Information on EC 2.5.1.18 - glutathione transferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY
2.5.1.18
-
RECOMMENDED NAME
GeneOntology No.
glutathione transferase
-
REACTION
REACTION DIAGRAM
COMMENTARY
ORGANISM
UNIPROT
LITERATURE
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
random steady state mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
kinetic mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
kinetic mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
mechanisms for formation of specific mono(glutathionyl) or bis(glutathionyl) conjugates
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
the enzyme uses a rapid-equilibrium random-order ternary-complex mechanism or a compulsory order ternary-complex mechanism
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
active site involving residue Trp234, and substrate binding structure, isozyme GST T1-1
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
the enzyme uses a rapid equilibrium random sequential bi-bi mechanism with intrasubunit modulation between GSH binding site, the G-site, and electrophile binding site, the H-site, Trp12, Phe35 and Ile118 are involved in substrate binding, Phe35 is important for catalytic activity
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
substrate binding: Tyr9 is responsible for the deprotonation of GSH and Lys15, but also Gln71 are involved, active site and substrate binding structure, overview
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
active site structure: Tyr111 indirectly stabilizes glutathione binding, Tyr119 modulates hydrophobic substrate binding, and Phe123 indirectly modulates catalysis. An aromatic zipper in the H-site contributing a network of aromatic pi-pi interactions. Several residues of the cluster directly interact with the hydrophobic substrate while others indirectly maintain conformational stability of the dimeric structure through the C-terminal domain II
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
catalytic mechanism of kappa class GST, overview. Substrate binding induces a conformational change of the active site from an open conformation in the apo-form to a closed conformation in the S-hexylglutathione-bound complex, facilitating formations of the G site (GSH-binding site) and the H site (hydrophobic substrate-binding site). The conserved Ser16 at the G site functions as the catalytic residue in the deprotonation of the thiol group and the conserved Asp69, Ser200,Asp201 andArg202 form a network of interactions with gamma -glutamyl carboxylate to stabilize the thiolate anion. The H site is a large hydrophobic pocket with conformational flexibility to allow the binding of different hydrophobic substrates. The kinetic mechanism of hGSTk conforms to a rapid equilibrium random sequential Bi Bi model
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
catalytic mechanism, ovverview
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview; active site structure and catalytic mechanism, overview
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
the mutant C169A exhibits cooperative behaviour and a ping pong mechanism whereby liberation of a proton from a reduced enzyme-glutathione complex to form an enzyme-unprotonated glutathione complex is essentially irreversible
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
substrate binding structure and reaction mechanism, conformational changes, detailed overview
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
substrate specificity and catalytic mechanism, overview
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
catalytic mechanism of isozyme GSTH1-1
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
catalytic mechanism of isozyme GSTH1-1
Agrobacterium tumefaciens C58
-
-
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
-
-
-
-
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
aryl group transfer
-
-
-
-
aryl group transfer
-
-
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-hydroxy-2-nonenal detoxification
-
-
gliotoxin biosynthesis
-
-
glutathione-mediated detoxification I
-
-
glutathione-mediated detoxification II
-
-
glutathione metabolism
-
-
Glutathione metabolism
-
-
Metabolism of xenobiotics by cytochrome P450
-
-
Drug metabolism - cytochrome P450
-
-
SYSTEMATIC NAME
IUBMB Comments
RX:glutathione R-transferase
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
SYNONYMS
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
2-hydroxychromene-2-carboxylic acid isomerase
-
-
26GST
26.5 kDa isozyme
allergen Der p 2
-
-
allergen Der p 8
-
-
alpha class glutathione transferase
-
alpha class glutathione transferase
-
alpha class glutathione transferase
-
-
alpha class glutathione transferase
-
alpha GST
-
-
alpha GST
-
-
alpha-class glutathione transferase
-
alpha-class glutathione transferase
Sus scrofa Yorkshire pig
-
-
asGST5.5
-
-
AtuGSTH1-1
Agrobacterium tumefaciens C58
-
-
-
bmGSTD
-
-
cGST
Mus musculus CD1
-
-
-
Chi class GST
-
-
class mu glutathione S-transferase
-
-
delta class glutathione transferase
-
delta-class glutathione S-transferase
-
delta-class glutathione S-transferase
-
delta-class glutathione S-transferase
Sarcoptes scabiei ssGST3
-
-
Delta-class glutathione transferase
-
-
epsilon class GST
-
-
Epsilon glutathione S-transferase
-
Epsilon glutathione transferase
-
-
Epsilon GST
-
-
epsilon-class glutathione transferase
-
glutathione S-alkyl transferase
-
-
-
-
glutathione S-aralkyltransferase
-
-
-
-
glutathione S-aryltransferase
-
-
-
-
glutathione S-transferase
-
-
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
formerly
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
a rho-class glutathione S-transferase
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
Mus musculus CD1
-
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase
-
glutathione S-transferase
-
glutathione S-transferase
-
-
glutathione S-transferase
-
-
glutathione S-transferase A1-1
-
-
glutathione S-transferase A3-3
-
-
glutathione S-transferase AdFSTD3-3
-
-
glutathione S-transferase I
-
-
glutathione S-transferase P1-1
-
-
glutathione S-transferase P1-1
-
glutathione S-transferase pi
-
-
glutathione S-transferase X
-
-
-
-
glutathione S-transferases
-
-
glutathione S-transferases
-
-
glutathione S-transferases
-
glutathione S-transferases
-
-
glutathione transferase
-
-
glutathione transferase A1-1
-
-
glutathione transferase A1-1
-
glutathione transferase A1-1
Sus scrofa Yorkshire pig
-
-
glutathione transferase A4-4
-
-
glutathione transferase M1-1
-
-
glutathione transferase M2-2
-
-
glutathione transferase P1-1
-
-
glutathione transferase P1-1
-
glutathione transferase Pi
-
-
glutathione transferase T1-1
-
-
glutathione transferase zeta
-
-
glutathione transferase Zeta 1-1
-
variants glutathione transferase Zeta 1a-1a, glutathione transferase Zeta 1b-1b, glutathione transferase Zeta 1c-1c, glutathione transferase Zeta 1d-1d
glutathione transferase zeta1-1
-
glutathione transferase-like protein
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
isozymes alpha; isozymes mu; isozymes pi
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
-
glutathione-S-transferase
-
glutathione-S-transferase pi
-
-
glutathione-transferase
-
GmGSTU4-4
-
GSH S-transferase
-
-
-
-
GSH transferase
-
-
GSH transferase homologue
-
-
GSH-S transferase rho
-
-
GSHTase-P
-
-
-
-
GST
-
-
GST
Mus musculus BALB/c
-
-
-
GST A1-1
-
isozyme
GST A1-1
-
-
GST A1-1
isozyme
GST A1-1
-
GST A1-1
Sus scrofa Yorkshire pig
-
-
GST A2-2
-
isozyme
GST A2-2
isozyme
GST A2-2
isozyme
GST A3-3
isozyme
GST A3-3
isozyme
GST A4-4
isozyme
GST adgstD4-4
-
-
GST alpha
-
-
GST I
-
isozyme
GST I
-
-
GST II
-
isozyme
GST III
-
isozyme
GST IV
-
isozyme
GST M1-1
-
originally called GST mu
GST M1-1
isozyme
GST M2-2
-
-
GST M2-2
isozyme
GST M4-4
isozyme
GST M5-5
isozyme
GST mu
-
-
GST O1-1
isozyme
GST P1-1
isozyme
GST pi
-
-
GST pi
-
-
GST T1-1
isozyme
GST T1-1
-
-
GST T1-1
-
-
GST Z1-1
isozyme
GST-26
-
-
GST-OCX-32
fusion protein
GSTA1-1
isozyme
GSTA1-1
-
-
GSTA1-1
isozyme
GSTA2-2
isozyme
GSTA2-2
isozyme
GSTA3-3
isozyme
GSTA3-3
isozyme
GSTA4-4
-
-
GSTE1
-
-
GSTE2
-
-
GSTE3
-
-
GSTE4
-
-
GSTE5
-
-
GSTE6
-
-
GSTE7
-
-
GSTE8
-
-
GSTF3
-
phi class isozyme
GSTF5
-
phi class isozyme
GSTk
-
-
GSTM1-1
-
-
GSTP
-
-
GSTP-1
-
phi class GST
GSTS1
sigma class isozyme
GSTS2
sigma class isozyme
GSTS3
non-enzymatic GST
GSTT1
-
-
GSTT2B-2B
-
GSTU21
-
-
GSTU3
-
tau class isozyme
GSTU4
-
tau class isozyme
GSTU5
-
tau class isozyme
HCCA isomerase
-
-
hGSTA-3
-
-
hGSTA1-1
-
-
hGSTZ1-1
-
-
kappa class glutathione transferase
-
-
kappa class glutathione transferase
-
-
kappa class GSH transferase
-
-
Kappa class GST
-
-
microsomal glutathione transferase 1
-
-
mtMGST1
