Any feedback?
Literature summary for 3.3.2.10 extracted from
- Soluble epoxide hydrolase in atherosclerosis (2010), Curr. Atheroscler. Rep., 12, 174-183.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene Ephx2, located on chromosome 8p21-p12 | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| C780T | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
| G1465A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
| G405A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
| G560A | naturally occuring mutation involved in renal cortex of Wistar-Kyoto rats | Rattus norvegicus |
| additional information | increased sEH gene expression and activity along with renal eicosanoid metabolism participate in the pathogenesis of hypertension in SHRs | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea | i.e. AR9276, reduces atherosclerotic lesions in the aorta and carotid artery and attenuates abdominal aortic aneurysm formation in apolipoprotein E-deficient mice | Mus musculus |  |
| 1-(1-nicotinoylpiperidin-4-yl)-3-(4-(trifluoromethoxy) phenyl) urea | i.e. AR9276 | Rattus norvegicus | |
| 1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea | - |
Mus musculus | |
| 1-adamantan-3-(5-(2-(2-ethylethoxy) ethoxy)pentyl) urea | - |
Rattus norvegicus | |
| additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Mus musculus | |
| additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| soluble | - |
Mus musculus | - |
- |
| soluble | - |
Homo sapiens | - |
- |
| soluble | - |
Rattus norvegicus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Homo sapiens | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P34913 | gene EPHX2 | - |
| Mus musculus | P34914 | - |
- |
| Rattus norvegicus | P80299 | Wistar-Kyoto rats and Sprague-Dawley rats | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| aorta | - |
Mus musculus | - |
| blood vessel | - |
Homo sapiens | - |
| carotid artery | - |
Mus musculus | - |
| kidney | - |
Mus musculus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| liver | - |
Mus musculus | - |
| liver | - |
Homo sapiens | - |
| liver | laboratory rats have by far the lowest levels of hepatic sEH among the mammals studied | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Homo sapiens | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
| (5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | i.e. EETs, showing endothelium-derived hyperpolarizing factor effects dominating in microvessels independent of nitric oxide and prostacyclin. sEH reduces the beneficial effects of EETs | Rattus norvegicus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| SEH | - |
Mus musculus |
| SEH | - |
Homo sapiens |
| SEH | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Mus musculus |
| malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Homo sapiens |
| malfunction | association of sEH gene Ephx2 polymorphisms with increased risk of atherosclerosis and cardiovascular diseases, role of epoxyeicosatrienoic acids, EETs, and sEH in the pathogenesis of atherosclerosis, overview | Rattus norvegicus |
| additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Mus musculus |
| additional information | treatment with sEH inhibitors reduces blood pressure in several animal models of hypertension | Rattus norvegicus |
Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.
Release 2023.1 (January 2023)
Legal
Curated at
Member of
