Literature summary for 3.3.2.10 extracted from

Yu, Z.; Davis, B.B.; Morisseau, C.; Hammock, B.D.; Olson, J.L.; Kroetz, D.L.; Weiss, R.H.
Vascular localization of soluble epoxide hydrolase in the human kidney (2004), Am. J. Physiol., 286, F720-726.

Search for more literature for 3.3.2.10

Application

Application	Comment	Organism
medicine	the enzyme is a therapeutic target in therapeutic intervention in renal hydrodynamic regulation and blood pressure control	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Homo sapiens	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
epoxyeicosatrienoic acid + H2O	Homo sapiens	elimination of the biological effects of the substrate, involved in regulation of renal eicosanoid levels and blood pressure, mechanism	dihydroxyeicosatrienoic acid	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
artery	renal, in the smooth muscle layer of the arterial wall	Homo sapiens	-
kidney	diseased and healthy, primarily vascular localization, low enzyme levels in the surrounding tubules	Homo sapiens	-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
0.00062	0.00852	diseased kidney, cell-free enzyme extract	Homo sapiens
0.00122	0.00549	healthy kidney, cell-free enzyme extract	Homo sapiens

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
epoxyeicosatrienoic acid + H2O	-	Homo sapiens	dihydroxyeicosatrienoic acid	-	?
epoxyeicosatrienoic acid + H2O	elimination of the biological effects of the substrate, involved in regulation of renal eicosanoid levels and blood pressure, mechanism	Homo sapiens	dihydroxyeicosatrienoic acid	-	?
trans-diphenylpropene oxide + H2O	-	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
SEH	-	Homo sapiens

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Release 2023.1 (January 2023)