Information on EC 2.5.1.18 - glutathione transferase

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The expected taxonomic range for this enzyme is: Eukaryota, Bacteria, Archaea

EC NUMBER
COMMENTARY hide
2.5.1.18
-
RECOMMENDED NAME
GeneOntology No.
glutathione transferase
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
RX + glutathione = HX + R-S-glutathione
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
aryl group transfer
PATHWAY
BRENDA Link
KEGG Link
MetaCyc Link
4-hydroxy-2-nonenal detoxification
-
-
Drug metabolism - cytochrome P450
-
-
gliotoxin biosynthesis
-
-
glutathione metabolism
-
-
Glutathione metabolism
-
-
glutathione-mediated detoxification I
-
-
glutathione-mediated detoxification II
-
-
Metabolism of xenobiotics by cytochrome P450
-
-
SYSTEMATIC NAME
IUBMB Comments
RX:glutathione R-transferase
A group of enzymes of broad specificity. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group. Also catalyses the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrile, certain isomerization reactions and disulfide interchange.
CAS REGISTRY NUMBER
COMMENTARY hide
50812-37-8
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
alpha, mu and pi class isozymes
-
-
Manually annotated by BRENDA team
PMD and PMD-R strains, the latter is a highly resistant strain, Isla Mujeres (IM) strain, New Orleans (NO) susceptible strain, isozymes GSTE1-GSTE8
-
-
Manually annotated by BRENDA team
gene Atu3701 encoding an eta class GST, i.e. AtuGSTH1-1
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-
Manually annotated by BRENDA team
gene Atu3701 encoding an eta class GST, i.e. AtuGSTH1-1
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Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
different subspecies e.g. ligustica, anatolia, and caucasia
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-
Manually annotated by BRENDA team
isoenzyme I; isoenzyme II
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-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain SUD-S and GER-01
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-
Manually annotated by BRENDA team
strain SUD-S and GER-01
-
-
Manually annotated by BRENDA team
isozymes GST2 and GST3
-
-
Manually annotated by BRENDA team
Burkholderia xenovorans
strain LB400, gene bphK
-
-
Manually annotated by BRENDA team
beagle dogs
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
a cold-adapted marine bivalve Iceandic scallop, mu-class enzyme
SwissProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
pumpkin
-
-
Manually annotated by BRENDA team
Straus 1820
-
-
Manually annotated by BRENDA team
isozymes GSTD1 and GSTD10
-
-
Manually annotated by BRENDA team
CIP 6085
-
-
Manually annotated by BRENDA team
CIP 6085
-
-
Manually annotated by BRENDA team
strain TG2
Uniprot
Manually annotated by BRENDA team
from an indian isolate of buffalo liver origin
-
-
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
two omega GST genes, HdGSTO1 and HdGSTO2
-
-
Manually annotated by BRENDA team
rubber tree, 5 forms
-
-
Manually annotated by BRENDA team
sigma class isozyme, gene gst; fall webworm, gene gst, sigma class isozyme
SwissProt
Manually annotated by BRENDA team
Ilex sp.
squid
-
-
Manually annotated by BRENDA team
AF101 and CIP 666
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Antarctic soft-shelled clam
-
-
Manually annotated by BRENDA team
three field populations collected from Nanyang city of Henan Province, and Wuzhou and Hezhou cities of Guangxi Province, China
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-
Manually annotated by BRENDA team
japanese monkey
-
-
Manually annotated by BRENDA team
rhesus monkey
-
-
Manually annotated by BRENDA team
cabbage moth
-
-
Manually annotated by BRENDA team
cytosolic enzymes, referred to as alpha, mu, pi and theta, and microsomal enzyme
-
-
Manually annotated by BRENDA team
alfalfa
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
striped bass
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
-
-
Manually annotated by BRENDA team
CD1 mice
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-
Manually annotated by BRENDA team
two epsilon-class GSTs MdGST6A and MdGST6B
UniProt
Manually annotated by BRENDA team
Myathropa florea
-
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
genes Na-gst-1, Na-gst-2, and Na-gst-3 encoding isozymes GST-1, GST-2, and GST-3
UniProt
Manually annotated by BRENDA team
coho salmon, several isozymes, e.g. pi and rho-class GSTs, as well as alpha and mu class isozymes
