1 preadipocytes. Although normalized sEH mRNA and protein levels do not differ in the fat pads from mice receiving a regular or a high-fat diet, total adipose sEH activity is higher in the obese mice. Peroxisome proliferator-activated receptor gamma agonists increase the expression of sEH in mature 3T3-L1 adipocytes in vitro and in adipose tissue in vivo	Mus musculus	-

Expression

Organism	Comment	Expression
Mus musculus	sEH is synthesized in adipocytes and expression levels increase upon differentiation of 3T3-L1 preadipocytes. Peroxisome proliferator-activated receptor gamma agonists increase the expression of sEH in mature 3T3-L1 adipocytes in vitro and in adipose tissue in vivo	up

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Release 2023.1 (January 2023)