Cloned (Comment) | Organism |
---|---|
expression pattern of sEH | Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-adamantyl-3-cyclohexylurea | a sEH-selective inhibitor | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0006 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.002 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.002 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.006 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
soluble | - |
Mus musculus | - |
- |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | Mus musculus C57BL/6 | - |
(8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P34914 | C57BL/6 mice | - |
Mus musculus C57BL/6 | P34914 | C57BL/6 mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
amygdala | - |
Mus musculus | - |
astrocyte | - |
Mus musculus | - |
brain | sEH distribution, immunohistochemical analysis, overview. sEH immunoreactivity is almost exclusively located in astrocytes throughout the brain, except in the central amygdala, where neurons are also positive for sEH | Mus musculus | - |
hippocampus | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,11Z,14Z)-8,9-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,11Z)-14,15-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (5Z,8Z,14Z)-11,12-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? | |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid + H2O | - |
Mus musculus C57BL/6 | (8Z,11Z,14Z)-5,6-dihydroxyeicosatrienoic acid | - |
? |
Synonyms | Comment | Organism |
---|---|---|
SEH | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | epoxide hydrolases comprise a family of enzymes important in detoxification and conversion of lipid signaling molecules, namely epoxyeicosatrienoic acids. Soluble epoxide hydrolase mediates the bulk of the cerebral epoxyeicosatrienoic acid metabolism, overview | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.005 | - |
(5Z,8Z,14Z)-11,12-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.005 | - |
(5Z,8Z,11Z)-14,15-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.05 | - |
(5Z,11Z,14Z)-8,9-epoxyeicosatrienoic acid | - |
Mus musculus | |
0.5 | - |
(8Z,11Z,14Z)-5,6-epoxyeicosatrienoic acid | - |
Mus musculus |