SwissProt
Manually annotated by BRENDA team
rainbow trout
-
-
Manually annotated by BRENDA team
isozymes of pi, phi, mu, and alpha class
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-
Manually annotated by BRENDA team
enzyme form GSTR1
SwissProt
Manually annotated by BRENDA team
isozymes of classes mu, pi, theta, alpha, and tau
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-
Manually annotated by BRENDA team
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-
-
Manually annotated by BRENDA team
runner bean
-
-
Manually annotated by BRENDA team
theta class isozyme, GSTT1, gene gstt1
SwissProt
Manually annotated by BRENDA team
pea
-
-
Manually annotated by BRENDA team
AF 2924
-
-
Manually annotated by BRENDA team
ATCC8427
-
-
Manually annotated by BRENDA team
ATCC8427
-
-
Manually annotated by BRENDA team
ATCC 27853
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-
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
Rattus norvegicus Sprague-Dawley
-
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-
Manually annotated by BRENDA team
-
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-
Manually annotated by BRENDA team
the single-site mutation A122C and N124A/V (but not N124S/Y/C) restores the GST activity of Ure2p protein toward 1-chloro-2,4-dinitrobenzene, while causing a substantial reduction in glutathione peroxidase activity
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-
Manually annotated by BRENDA team
ssGST3
SwissProt
Manually annotated by BRENDA team
CIP 6755
-
-
Manually annotated by BRENDA team
CIP 6755
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-
Manually annotated by BRENDA team
giant foxtail, grass weed
-
-
Manually annotated by BRENDA team
six glutathione S-transferase-like genes, sogst1-sogst6
-
-
Manually annotated by BRENDA team
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-
Manually annotated by BRENDA team
common cutworm
-
-
Manually annotated by BRENDA team
Sus scrofa Yorkshire pig
gene GSTA1
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
white clover
-
-
Manually annotated by BRENDA team
cultivar Gamay Freaux variant Teinturier
UniProt
Manually annotated by BRENDA team
porina moth
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
evolution
malfunction
metabolism
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid + glutathione
2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid + HBr
show the reaction diagram
-
-
-
-
?
(13S,9Z,11E)-13-hydroperoxyoctadeca-9,11-dienoic acid + GSH
?
show the reaction diagram
(15S,5Z,8Z,10E,14Z)-15-hydroperoxyeicosa-5,8,10,14-tetraenoic acid + GSH
?
show the reaction diagram
(2,3-dichloro-4-[2-methylenebutyryl]phenoxy)acetic acid + glutathione
?
show the reaction diagram
-
i.e. ethacrynic acid
-
-
?
(5S,6E,8Z,11Z,14Z)-5-hydroperoxyeicosa-6,8,11,14-tetraenoic acid + GSH
?
show the reaction diagram
(9S,10E,12E)-9-hydroperoxyoctadeca-10,12-dienoic acid + GSH
?
show the reaction diagram
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
1,1-dichloro-2,2-bis-(4-chlorophenyl)ethylene + ?
show the reaction diagram
i.e. DDT, modeling of DDT into the putative DDT-binding pocket, catalytic mechanism of isozyme agGSTe2 that shows high activity through the inclination of the upper part of H4 helix, H4'' helix, which brings residues Arg112, Glu116, and Phe120 closer to the GSH-binding site resulting in a more efficient GS- stabilizing hydrogen-bond-network and higher DDT-binding affinity, overview
product formation through an elimination reaction triggered by the nucleophilic attack of the thiolate group of GS- on the beta-hydrogen of DDT
-
?
1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + glutathione
?
show the reaction diagram
detoxification of the insecticide DDT, especially by isozyme agGSTe2
-
-
?
1,2-dichloro-4-nitrobenzene + glutathione
S-(2-chloro-4-nitro-phenyl)glutathione + HCl
show the reaction diagram
binding structure with wild-type and mutant Y119E and F123A enzymes, overview
-
-
?
1,2-dichloro-4-nitrobenzene + GSH
?
show the reaction diagram
1,2-epoxy-3-(4-nitrophenoxy)-propane + glutathione
?
show the reaction diagram
1,2-epoxy-3-(p-nitrophenoxy)propane + glutathione
?
show the reaction diagram
-
-
-
-
?
1,2-epoxy-3-(p-nitrophenoxy)propane + GSH
?
show the reaction diagram
-
-
-
-
?
1,3,5-triacryloyl-1,3,5-triazinane + glutathione
L-gamma-glutamyl-S-[3-(3,5-diacryloyl-1,3,5-triazinan-1-yl)-3-oxopropyl]-L-cysteinylglycine
show the reaction diagram
-
-
-
-
?
