Protein Variants | Comment | Organism |
---|---|---|
additional information | male mice lacking the sEH gene had lower systolic blood pressure | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Homo sapiens | - |
- |
soluble | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview | ? | - |
? | |
additional information | Mus musculus | epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | P34914 | streptozotocin-induced diabetic mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
HEP-3B cell | - |
Homo sapiens | - |
kidney | - |
Homo sapiens | - |
kidney | distribution in proximal tubules but not in the glomerulus or other regions, immunohistochemic analysis | Mus musculus | - |
liver | - |
Homo sapiens | - |
liver | diabetes reduces the amount of sEH protein in the liver and insulin restored the level of protein | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview | Homo sapiens | ? | - |
? | |
additional information | epoxyeicosatrienoic acids are substrates of sEH, enzyme regulation, overview | Mus musculus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Homo sapiens |
SEH | - |
Mus musculus |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | high glucose and high concentration of reactive oxygen species suppresses sEH mRNA and protein expression in Hep-3B cells. Inhibition of NADPH oxidase inhibits the decrease in sEH by high glucose and the addition of hydrogen peroxide to Hep3B cells suppresses the expression of sEH | down |
Mus musculus | high glucose levels suppress sEH expression in diabetic mouse liver, which is reversible by insulin | down |
General Information | Comment | Organism |
---|---|---|
malfunction | diabetes is one of the main factors responsible for end-stage renal disease caused by impaired endothelium | Homo sapiens |
malfunction | diabetes is one of the main factors responsible for end-stage renal disease caused by impaired endothelium | Mus musculus |
physiological function | sEH is a xenobiotic-metabolizing enzyme that metabolizes epoxides to produce vicinal diols. Epoxyeicosatrienoic acids are substrates of sEH and have important roles in renal function such as ion transport and the proliferation of cells and the action of epoxyeicosatrienoic acids is important for maintaining renal and vascular homeostasis | Homo sapiens |
physiological function | sEH is a xenobiotic-metabolizing enzyme that metabolizes epoxides to produce vicinal diols. Epoxyeicosatrienoic acids are substrates of sEH and have important roles in renal function such as ion transport and the proliferation of cells and the action of epoxyeicosatrienoic acids is important for maintaining renal and vascular homeostasis | Mus musculus |