Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 3.3.2.10 extracted from

  • Dietze, E.C.; Stephens, J.; Magdalou, J.; Bender, D.M.; Moyer, M.; Fowler, B.; Hammock, B.D.
    Inhibition of human and murine cytosolic epoxide hydrolase by group-selective reagents (1993), Comp. Biochem. Physiol. B, 104, 299-308.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
2,2'-Dithiopyridine 73% inhibition at 1 mM at pH 7.4 Homo sapiens
2,2'-Dithiopyridine 66% inhibition at 1 mM at pH 7.4 Mus musculus
2-Bromo-4'-nitroacetophenone complete inhibition at 1 mM at pH 7.4 Homo sapiens
2-Bromo-4'-nitroacetophenone 81% inhibition at 1 mM at pH 7.4 Mus musculus
4-nitrobenzenesulfonyl fluoride 94% inhibition at 1 mM at pH 7.4 Homo sapiens
4-nitrobenzenesulfonyl fluoride 47% inhibition at 1 mM at pH 7.4 Mus musculus
acetaldehyde/borohydride 13% inhibition at 1 mM at pH 7.4 Mus musculus
benzaldehyde/borohydride 16% inhibition at 1 mM at pH 7.4 Mus musculus
benzyl phenylmetanethiosulfonate complete inhibition at 1 mM at pH 7.4 Homo sapiens
benzyl phenylmethanethiosulfonate 94% inhibition at 1 mM at pH 7.4 Mus musculus
carbodiimide/glycine methyl ester 48% inhibition at 1 mM at pH 5.2, no inhibition at pH 7.4 Homo sapiens
carbodiimide/glycine methyl ester 65% inhibition at 1 mM at pH 5.2, 17% at pH 7.4 Mus musculus
diethyldicarbonate 72% inhibition at 1 mM at pH 7.4 Homo sapiens
diethyldicarbonate 80% inhibition at 1 mM at pH 7.4 Mus musculus
diisopropyl fluorophosphate 16% inhibition at 1 mM at pH 7.4 Mus musculus
DTNB 86% inhibition at 1 mM at pH 7.4 Homo sapiens
DTNB 59% inhibition at 1 mM at pH 7.4 Mus musculus
methyl methanethiosulfonate 89% inhibition at 1 mM at pH 7.4 Homo sapiens
methyl methanethiosulfonate 89% inhibition at 1 mM at pH 7.4 Mus musculus
additional information N-acetyl imidazole, N-bromosuccimide, cyclohexandione, acetaldehyde/borohydride and benzaldehyde/borohydride are poor inhibitors, no inhibition by PMSF and diisopropyl fluorophosphate, no inhibition by amino-, guanido-, or activated serine-selective reagents Homo sapiens
additional information cyclohexandione is a poor inhibitor, no inhibition by amino-, guanido-, or activated serine-selective reagents Mus musculus
N-acetyl imidazole 12% inhibition at 1 mM at pH 7.4 Mus musculus
N-bromosuccimide 98% inhibition at 1 mM at pH 7.4 Mus musculus
N-ethylmaleimide 98% inhibition at 1 mM at pH 7.4 Homo sapiens
N-ethylmaleimide 21% inhibition at 1 mM at pH 7.4 Mus musculus
N-Phenylmaleimide 97% inhibition at 1 mM at pH 7.4 Homo sapiens
N-Phenylmaleimide 60% inhibition at 1 mM at pH 7.4 Mus musculus
ninhydrin 13% inhibition at 1 mM at pH 7.4 Homo sapiens
ninhydrin 12% inhibition at 1 mM at pH 7.4 Mus musculus
Phenylglyoxal 19% inhibition at 1 mM at pH 7.4 Homo sapiens
Phenylglyoxal 22% inhibition at 1 mM at pH 7.4 Mus musculus
phenylthioisocyanate 54% inhibition at 1 mM at pH 7.4 Homo sapiens
phenylthioisocyanate 34% inhibition at 1 mM at pH 7.4 Mus musculus
PMSF 27% inhibition at 1 mM at pH 7.4 Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
Mus musculus 5829
-
cytosol
-
Homo sapiens 5829
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
Swiss Webster mice
-

Purification (Commentary)

Purification (Comment) Organism
from liver by affinity chromatography Mus musculus
from liver by affinity chromatography Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Mus musculus
-
liver
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
CEH
-
Mus musculus
CEH
-
Homo sapiens
Cytosolic epoxide hydrolase
-
Mus musculus
Cytosolic epoxide hydrolase
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.2 8.3 assay at pH 5.2, 7.4, and 8.3 Mus musculus
5.2 8.3 assay at pH 5.2, 7.4, and 8.3 Homo sapiens