1,3,5-trinitrobenzene + glutathione
S-(2,4,6-trinitrocyclohexa-2,5-dien-1-yl)glutathione
show the reaction diagram
an anionic sigma-complex is formed between GSH and 1,3,5-trinitrobenzene and is stabilized by Arg15. The trinitrocyclohexadienate moiety of the sigma-complex binds the H-site where the catalytic residue, Tyr9, was identified to hydrogen bond to an o-nitro group of the sigma-complex
-
-
?
1,3-bis-(2-chloroethyl)-1-nitrosourea + glutathione
?
show the reaction diagram
1-bromo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HBr
show the reaction diagram
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
?
show the reaction diagram
-
-
-
-
?
1-chloro-2,3-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
1-chloro-2,3-dinitrobenzene + GSH
?
show the reaction diagram
1-chloro-2,3-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
1-chloro-2,4-dinitrobenzene + glutathione
2,4-dinitrobenzyl-glutathione + HCl
show the reaction diagram
1-chloro-2,4-dinitrobenzene + glutathione
chloride + L-gamma-glutamyl-S-(2,4-dinitrophenyl)-L-cysteinylglycine
show the reaction diagram
-
-
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,3-dinitrophenyl)-glutathione + HCl
show the reaction diagram
Tyr119 not only plays a role in hydrophobic substrate binding but also in packing of the active site pocket, which influences chemical interactions involved in enzyme catalysis
-
-
?
1-chloro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
1-chloro-2,4-dinitrobenzene + GSH
1-glutathionyl-2,3-dinitrobenzene + HCl
show the reaction diagram
1-chloro-2,4-dinitrobenzene + GSH
?
show the reaction diagram
1-chloro-2,4-dinitrobenzene + GSH
S-(2,3-dinitrophenyl)glutathione + HCl
show the reaction diagram
1-chloro-2,4-dinitrobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
1-fluoro-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HF
show the reaction diagram
1-iodo-2,4-dinitrobenzene + glutathione
S-(2,4-dinitrophenyl)glutathione + HI
show the reaction diagram
-
-
-
-
?
1-methyl-4-nitro-5-[(4-nitrophenyl)thio]-1H-imidazole + glutathione
?
show the reaction diagram
-
-
-
-
?
12-oxo-phytodienoic acid + glutathione
10-S-glutathionyl-12-oxo-phytodienoic acid + H2O
show the reaction diagram
-
-
-
-
?
2,3-hexadienal + GSH
?
show the reaction diagram
-
at 7.5% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
2,4-dinitro-1-iodobenzene + GSH
S-(2,4-dinitrophenyl)glutathione + HI
show the reaction diagram
2-chloro-5-nitropyridine + glutathione
chloride + L-gamma-glutamyl-S-(5-nitropyridin-2-yl)-L-cysteinylglycine
show the reaction diagram
-
-
-
-
?
2-hydroxychromene-2-carboxylic acid
trans-o-hydroxybenzylidene pyruvic acid
show the reaction diagram
2-hydroxyethyl disulfide + glutathione
?
show the reaction diagram
3,4-dichloronitrobenzene + glutathione
?
show the reaction diagram
-
-
-
?
4-chloro-7-nitrobenzofurazan + glutathione
?
show the reaction diagram
-
-
-
-
?
4-hydroxy-2-nonenal + GSH
?
show the reaction diagram
4-hydroxynonenal + glutathione
?
show the reaction diagram
-
-
-
?
4-hydroxynonenal + GSH
?
show the reaction diagram
4-nitrobenzyl chloride + glutathione
?
show the reaction diagram
4-nitrobenzyl chloride + glutathione
S-(4-nitrobenzyl)glutathione + HCl
show the reaction diagram
-
-
-
?
4-nitrobenzyl chloride + glutathione
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
4-nitrophenethyl bromide + glutathione
?
show the reaction diagram
4-nitrophenethyl bromide + glutathione
S-(4-nitrophenyl)glutathione + HBr
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + glutathione
?
show the reaction diagram
-
-
-
?
4-nitrophenyl acetate + GSH
?
show the reaction diagram
4-nitrophenyl butyrate + glutathione
S-(4-nitrophenyl)glutathione + butyrate
show the reaction diagram
-
-
-
?
4-nitrophenylacetate + glutathione
?
show the reaction diagram
-
-
-
-
?
