Literature summary for 3.3.2.10 extracted from

Shi, D.H.; Xu, C.; Guo, B.X.; Wang, X.T.; Chen, Y.X.; Tan, R.X.
Inhibition of soluble epoxide hydrolase by extracts derived from inflammation-treating Chinese medicinal herbs (2008), Phytother. Res., 22, 1264-1268.

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Cloned(Commentary)

Cloned (Comment)	Organism
expressed with a baculovirus expression system in Spodoptera exigua larvae	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
12-(3-adamantane-1-yl-ureido)dodecanoic acid	shows an IC50 of 0.00013 mg/ml	Homo sapiens
additional information	the herb extract prepared from Sophora flavescens root afford the strongest inhibition of sEH with an IC50 of 0.00207 mg/ml, this is followed by other three extracts derived from the rhizome of Glycyrrhiza uralensis (IC50 0.0071 mg/ml), the root of Bupleurum chinense (IC50 0.00956 mg/ml), and the whole weed of Swertia pseudochinensis (IC50 0.01131 mg/ml)	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
62000	-	SDS-PAGE	Homo sapiens
62600	-	calculated from amino acid sequence	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(3-phenyl-oxiranyl)-acetic acid cyano-(6-methoxynaphthalen-2-yl)-methyl ester + H2O	-	Homo sapiens	6-methoxy-2-naphthaldehyde + ?	-	?

Synonyms

Synonyms	Comment	Organism
SEH	the enzyme plays an important role in the regulation of blood pressure and inflammation	Homo sapiens

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Release 2023.1 (January 2023)