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Literature summary for 3.3.2.10 extracted from

  • Jones, P.D.; Wolf, N.M.; Morisseau, C.; Whetstone, P.; Hock, B.; Hammock, B.D.
    Fluorescent substrates for soluble epoxide hydrolase and application to inhibition studies (2005), Anal. Biochem., 343, 66-75.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.3.2.10

Application

Application Comment Organism
pharmacology the enzyme is a target for inhibition in therapy of disorders resulting from hypertension and vascular inflammation Mus musculus
pharmacology the enzyme is a target for inhibition in therapy of disorders resulting from hypertension and vascular inflammation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
1-cyclohexyl-3-dodecylurea i.e. 1-cyclohexyl-3-dodecyl-urea Homo sapiens
1-cyclohexyl-3-dodecylurea i.e. 1-cyclohexyl-3-dodecyl-urea Mus musculus
1-cyclohexyl-3-ethylurea i.e. N-cyclohexyl-N'-ethylurea Homo sapiens
1-cyclohexyl-3-ethylurea i.e. N-cyclohexyl-N'-ethylurea Mus musculus
1-cyclohexyl-3-hexylurea i.e. N-cyclohexyl-N'-hexylurea Homo sapiens
1-cyclohexyl-3-hexylurea i.e. N-cyclohexyl-N'-hexylurea Mus musculus
AUDA i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid Homo sapiens
AUDA i.e. 12-(3-adamantan-1-yl-ureido) dodecanoic acid Mus musculus
additional information IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates Homo sapiens
additional information IC50 values with different substrates and structure-activity relationships of enzyme inhibitors, development of an in vitro inhibition assay using fluorogenic substrates Mus musculus
N,N-dicyclohexylurea i.e. N,N-dicyclohexylurea Homo sapiens
N,N-dicyclohexylurea i.e. N,N-dicyclohexylurea Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
soluble
-
 Mus musculus
-
-
soluble
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate Mus musculus
0.12
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate Homo sapiens
0.13
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate Mus musculus
0.21
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate Mus musculus
0.26
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate Mus musculus
0.28
-
 purified recombinant enzyme, substrate cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate Mus musculus
0.36
-
 purified recombinant enzyme, substrate [3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate Homo sapiens
0.38
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate Homo sapiens
0.41
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate Homo sapiens
0.53
-
 purified recombinant enzyme, substrate cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate Homo sapiens
0.71
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate Homo sapiens
0.78
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate Mus musculus
0.86
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate Mus musculus
1.02
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate Homo sapiens
1.04
-
 purified recombinant enzyme, substrate [3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate Mus musculus
2.69
-
 purified recombinant enzyme, substrate cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
-
 Mus musculus ?
-
 ?
4-nitrophenyl-trans-2,3-epoxy-3-phenylpropyl carbonate + H2O
-
 Homo sapiens ?
-
 ?
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(2-methoxy-naphthalen-6-yl)methyl trans-2-(3-propyloxiran-2-yl) acetate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3,3-dimethyloxiran-2-yl)methyl carbonate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-ethyloxiran-2-yl)methyl carbonate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)acetate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-phenyloxiran-2-yl)methyl carbonate + H2O preferred fluorogenic substrate Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl (3-propyloxiran-2-yl)methyl carbonate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
cyano(6-methoxy-2-naphthyl)methyl [3-(4-nitrophenyl)oxiran-2-yl]methyl carbonate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
additional information reaction mechanism with flurogenic substrates Mus musculus ?
-
 ?
additional information reaction mechanism with flurogenic substrates Homo sapiens ?
-
 ?
trans-diphenylpropene oxide + H2O
-
 Mus musculus ?
-
 ?
trans-diphenylpropene oxide + H2O
-
 Homo sapiens ?
-
 ?
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O
-
 Mus musculus 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?
[3-(4-chlorophenyl)oxiran-2-yl]methyl cyano(6-methoxy-2-naphthyl)methyl carbonate + H2O
-
 Homo sapiens 6-methoxy-2-naphthaldehyde + CN- + ?
-
 ?

Synonyms

Synonyms Comment Organism
SEH
-
 Mus musculus
SEH
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
 assay at Mus musculus
30
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Mus musculus
7
-
 assay at Homo sapiens