Literature summary for 3.3.2.10 extracted from

Zhang, D.; Ai, D.; Tanaka, H.; Hammock, B.D.; Zhu, Y.
DNA methylation of the promoter of soluble epoxide hydrolase silences its expression by an SP-1-dependent mechanism (2010), Biochim. Biophys. Acta, 1799, 659-667.

Search for more literature for 3.3.2.10

Application

Application	Comment	Organism
medicine	relative expression of sEH is lower at both the mRNAand protein levels in HepG2 cells than in other cells with the same amount of total RNA or protein loaded. Transcription factor SP-1 is involved in the decrease in the transcription of sEH as a result of DNA methylation in HepG2 cells, which might contribute to epigenetic mechanism-induced carcinogenesis in hepatocytes	Homo sapiens

Cloned(Commentary)

Cloned (Comment)	Organism
-	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Expression

Organism	Comment	Expression
Homo sapiens	relative expression of sEH is lower at both the mRNAand protein levels in HepG2 cells than in other cells with the same amount of total RNA or protein loaded. Transcription factor SP-1 is involved in the decrease in the transcription of sEH as a result of DNA methylation in HepG2 cells, which might contribute to epigenetic mechanism-induced carcinogenesis in hepatocytes	down

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)