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Literature summary for 3.3.2.10 extracted from

  • Anandan, S.K.; Do, Z.N.; Webb, H.K.; Patel, D.V.; Gless, R.D.
    Non-urea functionality as the primary pharmacophore in soluble epoxide hydrolase inhibitors (2009), Bioorg. Med. Chem. Lett., 19, 1066-1070.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
1-cyclohexyl-3-[3-(3-morpholin-4-ylpropoxy)phenyl]urea
-
 Homo sapiens
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]thiourea
-
 Homo sapiens
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]urea
-
 Homo sapiens
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
-
 Homo sapiens
1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
-
 Homo sapiens
2-cyclohexyl-N-[3-(3-morpholin-4-ylpropoxy)phenyl]acetamide
-
 Homo sapiens
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
 Homo sapiens
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens
2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
 Homo sapiens
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
 Homo sapiens
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens
N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[4-(trifluoromethyl)phenyl]acetamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzenesulfonamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N'-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]sulfamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-ylmethyl]formamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]formamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]glycinamide
-
 Homo sapiens
N-[3-(3-morpholin-4-ylpropoxy)phenyl]cyclohexanecarboxamide
-
 Homo sapiens
N-[4-(benzyloxy)phenyl]-2-hydroxy-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
 Homo sapiens
N-[4-(benzyloxy)phenyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens
N-[4-(benzyloxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
-
 Homo sapiens
N-[4-(benzyloxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000008
-
-
 Homo sapiens 1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]urea
0.0000012
-
-
 Homo sapiens 1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethyl)phenyl]urea
0.0000025
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-ylmethyl]formamide
0.0000039
-
-
 Homo sapiens 1-cyclohexyl-3-[3-(3-morpholin-4-ylpropoxy)phenyl]urea
0.0000082
-
-
 Homo sapiens 1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[4-(trifluoromethoxy)phenyl]urea
0.000011
-
-
 Homo sapiens N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
0.000022
-
-
 Homo sapiens 1-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]thiourea
0.000023
-
-
 Homo sapiens 2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.000028
-
-
 Homo sapiens 2-cyclohexyl-N-[3-(3-morpholin-4-ylpropoxy)phenyl]acetamide
0.000048
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
0.000049
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.000055
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[4-(trifluoromethyl)phenyl]acetamide
0.000088
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]formamide
0.000093
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzamide
0.00011
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]glycinamide
0.000185
-
-
 Homo sapiens N-[2-[4-(benzyloxy)phenyl]ethyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.00021
-
-
 Homo sapiens N-[4-(benzyloxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
0.00027
-
-
 Homo sapiens N-[4-(benzyloxy)phenyl]-2-hydroxy-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.00031
-
-
 Homo sapiens N-[4-(benzyloxy)phenyl]-2-hydroxy-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
0.00039
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]cyclohexanecarboxamide
0.00053
-
-
 Homo sapiens 2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
0.000685
-
-
 Homo sapiens N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-4-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]butanamide
0.0011
-
-
 Homo sapiens N-[4-(benzyloxy)phenyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.00154
-
-
 Homo sapiens N-[2-[4-(benzyloxy)phenyl]ethyl]-2-oxo-3-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]propanamide
0.002
-
 IC50 above 0.02 mM Homo sapiens 2-hydroxy-N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
0.002
-
 IC50 above 0.02 mM Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-2-oxo-2-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]acetamide
0.0036
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-N'-[(3S,5S)-tricyclo[3.3.1.13,7]dec-1-yl]sulfamide
0.015
-
-
 Homo sapiens N-[3-(3-morpholin-4-ylpropoxy)phenyl]-4-(trifluoromethyl)benzenesulfonamide