Rattus norvegicus Sprague-Dawley
-
-
-
mu class glutathione S-transferase
-
mu glutathione transferase
-
-
nu-class glutathione transferase
-
-
Omega class GST
-
Omega class GST
-
-
omega glutathione S-transferase
-
-
omega-class glutathione S-transferase
-
pGSTA1
Sus scrofa Yorkshire pig
-
-
phi class glutathione transferase
-
-
Pi class GST
-
PvGSTF1-1
-
-
PvGSTU2-2
-
-
PvGSTU3-3
-
-
S-(hydroxyalkyl)glutathione lyase
-
-
-
-
selenium-containing glutathione transferase zeta1-1
-
-
seleno-hGSTZ1-1
-
-
SGST26.5
-
isoform of 26500 Da
Sigma class GST
-
sigma glutathione S-transferase
-
sigma-class glutathione S-transferase
-
sigma-class GST
-
ssGST3
Sarcoptes scabiei ssGST3
-
-
ssGST5
Sarcoptes scabiei ssGST3
-
-
tau class glutathione transferase
-
tau class glutathione transferase
-
tau class glutathione transferase
-
-
tau class GST
-
tau class GSTU4-4
-
theta class glutathione S-transferase
-
theta class glutathione transferase T1-1
-
-
theta class GST
-
theta class GST
-
-
theta class GST
-
theta class GST
-
-
theta-class glutathione transferase
-
-
thiol-dependent reductase I
-
-
Ure2p mutant A122C
-
-
YghU
-
gene name
zeta class glutathione S-transferase
-
-
Zeta class GST
-
microsomal glutathione transferase-1
membrane-bound enzyme with both glutathione transferase and hydroperoxidase activities
additional information
two major GST subunits are mu-class GSTs, one minor GST subunit is a putative theta-class GST
additional information
-
the enzyme belongs to the glutathione-S-transferase family of multifunctional enzymes
additional information
the Necator americanus GST isozymes belong to a nematode-specific nu-class GST family
additional information
the enzyme belongs to the family of glutathione S-transferases
additional information
cf. EC 1.11.1.9
additional information
-
MGST1 that belongs to the membrane associated proteins in eicosanoid and glutathione metabolism, MAPEG, superfamily
additional information
-
overview of nomenclature of rat glutathione transferase isoenzymes
CAS REGISTRY NUMBER
COMMENTARY
50812-37-8
-
ORGANISM
COMMENTARY
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
alpha, mu and pi class isozymes
-
-
Manually annotated by BRENDA team
PMD and PMD-R strains, the latter is a highly resistant strain, Isla Mujeres (IM) strain, New Orleans (NO) susceptible strain, isozymes GSTE1-GSTE8
-
-
Manually annotated by BRENDA team
gene Atu3701 encoding an eta class GST, i.e. AtuGSTH1-1
-
-
Manually annotated by BRENDA team
Agrobacterium tumefaciens C58
gene Atu3701 encoding an eta class GST, i.e. AtuGSTH1-1
-
-
Manually annotated by BRENDA team
GST-1; canine hookworm, gene gst-1
SwissProt
Manually annotated by BRENDA team
enzyme form AdGSTD4-4
-
-
Manually annotated by BRENDA team
GST adgstD4-4
-
-
Manually annotated by BRENDA team
isozyme adGSTD4-4
UniProt
Manually annotated by BRENDA team
epsilon class isozyme agGSTe2
Uniprot
Manually annotated by BRENDA team
different subspecies e.g. ligustica, anatolia, and caucasia
-
-
Manually annotated by BRENDA team
isoenzyme I; isoenzyme II
-
-
Manually annotated by BRENDA team
54 GST genes of the Arabidopsis thaliana GST superfamily
UniProt
Manually annotated by BRENDA team
ecotype Columbia, isozyme GSTU19, a tau class GST
UniProt
Manually annotated by BRENDA team
ecotype Wassijlieska, phi class isozyme, encoded by inducible gene GSTU26; ecotype Wassijlieska, tau class isozyme, encoded by constitutive gene GSTF9
-
-
Manually annotated by BRENDA team
genes and isozymes GSTU19 and GSTF2
-
-
Manually annotated by BRENDA team
isozyme Phi, i.e. GSTF, isozyme Tau, i.e. GSTU, isozyme Theta, i.e. GSTT, isozyme Zeta, i.e. GSTZ, and isozyme Lambda, i.e. GSTL, alll encoded by several genes, overview
-
-
Manually annotated by BRENDA team
strain SUD-S and GER-01
-
-
Manually annotated by BRENDA team
Bemisia tabaci SUD-S
strain SUD-S and GER-01
-
-
Manually annotated by BRENDA team
delta-GST
SwissProt
Manually annotated by BRENDA team
omega-GST
UniProt
Manually annotated by BRENDA team
sigma-GST
SwissProt
Manually annotated by BRENDA team
liver: 2 major forms: I and II
-
-
Manually annotated by BRENDA team
retina: 2 isoenzymes
-
-
Manually annotated by BRENDA team
isozymes GST2 and GST3
-
-
Manually annotated by BRENDA team
strain LB400, gene bphK
-
-
Manually annotated by BRENDA team
beagle dogs
-
-
Manually annotated by BRENDA team
a cold-adapted marine bivalve Iceandic scallop, mu-class enzyme
SwissProt
Manually annotated by BRENDA team
pumpkin
-
-
Manually annotated by BRENDA team
isozyme CgGSTM1; gene CgGSTM1
UniProt
Manually annotated by BRENDA team
isozyme CgGSTM2; gene CgGSTM2
UniProt
Manually annotated by BRENDA team
Straus 1820
-
-
Manually annotated by BRENDA team
delta class GST; housedust mite, delta class GST isozyme
SwissProt
Manually annotated by BRENDA team
dust mite, isozymes Der p 8 and Der p 2
-
-
Manually annotated by BRENDA team
mu class GST; housedust mite, mu class GST isozyme
SwissProt
Manually annotated by BRENDA team
isozymes GSTD1 and GSTD10
-
-
Manually annotated by BRENDA team
Enterobacter cloacae CIP 6085
CIP 6085
-
-
Manually annotated by BRENDA team
ATCC 25922 and ATCC 25422
-
-
Manually annotated by BRENDA team
gene yghU
-
-
Manually annotated by BRENDA team
strain TG2
Uniprot
Manually annotated by BRENDA team
Escherichia coli TG2
strain TG2
Uniprot
Manually annotated by BRENDA team
from an indian isolate of buffalo liver origin
-
-
Manually annotated by BRENDA team
GSH-S transferase rho
-
-
Manually annotated by BRENDA team
isozyme GSTU4-4
UniProt
Manually annotated by BRENDA team
isozyme GSTS1; disk abalone, subspecies Haliotis discus discus
UniProt
Manually annotated by BRENDA team
isozyme GSTS2; disk abalone, subspecies Haliotis discus discus
UniProt
Manually annotated by BRENDA team
isozyme GSTS3; disk abalone, subspecies Haliotis discus discus
UniProt
Manually annotated by BRENDA team
two omega GST genes, HdGSTO1 and HdGSTO2
-
-
Manually annotated by BRENDA team
human hookworm, isozyme GST Nu2-2
-
-
Manually annotated by BRENDA team
rubber tree, 5 forms
-
-
Manually annotated by BRENDA team
13 forms
-
-
Manually annotated by BRENDA team
alpha class GST A1-1
-
-
Manually annotated by BRENDA team
basic and acid isoenzyme
-
-
Manually annotated by BRENDA team
enzyme form glutathione S-transferase P1-1, recombinant
-
-
Manually annotated by BRENDA team
GST isozymes A1-1, A2-2, M1-1, M2-2, and P1-1
-
-
Manually annotated by BRENDA team
isozyme GST P1-1
-
-
Manually annotated by BRENDA team
isozyme GST T1-1
-
-
Manually annotated by BRENDA team
isozyme GST T1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTA1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTA1-1
-
-
Manually annotated by BRENDA team
isozyme GSTA2-2
UniProt
Manually annotated by BRENDA team
isozyme GSTA3-3
UniProt
Manually annotated by BRENDA team
isozyme GSTA4-4
-
-
Manually annotated by BRENDA team
isozyme GSTA4-4
UniProt
Manually annotated by BRENDA team
isozyme GSTA5-5
UniProt
Manually annotated by BRENDA team
isozyme GSTM1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTM2-2
UniProt
Manually annotated by BRENDA team
isozyme GSTM3-3
UniProt
Manually annotated by BRENDA team
isozyme GSTM4-4
UniProt
Manually annotated by BRENDA team
isozyme GSTM5-5
UniProt
Manually annotated by BRENDA team
isozyme GSTO1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTO2-2
SwissProt
Manually annotated by BRENDA team
isozyme GSTO2; omega class isozymes GSTO1-1 and GSTO2
SwissProt
Manually annotated by BRENDA team
isozyme GSTP1
-
-
Manually annotated by BRENDA team
isozyme GSTP1-1
-
-
Manually annotated by BRENDA team
isozyme GSTP1-1, encoded by a single functional GSTP gene termed GSTP1 that maps to chromosome 11q13; isozyme GSTT1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTS1-1
UniProt
Manually annotated by BRENDA team
isozyme GSTT2-2
UniProt
Manually annotated by BRENDA team
isozyme GSTZ1-1
SwissProt
Manually annotated by BRENDA team
isozyme hGSTA1-1
-
-
Manually annotated by BRENDA team
isozymes GST A1-1 and GST A4-4
-
-
Manually annotated by BRENDA team
isozymes GSTA1-1, GSTM1-1, and GSTP1-1
-
-
Manually annotated by BRENDA team
isozymes GSTA1-1, GSTM2-2, and GSTP1-1
-
-
Manually annotated by BRENDA team
male
-
-
Manually annotated by BRENDA team
multiple forms
-
-
Manually annotated by BRENDA team
polycythaemia patients
-
-
Manually annotated by BRENDA team
theta class isozyme GST T1-1
UniProt
Manually annotated by BRENDA team
transferase P1-1
-
-
Manually annotated by BRENDA team
barley
-
-
Manually annotated by BRENDA team
isozyme SIGST; tau class isozyme SIGST
SwissProt
Manually annotated by BRENDA team
sigma class isozyme, gene gst; fall webworm, gene gst, sigma class isozyme
SwissProt
Manually annotated by BRENDA team
Ilex sp.
