Literature summary for 3.3.2.10 extracted from

Simpkins, A.N.; Rudic, R.D.; Roy, S.; Tsai, H.J.; Hammock, B.D.; Imig, J.D.
Soluble epoxide hydrolase inhibition modulates vascular remodeling (2010), Am. J. Physiol. Heart Circ. Physiol., 298, H795-H806.

Search for more literature for 3.3.2.10

Application

Application	Comment	Organism
pharmacology	SEH inhibition might have a potential for flow-induced vascular remodeling and neointimal formation	Rattus norvegicus

Protein Variants

Protein Variants	Comment	Organism
additional information	Ephx2 deletion antagonizes neointimal formation in vivo in an endothelium-dependent manner	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	SEH inhibition antagonizes neointimal formation in vivo in an endothelium-dependent manner	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
soluble	-	Rattus norvegicus	-	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Rattus norvegicus	SEH converts cardiovascular protective epoxyeicosatrienoic acids into less active diols attenuating the protective properties, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P80299	male Wistar-Kyoto rats	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	SEH converts cardiovascular protective epoxyeicosatrienoic acids into less active diols attenuating the protective properties, overview	Rattus norvegicus	?	-	?

Synonyms

Synonyms	Comment	Organism
SEH	-	Rattus norvegicus

General Information

General Information	Comment	Organism
malfunction	the enzyme and vascular remodeling are associated with cardiovascular disease. Inhibition of SEH prevents smooth muscle cell proliferation in vitro and affects vascular remodeling in vivo, but induces cell proliferation in the left carotid of spontaneously hypertensive stroke-prone rats	Rattus norvegicus

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Release 2023.1 (January 2023)