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Literature summary for 3.3.2.10 extracted from

  • Yu, Z.; Xu, F.; Huse, L.M.; Morisseau, C.; Draper, A.J.; Newman, J.W.; Parker, C.; Graham, L.; Engler, M.M.; Hammock, B.D.; Zeldin, D.C.; Kroetz, D.L.
    Soluble epoxide hydrolase regulates hydrolysis of vasoactive epoxyeicosatrienoic acids (2000), Circ. Res., 87, 992-998.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a therapeutic target for control of blood pressure Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
N,N'-dicyclohexylurea specific inhibitor, decreases the enzyme activity and blood pressure in spontaneously hypertensive rats, IC50 with different substrates, overview Rattus norvegicus
N-cyclohexyl-N'-dodecylurea weak inhibition Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
cis-11,12-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
?
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
?
-
?
cis-8,9-epoxyeicosatrienoic acid + H2O Rattus norvegicus
-
?
-
?
additional information Rattus norvegicus the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats, the enzyme is involved in regulation of blood pressure ?
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
male spontaneously hypertensive rats and normotensive Wistar-Kyoto rats
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats Rattus norvegicus
-
liver
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-11,12-epoxyeicosatrienoic acid + H2O
-
Rattus norvegicus ?
-
?
cis-14,15-epoxyeicosatrienoic acid + H2O
-
Rattus norvegicus ?
-
?
cis-8,9-epoxyeicosatrienoic acid + H2O
-
Rattus norvegicus ?
-
?
additional information the activity for epoxyeicosatrienoic acids is elevated 5 to 54fold in renal cortical S9 fraction from the spontaneously hypertensive rats compared to normotensive Wistar-Kyoto rats, the enzyme is involved in regulation of blood pressure Rattus norvegicus ?
-
?
trans-1,3-diphenylpropene oxide + H2O
-
Rattus norvegicus ?
-
?

Synonyms

Synonyms Comment Organism
SEH
-
Rattus norvegicus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.026
-
N,N'-dicyclohexylurea purified recombinant enzyme Rattus norvegicus