squid
-
-
Manually annotated by BRENDA team
AF101 and CIP 666
-
-
Manually annotated by BRENDA team
Antarctic soft-shelled clam
-
-
Manually annotated by BRENDA team
three field populations collected from Nanyang city of Henan Province, and Wuzhou and Hezhou cities of Guangxi Province, China
-
-
Manually annotated by BRENDA team
a marine shrimp, a mu class isozyme
-
-
Manually annotated by BRENDA team
isozyme GSTD1 or Delta or Theta class isozyme; Sigma and Delta GST isozymes
UniProt
Manually annotated by BRENDA team
sheep blowfly
-
-
Manually annotated by BRENDA team
crab-eating monkey
-
-
Manually annotated by BRENDA team
cynomolgus monkey
-
-
Manually annotated by BRENDA team
japanese monkey
-
-
Manually annotated by BRENDA team
rhesus monkey
-
-
Manually annotated by BRENDA team
cabbage moth
-
-
Manually annotated by BRENDA team
cytosolic enzymes, referred to as alpha, mu, pi and theta, and microsomal enzyme
-
-
Manually annotated by BRENDA team
alfalfa
-
-
Manually annotated by BRENDA team
striped bass
-
-
Manually annotated by BRENDA team
3 forms, products of different genes: MI, MII, MIII
-
-
Manually annotated by BRENDA team
a catalytically active monoclonal antibody fragment
-
-
Manually annotated by BRENDA team
Balb/c mice
-
-
Manually annotated by BRENDA team
CD1 mice
-
-
Manually annotated by BRENDA team
isoenzyme alpha; isoenzyme mu; isoenzyme pi
-
-
Manually annotated by BRENDA team
isozyme GST T1-1
-
-
Manually annotated by BRENDA team
multiple forms
-
-
Manually annotated by BRENDA team
wild-type and pi null mutant
-
-
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
-
-
Manually annotated by BRENDA team
Mus musculus CD1
CD1 mice
-
-
Manually annotated by BRENDA team
two epsilon-class GSTs MdGST6A and MdGST6B
UniProt
Manually annotated by BRENDA team
Myathropa florea
-
-
-
Manually annotated by BRENDA team
genes Na-gst-1, Na-gst-2, and Na-gst-3 encoding isozymes GST-1, GST-2, and GST-3
UniProt
Manually annotated by BRENDA team
coho salmon, several isozymes, e.g. pi and rho-class GSTs, as well as alpha and mu class isozymes
SwissProt
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
isozymes of pi, phi, mu, and alpha class
-
-
Manually annotated by BRENDA team
GSTU17; isozyme GSTU17
UniProt
Manually annotated by BRENDA team
rice, v. Tequing, indica
-
-
Manually annotated by BRENDA team
ssp. indica var. IR64, at least 79 genes encoding GSTs
-
-
Manually annotated by BRENDA team
sheep, 7 cationic isoenzymes, 5 anionic isoenzymes
-
-
Manually annotated by BRENDA team
enzyme form GSTR1
SwissProt
Manually annotated by BRENDA team
isozymes of classes mu, pi, theta, alpha, and tau
-
-
Manually annotated by BRENDA team
runner bean
-
-
Manually annotated by BRENDA team
french bean
-
-
Manually annotated by BRENDA team
isozymes PvGSTF1-1, PvGSTU2-2 and PvGSTU3-3
-
-
Manually annotated by BRENDA team
theta class isozyme, GSTT1, gene gstt1
SwissProt
Manually annotated by BRENDA team
gene gst
Uniprot
Manually annotated by BRENDA team
subsp. nigeriensis, a rodent malarial parasite, propagated in Swiss albino mice
-
-
Manually annotated by BRENDA team
Proteus mirabilis AF 2924
AF 2924
-
-
Manually annotated by BRENDA team
ATCC8427
-
-
Manually annotated by BRENDA team
Proteus vulgaris ATCC8427
ATCC8427
-
-
Manually annotated by BRENDA team
3 isoenzymes: 1, 2.1, 2.2
-
-
Manually annotated by BRENDA team
alpha class isozymes GSTA2-2, GSTA1-2 and GSTA1-1
-
-
Manually annotated by BRENDA team
at least 7 forms
-
-
Manually annotated by BRENDA team
Fischer-344 rats
-
-
Manually annotated by BRENDA team
isozymes GSTA1-1, GSTM1-1, and GSTP1-1
-
-
Manually annotated by BRENDA team
male specific-pathogen-free Sprague Dawley
-
-
Manually annotated by BRENDA team
male sprague-dawley rats
-
-
Manually annotated by BRENDA team
mu class isozyme M1-1, GST-M1-1
-
-
Manually annotated by BRENDA team
recombinant
-
-
Manually annotated by BRENDA team
theta class isozyme GST T2-2
-
-
Manually annotated by BRENDA team
various isoenzymes
-
-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
-
-
Manually annotated by BRENDA team
the single-site mutation A122C and N124A/V (but not N124S/Y/C) restores the GST activity of Ure2p protein toward 1-chloro-2,4-dinitrobenzene, while causing a substantial reduction in glutathione peroxidase activity
-
-
Manually annotated by BRENDA team
delta GST isozyme; type hominis, delta GST isozyme
SwissProt
Manually annotated by BRENDA team
delta GST isozyme; var. vulpes delta, the astigmatid mite, delta GST isozyme; mu GST isozyme; type hominis, mu GST isozyme
SwissProt
Manually annotated by BRENDA team
mu GST isozyme; type hominis, mu GST isozyme
SwissProt
Manually annotated by BRENDA team
ssGST3
SwissProt
Manually annotated by BRENDA team
type hominis
SwissProt
Manually annotated by BRENDA team
Sarcoptes scabiei ssGST3
ssGST3
SwissProt
Manually annotated by BRENDA team
gene from GST descended from Schistosoma containing in vector pET42a(+)
-
-
Manually annotated by BRENDA team
Serratia marcescens CIP 6755
CIP 6755
-
-
Manually annotated by BRENDA team
giant foxtail, grass weed
-
-
Manually annotated by BRENDA team
six glutathione S-transferase-like genes, sogst1-sogst6
-
-
Manually annotated by BRENDA team
common cutworm
-
-
Manually annotated by BRENDA team
5 major and 3 minor forms
-
-
Manually annotated by BRENDA team
gene GSTA1
UniProt
Manually annotated by BRENDA team
Sus scrofa Yorkshire pig
gene GSTA1
UniProt
Manually annotated by BRENDA team
strain PCC 6301
-
-
Manually annotated by BRENDA team
fragment
UniProt
Manually annotated by BRENDA team
white clover
-
-
Manually annotated by BRENDA team
cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
cv. Palesio
-
-
Manually annotated by BRENDA team
GST 19E50; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GST 28e45; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GST Cla47; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GST1; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTA1; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTA2; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF1; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF2; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF3; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF4; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF5; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTF6; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTU1A; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTU1B; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTU1C; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTU2; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTU3; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
GSTZ1; cv. MV Emese, drought-tolerant cv. Plainsman, and drought-sensitive cv. GKE
UniProt
Manually annotated by BRENDA team
cultivar Gamay Freaux variant Teinturier
UniProt
Manually annotated by BRENDA team
porina moth
-
-
Manually annotated by BRENDA team
2 forms: GST I, GST II
-
-
Manually annotated by BRENDA team
cv. Belgrano
-
-
Manually annotated by BRENDA team
isozyme GST I
-
-
Manually annotated by BRENDA team
isozyme GST I
Uniprot
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY
LITERATURE
evolution
-
the enzyme belongs to the glutathione transferase, GST, superfamily. Phylogenetic analysis shows, among the Delta class, GSTD1 and GSTD10 appear to be recently diverged transcripts with 86% amino acid sequence similarity
evolution
-
kappa class GSTs are a distinct class of the GST superfamily or Trx (thioredoxin)-fold superfamily because of their unique cellular localization, function and structure. GSTks do not contain a conserved CXXC motif at the active site
evolution
-
structures and properties of YghU and YfcG indicate that they are members of the same distinct subfamily of GSH transferase homologues, proposed to be called the Nu-class GSH transferases. Cytoscape cluster analysis of the GSH transferase superfamily, overvew
evolution
the cytosolic glutathione transferases, GSTs, comprise a super family of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a super family of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a super family of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions; the cytosolic glutathione transferases, GSTs, comprise a superfamily of proteins that can be categorized into multiple classes with a mixture of highly specific and overlapping functions
evolution
GST5118 belongs to a distinct class named GSTFuA, for fungal specific GST class A, as part of the GST superfamily
evolution
-
glutathione transferase classes alpha, pi, and mu and their GSH activation mechanism, overview
evolution
-
the enzyme belongs to the soluble plant GST superfamily of dimeric enzymes, isozymes classes, overview. Dehydroascorbate reductase and tetrachlorohydroquinone dehalogenase-like proteins also belong to the GST superfamily
evolution
-
TDR1 belongs to the glutathione-S-transferase (GST) superfamily
malfunction
-
partial silencing of either GSTe7 or GSTe2 by RNA interference results in an increased susceptibility to the pyrethroid, deltamethrin
malfunction
mutation at Phe108, located just below Arg113 in the binding pocket, reduces the affinity and catalytic activity to both GSH and the electrophilic co-substrate, 1-chloro-2,4-dinitrobenzene
malfunction
a single SNP causing an I71L substitution in African subjects causes diminished activity with several substrates including CDNB and 7-chloro-4-nitrobenz-2-oxa-1,3-diazole as a result of an elevation in its Km for GSH, but the specific activity towards DELTA5-androsten-3,17-dione and the Km GSH of the L71 variant are not changed; associations between GSTO1 polymorphisms and vascular dementia and stroke. A236V polymorphism: the V236 variant protein has low specific activity with a range of substrates and shows marked heat instability. It seems highly likely that this substitution leads to GSTO1-1 deficiency in homozygotes. E155 deletion causes a significant folding defectthat may explain the deficiency associated with this deletion. The V236 variant protein has low specific activity with a range of substrates and shows marked heat instability; differences in the catalytic activity of the V105 and I105 variants to carcinogenic diolepoxides may underlie the associations between these alleles and cancer susceptibility; GSTM1-1 deficiency contributes significantly to survival after chemotherapy for childhood leukemia; natural mutations D43N, T65M and T104P, and a frame shift mutation at G412 cause GSTT1-1 deficiency; the GSTT12B allele results from the relatively rare T104P substitution in Scandinavian individuals, and appears to destabilize the protein and result in GSTT1-1 deficiency. The relatively common deletion of the GSTT2b pseudogene is associated with an altered risk of esophageal squamous cell carcinoma; the GSTZ1-A protein has relatively high activity with (±)-2-bromo-3-(4-nitrophenyl)propanoic acid but it has low isomerase activity with its natural substrate maleylacetoacetate; two rare intronic variants (IVS2+11A>C and IVS3+13T>C) are reported, the intron-2 SNP is significantly transmitted to asthma-affected children
malfunction
-
isozymes AtGSTs F11, F12, F14 and U14, in which the catalytic serine is replaced by a non-proton abstracting residue, show abolished transferase activity
metabolism
-
glutathione S-transferase P1-1 is one of the most important members of phase II detoxification enzyme family which catalyzes the conjugation of glutathione with broad substrates such as chemotherapeutic agents
metabolism
the classical phase II detoxification glutathione transferases are key metabolic enzymes that catalyze the conjugation of glutathione to various electrophilic compounds
physiological function
-
glutathione transferases are a major detoxification system in helminths
physiological function
-
the glutathione-S-transferases are a family of multifunctional enzymes involved in the detoxification of electrophilic xenobiotics primarily through conjugation to reduced glutathione
physiological function
-
overlapping and specific roles of rice glutathione S-transferase genes during development and stress responses, role of GSTs in mediating crosstalk between various stress and hormone response pathways
physiological function
bmGSTO might be involved in the increase in level of insecticide resistance for lepidopteran insects
physiological function
-
HdGSTO1 might play important protective roles against environmental stress. Under thermal stress, HdGSTO2 expression is repressed in a time-dependent pattern, implying different physiological roles of the isozymes under stress
physiological function
the isozymes may be involved in the detoxification and/or transport of heme
physiological function
-
glutathione S-transferases are a family of detoxifying enzymes that catalyze the conjugation of glutathione to electrophiles, thereby increasing the solubility of xenobiotics and aiding its excretion from the cell
physiological function
through alternative splicing, two of these GSTTs form fusions with Myb transcription factor-like domains, discrete localization within the nucleus, possibly serving role in reducing nucleic acid hydroperoxides or in signalling
physiological function
GSTU1B and GSTF6 genes may play important roles in monocarpic senescence of wheat; GSTU1B and GSTF6 genes may play important roles in monocarpic senescence of wheat
physiological function
-
GSTs are important phase II drug-metabolizing enzymes that play a major role in protecting cells from the toxic insults of electrophilic compounds
physiological function
-
GSTE2 is implicated in conferring resistance to DDT for the dengue vector Aedes aegypti. Epsilon GSTs have DDT dehydrochlorinase activity, GSTe2 and two additional Epsilon GST genes, GSTe5 and GSTe7, are expressed at elevated levels in the resistant population and the recombinant homodimer GSTE5-5 also exhibits low levels of DDT dehydrochlorinase activity
