Inhibitors | Comment | Organism | Structure |
---|---|---|---|
7,8-styrene oxide | - |
Homo sapiens | |
trichloropropene oxide | - |
Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.055 | - |
cis-2-methylstyrene oxide | cytosolic enzyme | Homo sapiens | |
0.083 | - |
cis-1,2-dimethylstyrene oxide | microsomal enzyme | Homo sapiens | |
0.089 | - |
cis-1,2-dimethylstyrene oxide | cytosolic enzyme | Homo sapiens | |
0.143 | - |
7,8-styrene oxide | microsomal enzyme | Homo sapiens | |
0.229 | - |
2,2-dimethylstyrene oxide | microsomal enzyme | Homo sapiens | |
0.319 | - |
cis-2-methylstyrene oxide | microsomal enzyme | Homo sapiens | |
0.358 | - |
2,2-dimethylstyrene oxide | cytosolic enzyme | Homo sapiens | |
0.473 | - |
trans-1,2-dimethylstyrene oxide | microsomal enzyme | Homo sapiens | |
0.517 | - |
7,8-styrene oxide | cytosolic enzyme | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cytosol | - |
Homo sapiens | 5829 | - |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
0.145 | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2,2-dimethylstyrene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
cis-1,2-dimethylstyrene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
cis-2-methylstyrene oxide + H2O | - |
Homo sapiens | ? | - |
? | |
additional information | microsomal enzyme shows highest activity with trans-2-methylstyrane oxide, followed by styrene 7,8-oxide, cis-2-methylstyrene oxide, cis-1,2-dimethylstyrene oxide, trans-1,2-dimethylstyrene oxide and 2,2-dimethylstyrene oxide. With the cytosolic enzyme the same order is obtained for the first three substrates, whereas activity with 2,2-dimethylstyrene oxide is higher than with cis-1,2-dimethylstyrene oxide and no hydration occurs with trans-1,2-dimethylstyrene oxide | Homo sapiens | ? | - |
? | |
styrene 7,8-oxide + H2O | - |
Homo sapiens | styrene glycol | - |
? | |
trans-1,2-dimethylstyrene oxide + H2O | hydration by microsomal enzyme, no activity with cytosolic enzyme | Homo sapiens | ? | - |
? | |
trans-2-methylstyrene oxide + H2O | - |
Homo sapiens | ? | - |
? |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
7.4 | 9 | cytosolic enzyme shows higher activity at pH 7.4, microsomal enzyme shows higher activity at pH 9.0 | Homo sapiens |