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Literature summary for 3.3.2.10 extracted from
- Leukotriene A4. Enzymatic conversion into 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid by mouse liver cytosolic epoxide hydrolase (1986), J. Biol. Chem., 261, 6332-6337.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | clofibrate induces the enzyme | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Mus musculus | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | Mus musculus | - |
5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| to homogeneity from liver by ultracentrifugation, ion exchange, hydrophobic interaction and hydroxyapatite chromatography | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| leukotriene A4 + H2O | - |
Mus musculus | 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid | - |
? | |
| leukotriene A4 + H2O | - |
Mus musculus | 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid | i.e. compound D, product identification by GC-MS | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Cytosolic epoxide hydrolase | - |
Mus musculus |
| More | see also EC 3.3.2.6 | Mus musculus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 80 | - |
10 min, cytosolic fraction, inactivation | Mus musculus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
assay at, cytosolic fraction | Mus musculus |
| 8 | - |
assay at, purified enzyme | Mus musculus |
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