physiological function
-
role of mtMGST1 in the oxidant peroxynitrite-induced mitochondrial permeability transition, MPT, pore opening, peroxynitrite induces the swelling of mitoplasts (inner membranes including the matrix) as well as of the mitochondria. mtMGST1, ADP (an adenine nucleotide translocator),and cyclosporin A function as a MPT pore in peroxynitrite-induced swelling, in which the Ca2+ released by peroxynitrite might play an important role in the complex formation
physiological function
-
GSTF2 and GSTF3 may have roles in regulating the binding and transport of defence-related compounds in planta
physiological function
-
glutathione transferases are a family of enzymes that primarily catalyse nucleophilic addition of the thiol of GSH to a variety of hydrophobic electrophiles in the cellular detoxification of cytotoxic and genotoxic compounds
physiological function
all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Because of its highly specialized activity the Sigma class GST is generally known as hemopoietic prostaglandin D synthase, HPGDS; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Because of its highly specialized role catalyzing the penultimate step in the catabolism of tyrosine, GSTZ1-1 is also known as maleylacetoacetate isomerase, MAAI; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. GSTA1-1 is likely to play a significant role in binding hydrophobic ligands such as bilirubin and steroid hormones; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. GSTA3-3 may play an important physiological role as it efficiently catalyzes the isomerization of DELTA5-3-ketosteroids in the synthesis of testosterone and progesterone; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. GSTO1 is a determinant of the age at onset of Alzheimer's and Parkinson's diseases; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Interaction between GSTM monomers and ASK1 with regulatory function; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Interaction between GSTM monomers and ASK1 with regulatory function; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Interaction between GSTM monomers and ASK1 with regulatory function; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Interaction between GSTM monomers and ASK1 with regulatory function; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. Interaction between GSTM monomers and ASK1 with regulatory function; all the catalytically active GSTs contribute to the glutathione conjugation or glutathione dependant-biotransformation of xenobiotics and many catalyze glutathione peroxidase or thiol transferase reactions. GSTs also catalyze glutathione dependent isomerization reactions required for the synthesis of several prostaglandins and steroid hormones and the catabolism of tyrosine, additional GST physiological functions, overview. The Pi class GST occurs in a monomer-dimer equilibrium and monomers can bind to and regulate other proteins such as JNK and TRAF
physiological function
glutathione S-transferases form a superfamily of multifunctional proteins with essential roles in cellular detoxification processes. GST5118 of Phanerochaete chrysosporium can function as a classical GST through the addition of glutathione mainly to phenethyl isothiocyanate, but alternatively and in a competitive way, it can also act as a ligandin of wood extractive compounds
physiological function
-
overexpression of human GSTA1-1 in tumor cells is part of multi drug resistance mechanisms
physiological function
-
GSTs functioning in the transport of secondary metabolites, e.g. of the electrophilic oxylipins. Pi class GSTs have assumed such roles in modulating the activity of Jun NH2-terminal kinase through protein-protein interactions. Tau class protein AtGSTU20 is a binding partner of the far-red insensitive 219 protein, such that alterations in its expression give rise to an altered growth phenotype under continuous far-red light. AtGSTF12, in which the catalytic serine is replaced by a non-proton abstracting residue resulting in abolished transferase activity, is necessary for correct anthocyanin pigment formation in developing Arabidopsis seeds, although their function is not related to GSH conjugation. Sometimes, following GST action, S-glutathionylated xenobiotics are imported into the vacuole by ATP-binding cassette (ABC) transporter proteins. In the GST family members where the catalytic serine is replace with a cysteine, the GSTs show the ability to co-ordinately bind hydrophobic ligands in close proximity to the reactive thiol of GSH
physiological function
-
AtuGSTH1-1 may play an important regulatory role in stress defence mechanism
physiological function
-
posttranslational S-glutathionylation modifications and glutaredoxin-dependent deglutathionylation participate in the regulation of metabolism and redox signalling in most organisms. Thiol-dependent reductase I, TDR1, an enzyme found in parasitic Leishmania species and Trypanosoma cruzi, is implicated in deglutathionylation and activation of antimonial prodrugs used to treat leishmaniasis. The deglutathionylation activity of TDR1 implies that glutathione itself has regulatory intracellular roles in addition to being a precursor for trypanothione, the major low mass thiol present in trypanosomatids
physiological function
Agrobacterium tumefaciens C58
-
AtuGSTH1-1 may play an important regulatory role in stress defence mechanism
-
physiological function
Rattus norvegicus Sprague-Dawley
-
role of mtMGST1 in the oxidant peroxynitrite-induced mitochondrial permeability transition, MPT, pore opening, peroxynitrite induces the swelling of mitoplasts (inner membranes including the matrix) as well as of the mitochondria. mtMGST1, ADP (an adenine nucleotide translocator),and cyclosporin A function as a MPT pore in peroxynitrite-induced swelling, in which the Ca2+ released by peroxynitrite might play an important role in the complex formation
-
metabolism
-
GST reaction products as metabolic intermediates, e.g. delivering the sullfur in the compounds, possible role for glutathione and GSTs in sulfur incorporation, detailed overview
additional information
the substrate binding pocket of MdGST6B, involving Arg113 and Phe121 on helix 4, is narrower compared to other delta- and epsilon-class GSTs, structure, overview. The Arg113 hydrogen bond does not play a crucial role in catalysis
additional information
-
G-site and H-site structure analysis and modeling, overview
additional information
role of conserved residues Ser13, Asn48 and Pro49 in the catalytic mechanism of the tau class glutathione transferase, overview
additional information
-
residues Ser11, Gln51, His52, Ser67, and Arg68 of the N-terminal domain are important for catalytic enzyme function, active site structure, overview
additional information
GSTT1-1 deficiency as the result of a gene deletion is common and is not deleterious
additional information
-
role for mutant Cys in mutant M212C in the transnitrosylation reaction with cyanoDMNG, while the Cys residue is not required in the aromatic substitution with 1-chloro-2,4-dinitrobenzene, for epoxide opening with NPG, and for addition to the ortho-quinone with aminochrome
additional information
-
structure of G-site active center amino acids of GSTM1-1, GSTP1-1, and GSTA1-1, mechanism comparison of isozymes, overview. Analysis of the GSH activation mechanism of GSTP1-1 and GSTM1-1 isoenzymes, overview. For the GSTP1-1 enzyme, a water molecule, after an initial conformational rearrangement of GSH, can assist a proton transfer between the GSH cysteine thiol and the GSH glutamate alpha carboxylate groups. The GSTM1-1 enzyme shows a completely different behavior from isoenzyme GSTP1-1, here two water molecules, positioned between the GSH-SH and the zeta N atom of His107, working like a bridge, are able to promote the proton transfer between these two active groups
additional information
-
where GSTs are involved in conjugating acceptors with GSH, there is an absolute requirement for the conserved serine residue within the active site, as it promotes the formation of the thiolate anion of GSH. In some family members this serine is replaced with a cysteine, e.g. promoting disulfide exchange reactions in the GSTL
additional information
-
AtuGSTH1-1 lacks the classic catalytic essential residues (Tyr, Ser, Cys) and has instead of the classic catalytic residues, an Arg residue (Arg34), an electron-sharing network, and a bridge of a network of water molecules may form the basis of the catalytic mechanism, Phe22, Ser25, and Arg187 are additional important residues for the enzyme's catalytic efficiency and specificity, overview. GSH binding site, G-site, and electrophilic binding site, H-site, structures, overview. In contrast to other GSTs where the H-site involves C-terminal domain residues, interactions in AtuGSTH1-1 are mainly provided by Arg187 and the long turn between strand b1 andhelix H1, residues 25-33
additional information
-
contribution of different residues in the GSH-binding site to GSH activation, structure analysis of wild-type and mutant enzymes by circular dichroism and fluorospectroscopic analysis, overview
additional information
Agrobacterium tumefaciens C58
-
AtuGSTH1-1 lacks the classic catalytic essential residues (Tyr, Ser, Cys) and has instead of the classic catalytic residues, an Arg residue (Arg34), an electron-sharing network, and a bridge of a network of water molecules may form the basis of the catalytic mechanism, Phe22, Ser25, and Arg187 are additional important residues for the enzyme's catalytic efficiency and specificity, overview. GSH binding site, G-site, and electrophilic binding site, H-site, structures, overview. In contrast to other GSTs where the H-site involves C-terminal domain residues, interactions in AtuGSTH1-1 are mainly provided by Arg187 and the long turn between strand b1 andhelix H1, residues 25-33
-
SUBSTRATE
PRODUCT                      
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid + HBr
show the reaction diagram
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
show the reaction diagram
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
show the reaction diagram
-
12% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
show the reaction diagram
-
-
-
-
?
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
show the reaction diagram
-
2.3% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(2,3-dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid + glutathione
?
show the reaction diagram
-
i.e. ethacrynic acid
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
show the reaction diagram
-
-
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
show the reaction diagram
-
4.6% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
show the reaction diagram
-
-
-
-
?
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
show the reaction diagram
-
8% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
?
show the reaction diagram
detoxification of the insecticide DDT, especially by isozyme agGSTe2
-
-
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
1,1-dichloro-2,2-bis-(4-chlorophenyl)ethylene + ?
show the reaction diagram
i.e. DDT, modeling of DDT into the putative DDT-binding pocket, catalytic mechanism of isozyme agGSTe2 that shows high activity through the inclination of the upper part of H4 helix, H4'' helix, which brings residues Arg112, Glu116, and Phe120 closer to the GSH-binding site resulting in a more efficient GS- stabilizing hydrogen-bond-network and higher DDT-binding affinity, overview
product formation through an elimination reaction triggered by the nucleophilic attack of the thiolate group of GS- on the beta-hydrogen of DDT
?
1,2-dichloro-4-nitrobenzene + glutathione
S-(2-chloro-4-nitro-phenyl)glutathione + HCl
show the reaction diagram
binding structure with wild-type and mutant Y119E and F123A enzymes, overview
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
show the reaction diagram
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
show the reaction diagram
-
-
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
show the reaction diagram
-
at 8% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
show the reaction diagram
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
show the reaction diagram
-
-
-
-
?
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
show the reaction diagram
-
-
-
-
?
1,2-epoxy-3-(p-nitrophenoxy)propane + glutathione
?
show the reaction diagram
-
-
-
-
?
1,2-epoxy-3-(p-nitrophenoxy)propane + GSH
?
show the reaction diagram
-
-
-
-
?
1,3,5-triacryloyl-1,3,5-triazinane + glutathione
L-gamma-glutamyl-S-[3-(3,5-diacryloyl-1,3,5-triazinan-1-yl)-3-oxopropyl]-L-cysteinylglycine
show the reaction diagram
-
-
-
?
1,3,5-trinitrobenzene + glutathione
S-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione
show the reaction diagram
an anionic sigma-complex is formed between GSH and 1,3,5-trinitrobenzene and is stabilized by Arg15. The trinitrocyclohexadienate moiety of the sigma-complex binds the H-site where the catalytic residue, Tyr9, was identified to hydrogen bond to an o-nitro group of the sigma-complex
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
show the reaction diagram
-
-
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
show the reaction diagram
-
-
-
-
?
1-bromo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HBr
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
?
show the reaction diagram
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
?
show the reaction diagram
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
?
