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Literature summary for 3.3.2.10 extracted from

  • Ai, D.; Pang, W.; Li, N.; Xu, M.; Jones, P.D.; Yang, J.; Zhang, Y.; Chiamvimonvat, N.; Shyy, J.Y.; Hammock, B.D.; Zhu, Y.
    Soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy (2009), Proc. Natl. Acad. Sci. USA, 106, 564-569.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Activating Compound

Activating Compound Comment Organism Structure
additional information sEH is specifically up-regulated by angiotensin II Mus musculus
additional information sEH is specifically up-regulated by angiotensin II Rattus norvegicus

Application

Application Comment Organism
medicine soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy Mus musculus
medicine soluble epoxide hydrolase plays an essential role in angiotensin II-induced cardiac hypertrophy Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea 0.001 mM markedly inhibits the basal and angiotensin II-induced sEH activity Mus musculus
1-(1-methanesulfonyl-piperidin-4-yl)-3-(4-trifluoromethoxy-phenyl)-urea 0.001 mM markedly inhibits the basal and angiotensin II-induced sEH activity Rattus norvegicus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
cardiomyocyte
-
 Mus musculus
-
heart
-
 Rattus norvegicus
-

Synonyms

Synonyms Comment Organism
EPHX2
-
 Mus musculus
EPHX2
-
 Rattus norvegicus
SEH
-
 Mus musculus
SEH
-
 Rattus norvegicus