Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | sEH inhibitors are 1,3-disubstituted ureas, amides and carbamates that have IC50-values in the low nanomolar range. They only block the hydrolase activity of the enzyme without affecting the phosphatase domain | Mammalia |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mammalia | - |
- |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
62000 | - |
2 * 62000 | Mammalia |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mammalia | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mammalia | - |
kidney | - |
Mammalia | - |
additional information | sEH is ubiquituously expressed | Mammalia | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme possesses an epoxide hydrolyzing as well as a lipid phosphatase activity. Favored sEH substrates are trans-substituted over cis-substituted epoxides | Mammalia | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
homodimer | 2 * 62000 | Mammalia |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mammalia |
General Information | Comment | Organism |
---|---|---|
additional information | sEh inhibition reduces inflammation. In several mouse models, sEH inhibition reduces atherosclerosis and aortic aneurysm formation. The anti-proliferative effect of urea-based sEH inhibitors is probably caused by PPARa activation and consecutive inhibition of cyclin D1 expression. And sEH inhibition affects renal fucntions, overview | Mammalia |
physiological function | sEH is not essentially involved in the metabolization and clearance of carcinogenic xenobiotics. But sEH is involved in inflammation | Mammalia |