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
best substrate
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
1-chloro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
aromatic substitution
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
synthetic substrate of GST
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
Sus scrofa Yorkshire pig
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
Agrobacterium tumefaciens C58
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
chloride + L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)-glutathione + HCl
show the reaction diagram
Tyr119 not only plays a role in hydrophobic substrate binding but also in packing of the active site pocket, which influences chemical interactions involved in enzyme catalysis
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
show the reaction diagram
residue Ser13 is directly involved in the reaction chemistry and the correct positioning of GSH and CDNB in the ternary catalytic complex. Asn48 and Pro49 have a direct role on the structural integrity of the GSH-binding site (G-site)
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
show the reaction diagram
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
show the reaction diagram
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
?
show the reaction diagram
Serratia marcescens CIP 6755
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
show the reaction diagram
Bemisia tabaci, Bemisia tabaci SUD-S
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
Proteus mirabilis AF 2924
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
Syrphus ribesii, Myathropa florea
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
Enterobacter cloacae CIP 6085, Proteus vulgaris ATCC8427
-
-
-
?
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
Sarcoptes scabiei ssGST3
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
show the reaction diagram
-
-
-
?
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
show the reaction diagram
-
1-fluoro-2,4-dinitrobenzene is conjugated through a classic SNAr reaction that proceeds in two steps with the formation of an intermediate Meisenheimer complex
-
?
1-iodo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HI
show the reaction diagram
-
-
-
?
1-methyl-4-nitro-5-[(4-nitrophenyl)thio]-1H-imidazole + glutathione
?
show the reaction diagram
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
10-S-glutathionyl-12-oxo-phytodienoic acid + H2O
show the reaction diagram
-
-
-
?
2,3-hexadienal + GSH
?
show the reaction diagram
-
at 7.5% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
show the reaction diagram
Syrphus ribesii, Myathropa florea
-
-
-
?
2-chloro-5-nitropyridine + glutathione
chloride + L-gamma-glutamyl-S-(5-nitropyridin-2-yl)-L-cysteinylglycine
show the reaction diagram
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
show the reaction diagram
-
HCCA isomerase catalyzes the glutathione-dependent interconversion of 2-hydroxychromene-2-carboxylic acid and trans-o-hydroxybenzylidene pyruvic acid in the naphthalene catabolic pathway of Pseudomonas putida, mechanisms in the naphthalene catabolic pathwayoverview, the dimeric protein binds one molecule of GSH very tightly and a second molecule of GSH with much lower affinity, GSH acts as a tightly bound cofactor in the reaction, binding structure, overview
-
?
2-hydroxyethyl disulfide + glutathione
?
show the reaction diagram
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
show the reaction diagram
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
show the reaction diagram
-
-
-
-
?
2-hydroxyethyl disulfide + glutathione
?
show the reaction diagram
Agrobacterium tumefaciens C58
-
-
-
-
?
3,4-dichloronitrobenzene + glutathione
?
show the reaction diagram
-
-
-
?
4-chloro-7-nitrobenzofurazan + glutathione
?
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
show the reaction diagram
-
-
-
-
?
4-hydroxynonenal + glutathione
?
show the reaction diagram
-
-
-
?
4-hydroxynonenal + GSH
?
show the reaction diagram
-
10% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
4-hydroxynonenal + GSH
?
show the reaction diagram
-
90% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
4-nitrobenzyl chloride + glutathione
?
show the reaction diagram
-
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
show the reaction diagram
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
4-nitrobenzyl chloride is conjugated through a single-step bimolecular nucleophilic substitution (SN2) with a pentacoordinate intermediate
-
?
4-nitrophenethyl bromide + glutathione
?
show the reaction diagram
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
show the reaction diagram
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
?
show the reaction diagram
-
-
-
-
?
4-nitrophenethyl bromide + glutathione
S-(4-nitrophenyl)glutathione + HBr
show the reaction diagram
-
-
?
4-nitrophenyl acetate + glutathione
?
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + GSH
?
show the reaction diagram
0.2% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
4-nitrophenyl acetate + GSH
?
show the reaction diagram
-
198% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
4-nitrophenyl acetate + GSH
?
show the reaction diagram
-
at 0.2% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
4-nitrophenyl butyrate + glutathione
S-(4-nitrophenyl)glutathione + butyrate
show the reaction diagram
-
-
?
4-nitrophenylacetate + glutathione
?
show the reaction diagram
-
-
-
-
?
4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
5-androstene-3,17-dione + glutathione
?
show the reaction diagram
Sus scrofa, Sus scrofa Yorkshire pig
-
-
-
?
5-pregnene-3,20-dione + glutathione
?
show the reaction diagram
Sus scrofa, Sus scrofa Yorkshire pig
-
-
-
?
5-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
show the reaction diagram
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
7-chloro-4-glutathionylbenzo-2-oxa-1,3-diazole
show the reaction diagram
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
-
15% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
23.4% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
-
80% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
-
at 23% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
7-oxabicyclo[4.1.0]heptan-2-one + glutathione
chloride + L-gamma-glutamyl-S-(6-oxocyclohex-1-en-1-yl)-L-cysteinylglycine
show the reaction diagram
-
-
-
?
alachlor + glutathione
?
show the reaction diagram
-
-
-
-
?
allyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
allyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
aminochrome + glutathione
?
show the reaction diagram
-
-
-
-
?
androstenedione + glutathione
?
show the reaction diagram
-
-
-
-
?
atrazine + glutathione
?
show the reaction diagram
-
-
-
-
?
atrazine + glutathione
atrazine-S-glutathione + HCl
show the reaction diagram
-
-
-
?
azathioprine + glutathione
?
show the reaction diagram
-
aromatic substitution. Wild-type hGST M2-2 has modest activity with azathioprine, but mutant C87A/C115A/C174A/M212C displays no detectable activity. The azathioprine activity of wild-type hGST M2-2 can be enhanced 30fold by two point mutations of other residues in the active site
-
-
?
benzyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
benzyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
?
bromosulfophthalein + glutathione
?
show the reaction diagram
-
-
-
-
?
bromosulfophthalein + GSH
?
show the reaction diagram
-
10.3% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II, 8.6% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
brostallicin + glutathione
glutathionyl-brostallicin
show the reaction diagram
-
involved in activation of the prodrug, mechanism, overview. The reaction proceeds via the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug, brostallicin cytotoxicity of brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene, isoenzymes GSTP1-1 and GSTM2-2
-
?
butyl nitrite + glutathione
?
show the reaction diagram
-
-
-
-
?
chlorofluoroacetic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
106% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I, 11.9% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II
-
-
?
cumene hydroperoxide + GSH
?
show the reaction diagram
-
18% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
dehydroascorbate + glutathione
?
show the reaction diagram
-
-
-
-
?
dehydroascorbic acid + glutathione
?
show the reaction diagram
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
show the reaction diagram
-
-
-
-
?
dichloroacetic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
dichloroacetic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + glutathione
?
show the reaction diagram
-
ethacrynic acid is conjugated via a Michael addition reaction through the formation of an enole intermediate
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
-
-
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
-
15% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
-
24% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
8% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
-
9% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
ethacrynic acid + GSH
?
show the reaction diagram
-
at 8% of the activity with 1-chloro-2,4-dinitrobenzene, wild-type enzyme
-
-
?
fluazifop-p-butyl + glutathione
?
show the reaction diagram
-
-
-
-
?
fluorodifen + glutathione
?
show the reaction diagram
-
-
-
-
?
glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
-
preferred polychlorinated biphenyl metabolite substrate
-
?
glutathione + (2Z,4E)-3-chloro-6-(3,5-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + (R)-styrene-7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (R,R)-1-phenylpropylene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (R,R)-trans-stilbene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S)-styrene-7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S,S)-1-phenylpropylene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S,S)-trans-stilbene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
weak substrate
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
at a low rate
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
enzyme MIII
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
low activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
substrate of the mu class isozyme
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
substrate of the liver enzyme, no activity by the gill enzyme
-
-
?
glutathione + 1,2-diiodoethane
?
show the reaction diagram
-
best substrate
-
-
?
glutathione + 1,2-diiodoethane
?
show the reaction diagram
best substrate
-
-
?
glutathione + 1,2-dinitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dinitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitro-phenoxy)propane
?
show the reaction diagram
-
best substrate for the wild-type GST T1-1 and mutant W234K
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
anionic isozyme
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
-
isoenzyme E
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)-propane
?
show the reaction diagram
-
substrate of the theta class isozyme
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
show the reaction diagram
-
-
-
?
glutathione + 1,4-diiodobutane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,4-diiodobutane
?
show the reaction diagram
-
-
-
?
glutathione + 1,6-diiodohexane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,6-diiodohexane
?
show the reaction diagram
-
-
-
?
glutathione + 1,8-diiodooctane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,8-diiodooctane
?
show the reaction diagram
-
-
-
?
glutathione + 1-bromo-4-nitrobenzene
bromide + 4-nitrophenyl-glutathione
show the reaction diagram
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
enzyme has only weak activity towards the substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
low activity towards the substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
preferred substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
preferred substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
high activity with isozyme GSTO2, not with isozyme GSTO1-1
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
i.e. CDNB
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
substrate binding structure, overview
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
substrate of mu, pi, theta, alpha, and tau class isozymes
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
substrate specificity of enzyme from bees of different subspecies differ, overview
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
Mus musculus BALB/c
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
Mus musculus CD1
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
best substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
preferred substrate
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
the catalytic activity of purified GST from Nanyang city population with GSH is much higher than the activity of the enzyme from other populations, while the Wuzhou population reaches the highest in Vmax for substrate 1-chloro-2,4-dinitrobenzene
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
SNAr reaction between GSH and 1-chloro-2,4-dinitrobenzene. Role of Arg15 in the binding and activation of GSH and in sigma-complex formation, overview
-
?
glutathione + 1-fluoro-2,4-dinitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodo-3-phenylpropane
iodide + 3-phenylpropyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodoethane
iodide + ethylglutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodoheptane
iodide + heptyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodohexane
iodide + hexyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodohexane
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodohexane
?
show the reaction diagram
-
-
-
?
glutathione + 1-iodomethane
iodide + methylglutathione
show the reaction diagram
-
best substrate of GST T1-1 mutant W234R
-
?
glutathione + 1-iodooctane
iodide + octyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodopentane
iodide + pentyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-iodopropane
iodide + propyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-menaphthyl sulfate
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
show the reaction diagram
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
show the reaction diagram
-
-
-
?
glutathione + 2,4-hexadienal
?
show the reaction diagram
-
-
-
?
glutathione + 2,5-dinitrophenol
?
show the reaction diagram
-
-
-
-
?
glutathione + 2-hydroxyethyl disulfide
?
show the reaction diagram
isozyme GSTO2, low activity
-
-
?
glutathione + 2-methyl-4-nitrobenzyl alcohol
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dinitrobenzanilide
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + 3-iodopropylbenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 3-iodopropylbenzene
?
show the reaction diagram
-
-
-
?
glutathione + 4-chloro-3-nitroacetophenone
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-chloro-3-nitrobenzophenone
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
?
