Cloned (Comment) | Organism |
---|---|
expression in baculoviral system | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
His-tagged hydrolase domain, in complex with inhibitor N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide. The compound binds deeply within the active site of sEH, forming a network of hydrogen-bonding interactionswith key protein atoms | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-(4-acetylphenyl)-N-(5-chloro-1,3-benzoxazol-2-yl)piperidine-4-carboxamide | IC50 value in COS-7 cell assay 4.7 nM, 45% remiaining stability in human microsomes | Homo sapiens | |
1-(4-acetylphenyl)-N-(5-methyl-1,3-benzoxazol-2-yl)piperidine-4-carboxamide | IC50 value in COS-7 cell assay 5.8 nM, 53% remiaining stability in human microsomes | Homo sapiens | |
N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide | - |
Homo sapiens | |
t-butyl 4-[2-[(5-chloro-1,3-benzoxazol-2-yl)amino]-2-oxoethyl]piperidine-1-carboxylate | IC50 value in COS-7 cell assay 1.5 nM, 43% remiaining stability in human microsomes | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P34913 | - |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
6,8-difluoro-4-methylumbelliferyl trans-2,3-epoxy-3-phenylpropylcarbonate + H2O | - |
Homo sapiens | ? | - |
? |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000036 | - |
pH 7.4, 22°C | Homo sapiens | 1-(4-acetylphenyl)-N-(5-chloro-1,3-benzoxazol-2-yl)piperidine-4-carboxamide | |
0.0000036 | - |
pH 7.4, 22°C | Homo sapiens | 1-(4-acetylphenyl)-N-(5-methyl-1,3-benzoxazol-2-yl)piperidine-4-carboxamide | |
0.0000069 | - |
pH 7.4, 22°C | Homo sapiens | t-butyl 4-[2-[(5-chloro-1,3-benzoxazol-2-yl)amino]-2-oxoethyl]piperidine-1-carboxylate | |
0.000032 | - |
pH 7.4, 22°C | Homo sapiens | N-(5-chloro-1,3-benzoxazol-2-yl)-2-cyclopentylacetamide |