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Literature summary for 3.3.2.10 extracted from

  • Imig, J.D.; Hammock, B.D.
    Soluble epoxide hydrolase as a therapeutic target for cardiovascular diseases (2009), Nat. Rev. Drug Discov., 8, 794-805.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
pharmacology the enzyme is a promising therapeutic strategy for cardiovascular disease Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
AUDA
-
 Homo sapiens
AUDA-BE
-
 Homo sapiens
additional information sEH inhibitors are developed to enhance the cardiovascular actions of epoxyeicosatrienoic acids, treatment potentials, cardiovascular therapeutic effects, antihypertensive effects, kidney-protective properties, cardiac-protective properties, and protection against ischaemic stroke and vascular disease of sEH inhibitors, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O Homo sapiens
-
 (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
additional information Homo sapiens Vascular actions and antiinflammatory actions of epoxyeicosatrienoic acids, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Homo sapiens
-
heart
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
lung
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid
-
 ?
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid
-
 ?
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O
-
 Homo sapiens (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid
-
 ?
additional information Vascular actions and antiinflammatory actions of epoxyeicosatrienoic acids, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism the enzyme is involved in the arachidonate cascade, pathways overview Homo sapiens
physiological function conversion of epoxyeicosatrienoic acids to their corresponding diols, dihydroxyeicosatrienoic acids, DHETS, by sEH is responsible for decreasing EET levels and thereby diminishing their beneficial cardiovascular properties, detailed overview Homo sapiens