glutathione + 4-fluoro-3-nitrobenzanilide
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-hydroxydecenal
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynonenal
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-hydroxynonenal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynonenal
?
show the reaction diagram
-
-
-
?
glutathione + 4-hydroxynonenal
?
show the reaction diagram
a lipid peroxidation product
-
-
?
glutathione + 4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
weak substrate
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrophenyl-glutathione
show the reaction diagram
-
substrate of the alpha class isozyme
-
?
glutathione + 4-nitrobenzyl chloride
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzylchloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenethyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 4-nitrophenethyl bromide
?
show the reaction diagram
weak substrate
-
-
?
glutathione + 4-nitrophenyl acetate
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrophenyl acetate
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
-
?
glutathione + 4-nitrophenyl bromide
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitropyridine
?
show the reaction diagram
-
-
-
-
?
glutathione + 5-nitrofurfural
?
show the reaction diagram
-
-
-
-
?
glutathione + 5-nitrofurfural
?
show the reaction diagram
-
-
-
-
?
glutathione + 5-nitrofurfural diacetal
?
show the reaction diagram
-
-
-
-
?
glutathione + 5-nitrofurfural diacetal
?
show the reaction diagram
-
-
-
-
?
glutathione + 7-amino-4-chloromethyl coumarin
?
show the reaction diagram
-
-
-
?
glutathione + 7-amino-4-chloromethyl coumarin
?
show the reaction diagram
-
isozyme GSt T2-2 shows high activity
-
-
?
glutathione + 7-chloro-4-nitrobenz-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
poor substrate
-
-
?
glutathione + acetochlor
?
show the reaction diagram
-
-
-
-
?
glutathione + acrolein
?
show the reaction diagram
-
-
-
-
?
glutathione + adenine propenal
?
show the reaction diagram
-
-
-
-
?
glutathione + alachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + alachlor
?
show the reaction diagram
-
herbicide
-
-
?
glutathione + alachlor
?
show the reaction diagram
-
i.e. 2-chloro-N-(2,6-diethylphenyl)-N-(methoxymethyl)acetamide
-
-
?
glutathione + alachlor
?
show the reaction diagram
-
isozyme GSTI, i.e. 2-chloro-N-[2,6-diethylphenyl]-N-[methoxymethyl]acetamide, isozyme GSTI
-
-
?
glutathione + allyl-isothiocyanate
?
show the reaction diagram
-
-
-
-
?
glutathione + allyl-isothiocyanate
?
show the reaction diagram
-
-
-
?
glutathione + androst-5-ene-3,17-dione
?
show the reaction diagram
-
-
-
-
?
glutathione + anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + atrazine
?
show the reaction diagram
-
herbicide
-
-
?
glutathione + atrazine
?
show the reaction diagram
-
high specific activity
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
show the reaction diagram
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
show the reaction diagram
-
-
-
?
glutathione + azathioprine
6-mercaptopurine + ?
show the reaction diagram
-
-
?
glutathione + benzo[a]pyrene 4,5-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + benzo[a]pyrene 4,5-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + benzyl isothiocyanate
?
show the reaction diagram
-
substrate of GSTF9
-
-
?
glutathione + bromosulfophthalein
?
show the reaction diagram
-
-
-
-
?
glutathione + bromosulfophthalein
?
show the reaction diagram
-
-
-
-
?
glutathione + bromosulphthalein
?
show the reaction diagram
-
-
-
?
glutathione + bromosulphthalein
?
show the reaction diagram
-
-
-
?
glutathione + butachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + chlorambucil
?
show the reaction diagram
-
-
-
-
?
glutathione + cis-6-(2-acetylvinylthio)purine
?
show the reaction diagram
-
-
-
?
glutathione + cryptophycin 52
?
show the reaction diagram
-
conjugation with the R-stereoisomer
-
-
?
glutathione + cryptophycin 53
?
show the reaction diagram
-
conjugation with the S-stereoisomer
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
isozyme MI
-
-
?
glutathione + cumene hydroperoxide
?
show the reaction diagram
-
the enzyme has selenium-independent peroxidase activity
-
-
?
glutathione + cyclohexyl-isothiocyanate
?
show the reaction diagram
-
-
-
-
?
glutathione + cyclohexyl-isothiocyanate
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
low activity
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
weak substrate
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
low activity towards substrate
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
low activity compared to 1-chloro-2,4-dinitrobenzene
-
-
?
glutathione + ethacrynic acid
?
show the reaction diagram
-
substrate of the pi class isozyme
-
-
?
glutathione + ethylene diiodide
?
show the reaction diagram
-
-
-
?
glutathione + fenchlorim
?
show the reaction diagram
-
-
-
-
?
glutathione + fenoxaprop
4-hydroxyphenoxypropanoic acid + glutathione conjugate
show the reaction diagram
-
herbicide
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
-
-
-
?
glutathione + fluorodifen
?
show the reaction diagram
-
substrate of the tau class isozyme
-
-
?
glutathione + fluorodifen
4-nitrophenol + (2-nitro-4-trifluoromethylphenyl)glutathione
show the reaction diagram
-
-
-
?
glutathione + H2O2
?
show the reaction diagram
-
-
-
?
glutathione + hematin
?
show the reaction diagram
GST-1 is involved in parasite heme detoxification during hemoglobin digestion or heme uptake
-
-
?
glutathione + hematin
?
show the reaction diagram
high affinity binding by GST-1
-
-
?
glutathione + hexa 2,4-dienal
?
show the reaction diagram
-
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
-
-
-
?
glutathione + hydroxyethyldisulfide
?
show the reaction diagram
-
-
-
-
?
glutathione + indomethane
?
show the reaction diagram
-
-
-
-
?
glutathione + indomethane
?
show the reaction diagram
-
-
-
-
?
glutathione + iodomethane
?
show the reaction diagram
-
-
-
-
?
glutathione + iodomethane
?
show the reaction diagram
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
show the reaction diagram
-
-
-
-
-
glutathione + linoleic acid hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + linoleic acid hydroperoxide
?
show the reaction diagram
-
cationic isozyme
-
-
?
glutathione + metolachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + metolachlor
?
show the reaction diagram
-
herbicide
-
-
?
glutathione + metolachlor
?
show the reaction diagram
-
herbicide
-
-
?
glutathione + microcystin-LR
?
show the reaction diagram
-
-
-
-
?
glutathione + microcystin-LR
?
show the reaction diagram
-
cyanobacterial toxins are hypothesized to contribute to the mortality of prawns, many aquatic organisms have the possibility of detoxifying cyanobacterial toxins, e.g. nodularin or microcystin-LR, via conjugation to glutathione, a cyanobacterial toxin
-
-
?
glutathione + naphthalene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + nitrobutyl chloride
chloride + nitrobutyl-glutathione
show the reaction diagram
-
-
?
glutathione + nodularin
?
show the reaction diagram
-
cyanobacterial toxins are hypothesized to contribute to the mortality of prawns, many aquatic organisms have the possibility of detoxifying cyanobacterial toxins, e.g. nodularin or microcystin-LR, via conjugation to glutathione, a cyanobacterial toxin
-
-
?
glutathione + petrilachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + phenethyl-isothiocyanate
?
show the reaction diagram
-
-
-
-
?
glutathione + phenethyl-isothiocyanate
?
show the reaction diagram
-
-
-
?
glutathione + pretilachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
show the reaction diagram
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
show the reaction diagram
-
-
-
?
glutathione + styrene 7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + styrene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + styrene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + sulforaphane
?
show the reaction diagram
-
-
-
-
?
glutathione + sulforaphane
?
show the reaction diagram
-
-
-
?
glutathione + terbuthylazine
?
show the reaction diagram
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + tert-butyl hydroperoxide
?
show the reaction diagram
-
anionic isozyme
-
-
?
glutathione + trans,trans-2,4-decadienal
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
-
-
?
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
-
low activity
-
-
?
glutathione + trans-4-phenyl-3-butene-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-6-(2-acetylvinylthio)guanine
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
-
-
-
?
GSH reductase + GSH
?
show the reaction diagram
-
271% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II, 87% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
harderoporphyrinogen + glutathione
harderoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-
-
-
?
hydrogen peroxide + glutathione
?
show the reaction diagram
-
-
-
-
?
iodobutane + glutathione
?
show the reaction diagram
-
-
-
-
?
iodohexane + glutathione
?
show the reaction diagram
-
-
-
-
?
iodomethane + glutathione
?
show the reaction diagram
-
-
-
-
?
maleylacetone + glutathione
?
show the reaction diagram
-
-
-
-
?
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate + glutathione
chloride + L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine
show the reaction diagram
-
-
-
?
metolachlor + glutathione
?
show the reaction diagram
-
-
-
-
?
monochlorobimane + glutathione
bimane-glutathione + HCl
show the reaction diagram
-
-
-
?
nitrophenyl acetate + GSH
?
show the reaction diagram
-
6.5% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
nonenal + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
Sus scrofa Yorkshire pig
-
-
-
?
propyl isothiocyanate + glutathione
?
show the reaction diagram
-
-
-
-
?
protoporphyrinogen + glutathione
protoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-
-
-
?
rac-4-hydroxynonenal + glutathione
S-(4-hydroxy-1-oxononan-3-yl)glutathione
show the reaction diagram
-
elimination of the lipid peroxidation product 4-hydroxynonenal, a toxic compound that contributes to numerous diseases
-
?
rac-4-hydroxynonenal + glutathione
S-[(2S)-3-hydoxy-2-(2-oxoethyl)octyl]glutathione
show the reaction diagram
-
GSTA1-1 isoform has poor catalytic efficiency with 4-hydroxynonenal, GSTA4-4 has negligible stereoselectivity towards the two 4-hydroxynonenal enantiomers, despite its high catalytic chemospecificity for alkenals
product binding, overview
?
reduced glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
reduced glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
?
reduced glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + 4-nitrophenethyl bromide
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
show the reaction diagram
-
-
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
-
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange
-
?
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
participates in detoxification
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
involved both with bilirubin transport and detoxification of electrophils
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
biotransformation and detoxification of electrophilic xenobiotics
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
phase II detoxification mechanism, isomerization of 3-ketosteroids and biosynthesis of peptide leukotrienes
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
detoxification of electrophilic products of cytochrome P-450-dependent reactions, toxic catabolite of heme, bilirubin is bound and thereby neutralized
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
detoxification of products of oxidative metabolism, e.g. 4-hydroxyalkenals, epoxides, organic hydroperoxides
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
may be involved in preventing lipid peroxidation
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
microsomal enzyme is likely to be involved in drug metabolism
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-G
show the reaction diagram
-
first step in mercapturic acid synthesis
-
-
RX + glutathione
HX + R-S-glutathione
show the reaction diagram
-
-
-
?
styrene oxide + glutathione
?
show the reaction diagram
-
-
-
-
?
tertiary butyl hydroperoxide + glutathione
?
show the reaction diagram
-
-
-
-
?
trans-2-nonenal + glutathione
?
show the reaction diagram
-
-
-
-
?
trans-2-nonenal + glutathione
?
show the reaction diagram
-
-
-
?
trans-2-nonenal + glutathione
?
show the reaction diagram
-
-
-
?
trans-2-nonenal + GSH
?
show the reaction diagram
-
at 1% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
trans-4-phenyl-3-buten-2-one + glutathione
?
show the reaction diagram
-
-
-
-
?
trans-phenyl-butenone + GSH
?
show the reaction diagram
-
312% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme II, 71% of the activity with 1-chloro-2,4-dinitrobenzene, isoenzyme I
-
-
?
