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Literature summary for 3.3.2.10 extracted from

  • Taylor, S.J.; Soleymanzadeh, F.; Eldrup, A.B.; Farrow, N.A.; Muegge, I.; Kukulka, A.; Kabcenell, A.K.; De Lombaert, S.
    Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase (2009), Bioorg. Med. Chem. Lett., 19, 5864-5868.
    View publication on PubMed
Search for more literature for 3.3.2.10

Inhibitors

Inhibitors Comment Organism Structure
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
-
 Homo sapiens
6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
-
 Rattus norvegicus
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
-
 Homo sapiens
6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
-
 Rattus norvegicus
additional information design and synthesis of a series of potent nicotinamide inhibitors of soluble epoxides hydrolase, structure-guided optimization, overview Homo sapiens
additional information design and synthesis of a series of potent nicotinamide inhibitors of soluble epoxides hydrolase, structure-guided optimization, overview Rattus norvegicus
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Homo sapiens
N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Homo sapiens
N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Rattus norvegicus
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
 Homo sapiens
N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
 Rattus norvegicus
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Homo sapiens
N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Rattus norvegicus
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Homo sapiens
N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
-
 Rattus norvegicus
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
 Homo sapiens
N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
-
 Rattus norvegicus
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Homo sapiens
N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
-
 Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Homo sapiens P34913
-
-
Rattus norvegicus P80299
-
-

Synonyms

Synonyms Comment Organism
SEH
-
 Homo sapiens
SEH
-
 Rattus norvegicus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000026
-
-
 Homo sapiens N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000004
-
-
 Rattus norvegicus N-(3,3-diphenylpropyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.0000043
-
-
 Rattus norvegicus N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000046
-
-
 Homo sapiens N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000054
-
-
 Homo sapiens N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.000006
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000006
-
-
 Rattus norvegicus N-[2-(trifluoromethoxy)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000066
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.000007
-
-
 Rattus norvegicus N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000007
-
-
 Rattus norvegicus N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000073
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.0000078
-
-
 Rattus norvegicus N-(3,3-diphenylpropyl)-6-(2,2,2-trifluoroethoxy)pyridine-3-carboxamide
0.000008
-
-
 Rattus norvegicus N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0000081
-
-
 Homo sapiens N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.0000085
-
-
 Rattus norvegicus 6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
0.000009
-
-
 Rattus norvegicus N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
0.0000091
-
-
 Homo sapiens 6-amino-N-(3,3-diphenylpropyl)pyridine-3-carboxamide
0.00001
-
-
 Rattus norvegicus N-(3,3-diphenylpropyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000011
-
-
 Rattus norvegicus N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000012
-
-
 Homo sapiens N-[[4'-(methylsulfonyl)biphenyl-4-yl]methyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000012
-
-
 Homo sapiens N-(4-bromo-2-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000014
-
-
 Homo sapiens N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000014
-
-
 Homo sapiens N-(2-chloro-4-cyanobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000015
-
-
 Homo sapiens N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000016
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-1-(2-ethoxyethyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.000016
-
-
 Rattus norvegicus N-[2-chloro-4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000018
-
-
 Homo sapiens N-(3,3-diphenylpropyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
0.000019
-
-
 Rattus norvegicus N-[2-chloro-4-(methylsulfamoyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000021
-
-
 Homo sapiens N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000021
-
-
 Homo sapiens N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000022
-
-
 Rattus norvegicus N-(2-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000025
-
-
 Rattus norvegicus N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00005
-
-
 Rattus norvegicus N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000066
-
-
 Homo sapiens N-[4-chloro-2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.000077
-
-
 Homo sapiens N-(4-chlorobenzyl)-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00011
-
-
 Homo sapiens N-[4-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00016
-
-
 Rattus norvegicus N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00018
-
-
 Rattus norvegicus N-[2-chloro-4-(1H-tetrazol-5-yl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00027
-
-
 Homo sapiens N-[2-(methylsulfonyl)benzyl]-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.00033
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.0004
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide
0.00043
-
-
 Rattus norvegicus 6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
0.0005
-
-
 Rattus norvegicus N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide
0.00052
-
-
 Homo sapiens 6-amino-N-(2,4-dichlorobenzyl)pyridine-3-carboxamide
0.0012
-
-
 Homo sapiens N-benzyl-6-(3,3,3-trifluoropropoxy)pyridine-3-carboxamide
0.0015
-
-
 Homo sapiens N-(2,4-dichlorobenzyl)-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide