Application | Comment | Organism |
---|---|---|
medicine | the enzyme is a therapeutic target for control of blood pressure | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
N,N'-dicyclohexylurea | specific inhibitor, decreases the enzyme activity and blood pressure in spontaneously hypertensive rats, IC50 with different substrates, overview | Rattus norvegicus | |
N-cyclohexyl-N'-dodecylurea | weak inhibition | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Rattus norvegicus | 5829 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
cis-11,12-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | - |
? | - |
? | |
cis-14,15-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | - |
? | - |
? | |
cis-8,9-epoxyeicosatrienoic acid + H2O | Rattus norvegicus | - |
? | - |
? | |
additional information | Rattus norvegicus | the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats, the enzyme is involved in regulation of blood pressure | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
male spontaneously hypertensive rats and normotensive Wistar-Kyoto rats | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
kidney | the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats | Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
cis-11,12-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
cis-14,15-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
cis-8,9-epoxyeicosatrienoic acid + H2O | - |
Rattus norvegicus | ? | - |
? | |
additional information | the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats, the enzyme is involved in regulation of blood pressure | Rattus norvegicus | ? | - |
? | |
trans-1,3-diphenylpropene oxide + H2O | - |
Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Rattus norvegicus |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.026 | - |
N,N'-dicyclohexylurea | purified recombinant enzyme | Rattus norvegicus |