[(methylamino)[methyl(nitroso)amino]methyl]cyanamide + glutathione
[bis(methylamino)methyl]cyanamide + S-nitrosoglutathione
show the reaction diagram
-
transnitrosylation
-
?
[3-(4-nitrophenyl)oxiran-2-yl]methanol + glutathione
?
show the reaction diagram
-
-
-
-
?
monochlorobimane + GSH
?
show the reaction diagram
Bemisia tabaci, Bemisia tabaci SUD-S
-
-
-
-
?
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
-
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
specificity
-
-
-
additional information
?
-
-
conjugation of glutathione with base propenals and related alkenes, A1-1 and M1-1 are more active with 4-hydroxyalkenals than with base propenals
-
-
-
additional information
?
-
-
any compound bearing a sufficiently electrophilic atom may be attacked, reactions with C,S,N and O atoms are possible
-
-
-
additional information
?
-
-
enzyme has also activity towards reactive carbonyls
-
-
-
additional information
?
-
-
no substrate: bromosulfophthalein
-
-
-
additional information
?
-
-
no substrate: bromosulfophthalein
-
-
-
additional information
?
-
-
no substrate: bromosulfophthalein
-
-
-
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
-
-
-
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
-
-
-
additional information
?
-
-
no substrate: 4-nitrobenzyl chloride
-
-
-
additional information
?
-
-
enzyme has glutathione-dependent dehydroascorbate reductase and thiol transferase activity
-
-
-
additional information
?
-
-
no substrates: sulfobromophthalein and hydrogen peroxide
-
-
-
additional information
?
-
-
no substrate: 4-nitropyridine N-oxide
-
-
-
additional information
?
-
-
catalyzes the reaction of glutathione with a large number of compounds bearing an electrophilic carbon to form the corresponding thioether
-
-
-
additional information
?
-
-
isomerization of DELTA5- to DELTA4- unsaturated 3-keto steroids
-
-
-
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
-
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
-
additional information
?
-
-
no substrate: 1,2-epoxy-3-(4-nitrophenoxy)propane
-
-
-
additional information
?
-
-
obligate requirement for reduced glutathione as thiol donor
-
-
-
additional information
?
-
-
enzyme has also selenium-independent peroxidase activity
-
-
-
additional information
?
-
-
enzyme has also selenium-independent peroxidase activity
-
-
-
additional information
?
-
-
no substrate: trans-4-phenyl-3-buten-2-one
-
-
-
additional information
?
-
-
catalyzes S-conjugation between the thiol group of glutathione and an electrophilic moiety in the hydrophobic and toxic sustrate
-
-
-
additional information
?
-
-
no substrate: methyl iodide
-
-
-
additional information
?
-
-
GSTC: activity towards 1-chloro-2,4-dinitrobenzene, GSTF: activity towards the herbicide fluorodifen, GPOX: peroxidase activity, overview: xenobiotic substrates
-
-
-
additional information
?
-
-
no substrate: ethacrynic acid
-
-
-
additional information
?
-
-
assays for differentiation of glutathione S-transferase isoenzymes from rat and human by different specific acitivities with selected substrates
-
-
-
additional information
?
-
-
glutathione transferase X: no reaction of menaphthyl sulfate with glutathione, potent in inactivation of tert-10,11-epoxy-r-8,tert-9-dihydroxy-8,9,10,11-tetrahydrobenz/a/anthracene
-
-
-
additional information
?
-
-
bacterial enzyme represents a defence against the effects of antibiotics
-
-
-
additional information
?
-
-
detoxification protein protects against oxidative damage in certain aquatic organisms
-
-
-
additional information
?
-
-
GST isozymes play independent roles that characterize multiple processes within vomeronasal organ chemosensitivity
-
-
-
additional information
?
-
-
microsomal Ya-GST might be involved in the protection of membranes from peroxidative damage and its function is greatly affected by its localization in the membranes
-
-
-
additional information
?
-
-
the enzyme may play an important role in the protection of cellular membranes from peroxidative damage
-
-
-
additional information
?
-
Syrphus ribesii, Myathropa florea
-
the enzyme plays an important role in detoxification of many substances including organic pollutants and plant secondary metabolites
-
-
-
additional information
?
-
-
the enzyme plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity
-
-
-
additional information
?
-
-
the enzyme plays an importent role in stress tolerance and detoxification in plants
-
-
-
additional information
?
-
-
no activity with either bromosulfophthalein, ethacrynic acid, 1,2-epoxy-3-(p-nitrophenoxy)propane, cumene hydroperoxide or hydrogen peroxide
-
-
-
additional information
?
-
no activity with: cumene hydroperoxide, 1,2-dichloro-4-nitrobenzene, ethacrynic acid, 4-hydroxynonenal and p-nitrobenzyl chloride
-
-
-
additional information
?
-
-
the enzyme also exhibits glutathione peroxidase activity towards cumene hydroperoxide
-
-
-
additional information
?
-
a phase II detoxification enzyme which protect against chemical injury, especially in the context of detoxifying waterborne pollutants
-
-
-
additional information
?
-
-
a primary pathway for metabolism of electrophilic compounds in Schistosoma japonicum involves glutathione S-transferase-catalyzed formation of glutathione conjugates, overview, production of nonenzymatic GSH conjugates with electrophilic substrates often overwhelms the activity of the enzyme, overview
-
-
-
additional information
?
-
-
benoxacor, fenclorim, and fluxofenim do not protect the plant from herbicide injury but induce RNA expression of the glutathione-conjugate transporters encoded by genes AtMRP1, AtMRP2, AtMRP3, and AtMRP4
-
-
-
additional information
?
-
GST may play a role in the pathophysiology associated with crusted scabies
-
-
-
additional information
?
-
-
infection of skeletal muscle with Trichinella spiralis affects the Km of the enzyme due to alterations of the enzyme's quarternary structure, overview
-
-
-
additional information
?
-
-
isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview
-
-
-
additional information
?
-
isozyme GSTO2 may play an important role in cellular signaling inducing apoptosis
-
-
-
additional information
?
-
-
the enzyme catalyzes the dehalogenation of inhibitory metabolites of polychlorinated biphenyls and may be responsible for facilitation of PCB degradation by the bph pathway, overview
-
-
-
additional information
?
-
the enzyme is essential for parasite survival by protecting the parasite against oxidative stress and buffering the detoxification of heme-binding compounds
-
-
-
additional information
?
-
-
the enzyme is involved in phase II detoxication processes by conjugation of a thiol group from reduced glutathione to an electrophilic centre of diverse xenobiotic compounds, producing less reactive and more polar substances in order to facilitate elimination from cells
-
-
-
additional information
?
-
the enzyme is the major detoxification enzyme of Schistosoma japonicum, a pathogenic helminth causing schistosomiasis
-
-
-
additional information
?
-
-
the soluble enzyme is an essential detoxification enzyme in parasitic species
-
-
-
additional information
?
-
2-nitrophenyl acetate, bromosulfophthalein, and cumene hydroperoxide are poor substrates, overview
-
-
-
additional information
?
-
-
artemisinin is no substrate for glutathione transferase activity but for peroxidase activity, as is cumene hydroperoxide
-
-
-
additional information
?
-
-
enzyme ligand binding site structure, overview
-
-
-
additional information
?
-
-
glutathione binds in the G site of the isozyme GST-A1-1, glutathione binding alone is sufficient to stabilize the C-terminal helix of the protein
-
-
-
additional information
?
-
-
isozyme-dependent tissue-specific substrate specificity, overview
-
-
-
additional information
?
-
-
mu- and pi-class GST activities
-
-
-
additional information
?
-
-
no activity with 4-nitrobenzylchloride, no activity with 4-nitrobenzylchloride, GSTF9 also shows glutathione peroxidase activity, EC 1.11.1.9, overview
-
-
-
additional information
?
-
-
substrate specificity of wild-type and mutant isozymes GST T1-1, overview
-
-
-
additional information
?
-
substrate specificity, overview, poor activity with cumene hydroperoxide, 4-hydroxynonenal, methyl parathion or atrazine
-
-
-
additional information
?
-
-
the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview
-
-
-
additional information
?
-
-
the enzyme shows nearly no glutathione peroxidase activity
-
-
-
additional information
?
-
the recombinant enzyme shows no activity with 1-chloro-2,4-dinitrobenzene, but is highly active with 9(S)-hydroperoxy-(10E,12Z,15Z)-octadecatrienoic acid, cumene hydroperoxide, and other hydroperoxide substrates as glutathione peroxidase, EC 1.11.1.9, overview
-
-
-
additional information
?
-
-
the selenomethionine-labeled antibody fragment ScFv2F3 is catalytically inactive
-
-
-
additional information
?
-
-
the wild-type dimeric form is not required for catalytic activity
-
-
-
additional information
?
-
1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates
-
-
-
additional information
?
-
1,2-epoxy-3-(4-nitrophenoxy) propane is no substrate
-
-
-
additional information
?
-
bromosulphthalein and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates
-
-
-
additional information
?
-
cannot utilize cis-6-(2-acetylvinylthio)purine and trans-6-(2-acetylvinylthio)purine
-
-
-
additional information
?
-
-
does not use acifluorofen, fluorodifen, metochlor, and pretilachlor as a substrate
-
-
-
additional information
?
-
no activity detected with ethacrynic acid, cumene hydroperoxide, and H2O2
-
-
-
additional information
?
-
-
no activity towards bromosulphophthalein, 1,2-dichloro-4-nitrobenzene, ethacrynic acid, 1,2-epoxy-2(p-nitrophenoxy) propane, trans-non-2-enal, and hexa-2,4-dienal
-
-
-
additional information
?
-
-
no activity towards hydrogen peroxide, bromosulfophthalein, and 1,2-dichloro-4-nitrobenzene
-
-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrobenzyl chloride, and 4-nitrophenethyl bromide
-
-
-
additional information
?
-
no activity with 1,2-dichloro-4-nitrobenzene, iodomethane, 1-iodopenthane, and dichloromethane
-
-
-
additional information
?
-
-
no activity with 1,2-dichloro-4-nitrobenzene, iodomethane, 1-iodopenthane, H2O2, trans-2-nonenal, and dichloromethane
-
-
-
additional information
?
-
-
no activity with 1,2-epoxy-3-(p-nitrophenoxy)-propane and bromosulfophthalein
-
-
-
additional information
?
-
-
no activity with atrazine and acifluorofen
-
-
-
additional information
?
-
-
no activity with bromosulphathalein, 1,2-dichloro-4-nitrobenzene, t-butyl hydroperoxide, and linoleic hydroperoxide
-
-
-
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
-
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
-
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, ethacrynic acid, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
-
additional information
?
-
no detectable activity with 1,2-dichloro-4-nitrobenzene, hexa-2,4-dienal, and bromosulphthalein
-
-
-
additional information
?
-
no detectable activity with 1,2-epoxy-3-(4-nitrophenoxy) propane
-
-
-
additional information
?
-
-
pentafluorobenzanilide and 4-chloro-3-nitrobenzanilide are no substrates
-
-
-
additional information
?
-
-
GST as fusion expression partner enhances the solubility of recombinant proteins
-
-
-
additional information
?
-
-
the human isozyme GST T1-1 is 80fold less active than the murine isozyme GST T1-1
-
-
-
additional information
?
-
-
the murine isozyme GST T1-1 is 80fold more active than the human isozyme GST T1-1
-
-
-
additional information
?
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the regulation of GST enzymatic activity through a dimer-tetramer transition via GSH binding is an exclusive feature of Plasmodium, three-dimensional modeling, overview
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additional information
?
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1,2-dichloro-4-nitrobenzene and ethacrynic acid are no substrates
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additional information
?
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agGSTe2 has a long narrow cleft at the interface of the N- and C-domains, in which a GSH molecule tightly fits, binding of glutathione does not induce significant conformational changes in the isozyme agGSTe2 protein, structure, overview
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additional information
?
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Arg15, conserved in class alpha GSTs, is located at the interface between the G- and H-sites of the active site where its cationic guanidinium group might play a role in catalysis and ligand binding. Binding of the anionic non-substrate ligand 8-anilino-1-naphthalene sulfonate to the H-site involving residue Arg15. The sigma-complex 5-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione is an analogue of the anionic transition state of the SNAr reaction between S-(2,4-dinitrophenyl)glutathione and GSH, docking structure, overview
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additional information
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GST T1-1 displays both glutathione transferase and glutathione peroxidase enzyme activities, the latter with CuOOH
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additional information
?
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isozyme GSTA4-4 shows high catalytic chemospecificity for alkenals, but negligible stereoselectivity, GSTA4-4 undergoes no enantiospecific induced fit, mechanism of the combination of high substrate chemoselectivity and low substrate stereoselectivity, overview
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additional information
?
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MGST1 possesses glutathione transferase and peroxidase activity. Native MGST1 binds three GSH molecules per trimer but with different affinities for GSH, it possesses only one high affinity catalytically competent site per trimer, nanoelectrospray mass spectrometric analysis, overview
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additional information
?
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no activity with 1,2-dichloro-4-nitrobenzene, 4-nitrophenyl acetate, and ethacrynic acid
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additional information
?
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no activity with 1,2-dichloro-nitrobenzene
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additional information
?
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positive cooperativity upon GSH binding indicating that the residue replacement affects the communication between subunits of the dimeric enzyme
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additional information
?
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quantitative structure-activity relationship analyses, overview
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additional information
?
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recombinant isozymes GST-1, GST-2, and GST-3, expressed in Pichia pastoris, all exhibit low lipid peroxidase and glutathione-conjugating enzymatic activities but high heme-binding capacities
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additional information
?
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structure-activity relationships, overview
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additional information
?
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structure-function study of glutathione transferase-like proteins, overview
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additional information
?
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substrate specificity, overview. A major structural determinant of substrate recognition is the H-site, which binds the electrophile in proximity to the nucleophilic sulfur of the second substrate glutathione. H-site residue 234 has a key role in governing the activity and substrate selectivity profile of GST T1-1
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additional information
?
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the enzyme shows high affinity for organophosphorus insecticide
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additional information
?
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the recombinant cytosolic GST displays glutathione peroxidase activity towards cumene hydroperoxide, and conjugates reactive carbonyls, trans-2-nonenal and trans,trans-2,4-decadienal, indicating that it may intercept damaging products of lipid peroxidation
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additional information
?
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three recombinant theta class GSTs, GSTTs, show conserved activities as hydroperoxide-reducing glutathione peroxidases
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additional information
?
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glutathione conjugation reactions are often freely reversible, formation of unstable glutathionylated natural products in plants, the detection is difficult, overview
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additional information
?
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glutathione transferases from rat liver are able to conjugate GSH to many hydrophobic toxic compounds. Small and hydrophilic disulfides like cystine, cystamine and dithioethanol, and hydrophilic alkylating compounds like iodoacetate, are no substrates of this enzyme. Omega class GST and a peculiar lens GST display a moderate thiol transferase activity with dithioethanol
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additional information
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GSTO2-2 has strikingly high dehydroascobate reductase activity
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additional information
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GSTZ1 G42R mutant is shown to have high specific activity with the (R)-enantiomer of 2-chloropropionic acid and low activity with the (S)-enantiomer
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additional information
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interaction between GSTM monomers and ASK1
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additional information
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only isozymes GSTE2-2 and GSTE5-5 are able to metabolize DDT to DDE
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additional information
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thioltransferase and reductase reactions that are a feature of the Omega class GSTs
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additional information
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AtuGSTH1-1 exhibits significant transferase activity against the common substrates aryl halides, as well as very high peroxidase activity towards organic hydroperoxides
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additional information
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development of analytical quantification assays for pesticides dieldrin and spiromesifen in water with isozyme GSTA1-1, overview
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additional information
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fluazifop-inducible glutathione transferase isozymes catalyze a broad range of reactions and exhibit quite varied substrate specificity, molecular modeling and structural analysis reveal key structural characteristics, isozynme substrate specificities and catalytic mechanism, overview. Only PvGSTU2-2 shows appreciable activity towards trans-2-nonenal, but the isozymes are also active with cumene hydroperoxide, tert-butyl hydroperoxide, and lauroyl peroxide, no activity of all isozymes with benzoyl peroxide
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additional information
?
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GST5118 binds glutathionylated and sulfated compounds but also wood extractive molecules, such as vanillin, chloronitrobenzoic acid, hydroxyacetophenone, catechins, and aldehydes, in the glutathione pocket, overview. Glutathione binding structure and mechanism, detailed overview. The enzyme also shows peroxidase activity
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additional information
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GSTs selectively bind GSH
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additional information
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monochlorobimane and 1-chloro-2,4-dinitrobenzene are used to determine GST activity
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additional information
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overexpressed in bacteria, family members GSTF2 and GSTF3 bind a series of heterocyclic compounds, including lumichrome, harmane, norharmane and indole-3-aldehyde. GSTF2 also selectively binds the indole-derived phytoalexin camalexin, as well as the flavonol quercetin-3-O-rhamnoside, recombinant GSTF2 ligand binding studies and kinetics, overview
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additional information
?
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TDR1 displays weak GSTactivity with 1-chloro-2,4-dinitrobenzene, and a glutaredoxin-like thioltransferase activity, with hydroxyethyl disulfide, together with a previously noted dihydroascorbate reductase activity. The peptide substrate SQLWCLSN, with a bulky tryptophan adjacent to the cysteine, may not be optimal for binding to the sterically restricted G-I site on TDR1 leading to low deglutathionylation activity
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additional information
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the enzyme is active with cumene hydroperoxide. The GST A1-1 catalytic activity in steroid isomerization reactions is at least 10fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene is approximately 8fold higher. Differences in the H-site residues of mammalian Alpha-class GSTs may explain the catalytic divergence
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additional information
?
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YghU from Escherichia coli binds two molecules of GSH in each active site. YghU exhibits little or no GSH transferase activity with most typical electrophilic substrates but does possess a modest catalytic activity toward several organic hydroperoxides. The enzyme also exhibits disulfide-bond reductase activity towards 2-hydroxyethyl disulfide
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additional information
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Sus scrofa Yorkshire pig
the enzyme is active with cumene hydroperoxide. The GST A1-1 catalytic activity in steroid isomerization reactions is at least 10fold lower than the corresponding values for porcine GST A2-2, whereas the activity with 1-chloro-2,4-dinitrobenzene is approximately 8fold higher. Differences in the H-site residues of mammalian Alpha-class GSTs may explain the catalytic divergence
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additional information
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Proteus mirabilis AF 2924
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bacterial enzyme represents a defence against the effects of antibiotics
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additional information
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Agrobacterium tumefaciens C58
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AtuGSTH1-1 exhibits significant transferase activity against the common substrates aryl halides, as well as very high peroxidase activity towards organic hydroperoxides
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additional information
?
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Mus musculus BALB/c
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infection of skeletal muscle with Trichinella spiralis affects the Km of the enzyme due to alterations of the enzyme's quarternary structure, overview
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additional information
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Serratia marcescens CIP 6755, Enterobacter cloacae CIP 6085, Proteus vulgaris ATCC8427
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bacterial enzyme represents a defence against the effects of antibiotics
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NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate)
LITERATURE
(Substrate)
COMMENTARY
(Product)
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
?
show the reaction diagram
Q93113
detoxification of the insecticide DDT, especially by isozyme agGSTe2
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-
?
12-oxo-phytodienoic acid + glutathione
10-S-glutathionyl-12-oxo-phytodienoic acid + H2O
show the reaction diagram
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
show the reaction diagram
-
HCCA isomerase catalyzes the glutathione-dependent interconversion of 2-hydroxychromene-2-carboxylic acid and trans-o-hydroxybenzylidene pyruvic acid in the naphthalene catabolic pathway of Pseudomonas putida, mechanisms in the naphthalene catabolic pathwayoverview
-
?
brostallicin + glutathione
glutathionyl-brostallicin
show the reaction diagram
-
involved in activation of the prodrug, mechanism, overview. The reaction proceeds via the alpha-chloroamido derivative of the GSH-brostallicin adduct, is able to alkylate DNA in a sequence-specific manner and appears to be the active form of the drug, brostallicin cytotoxicity of brostallicin is higher in cells overexpressing either the GST-pi or the GST-mu gene
-
?
glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
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-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
-
-
-
?
glutathione + (2Z,4E)-3-chloro-6-(3,5-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
?
show the reaction diagram
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-
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-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
the catalytic activity of purified GST from Nanyang city population with GSH is much higher than the activity of the enzyme from other populations, while the Wuzhou population reaches the highest in Vmax for substrate 1-chloro-2,4-dinitrobenzene
-
?
glutathione + alachlor
?
show the reaction diagram
-
isozyme GSTI
-
-
?
glutathione + hematin
?
show the reaction diagram
Q6J1M5
GST-1 is involved in parasite heme detoxification during hemoglobin digestion or heme uptake
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-
?
glutathione + microcystin-LR
?
show the reaction diagram
-
cyanobacterial toxins are hypothesized to contribute to the mortality of prawns, many aquatic organisms have the possibility of detoxifying cyanobacterial toxins, e.g. nodularin or microcystin-LR, via conjugation to glutathione
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-
?
glutathione + nodularin
?