4-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
5-androstene-3,17-dione + glutathione
?
show the reaction diagram
5-pregnene-3,20-dione + glutathione
?
show the reaction diagram
5-[[(3,4-dinitrophenyl)carbonyl]amino]-2-(6-hydroxy-3-oxo-3H-xanthen-9-yl)benzoic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + glutathione
?
show the reaction diagram
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
7-chloro-4-glutathionylbenzo-2-oxa-1,3-diazole
show the reaction diagram
-
-
-
-
?
7-chloro-4-nitrobenzo-2-oxa-1,3-diazole + GSH
?
show the reaction diagram
7-oxabicyclo[4.1.0]heptan-2-one + glutathione
chloride + L-gamma-glutamyl-S-(6-oxocyclohex-1-en-1-yl)-L-cysteinylglycine
show the reaction diagram
-
-
-
-
?
alachlor + glutathione
?
show the reaction diagram
-
-
-
-
?
allyl isothiocyanate + glutathione
?
show the reaction diagram
aminochrome + glutathione
?
show the reaction diagram
-
-
-
-
?
androstenedione + glutathione
?
show the reaction diagram
-
-
-
-
?
atrazine + glutathione
?
show the reaction diagram
-
-
-
-
?
atrazine + glutathione
atrazine-S-glutathione + HCl
show the reaction diagram
-
-
-
-
?
azathioprine + glutathione
?
show the reaction diagram
-
aromatic substitution. Wild-type hGST M2-2 has modest activity with azathioprine, but mutant C87A/C115A/C174A/M212C displays no detectable activity. The azathioprine activity of wild-type hGST M2-2 can be enhanced 30fold by two point mutations of other residues in the active site
-
-
?
benzyl isothiocyanate + glutathione
?
show the reaction diagram
bromosulfophthalein + glutathione
?
show the reaction diagram
-
-
-
-
?
bromosulfophthalein + GSH
?
show the reaction diagram
brostallicin + glutathione
glutathionyl-brostallicin
show the reaction diagram
butyl nitrite + glutathione
?
show the reaction diagram
-
-
-
-
?
chlorofluoroacetic acid + glutathione
?
show the reaction diagram
-
-
-
-
?
cumene hydroperoxide + glutathione
?
show the reaction diagram
cumene hydroperoxide + GSH
?
show the reaction diagram
dehydroascorbate + glutathione
?
show the reaction diagram
-
-
-
-
?
dehydroascorbic acid + glutathione
?
show the reaction diagram
-
-
-
?
DELTA5-androstene-3,17-dione + glutathione
?
show the reaction diagram
dichloroacetic acid + glutathione
?
show the reaction diagram
ethacrynic acid + glutathione
?
show the reaction diagram
ethacrynic acid + GSH
?
show the reaction diagram
fluazifop-p-butyl + glutathione
?
show the reaction diagram
-
-
-
-
?
fluorodifen + glutathione
?
show the reaction diagram
-
-
-
-
?
glutathione + (2E,4Z)-5-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 5-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
Burkholderia xenovorans
-
-
-
-
?
glutathione + (2Z,4E)-3-chloro-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
chloride + 3-glutathionyl-2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoic acid
show the reaction diagram
glutathione + (2Z,4E)-3-chloro-6-(3,5-dichlorophenyl)-2-hydroxy-6-oxohexa-2,4-dienoic acid
?
show the reaction diagram
Burkholderia xenovorans
-
-
-
-
?
glutathione + (R)-styrene-7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (R,R)-1-phenylpropylene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (R,R)-trans-stilbene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S)-styrene-7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S,S)-1-phenylpropylene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + (S,S)-trans-stilbene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
glutathione + 1,2-diiodoethane
?
show the reaction diagram
glutathione + 1,2-dinitrobenzene
?
show the reaction diagram
glutathione + 1,2-epoxy-3-(4-nitro-phenoxy)propane
?
show the reaction diagram
-
best substrate for the wild-type GST T1-1 and mutant W234K
-
-
?
glutathione + 1,2-epoxy-3-(4-nitrophenoxy)propane
?
show the reaction diagram
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)-propane
?
show the reaction diagram
-
substrate of the theta class isozyme
-
-
?
glutathione + 1,2-epoxy-3-(p-nitrophenoxy)propane
?
show the reaction diagram
glutathione + 1,4-diiodobutane
?
show the reaction diagram
glutathione + 1,6-diiodohexane
?
show the reaction diagram
glutathione + 1,8-diiodooctane
?
show the reaction diagram
glutathione + 1-bromo-4-nitrobenzene
bromide + 4-nitrophenyl-glutathione
show the reaction diagram
-
recombinant catalytically active monoclonal antibody fragment ScFv2F3
-
-
?
glutathione + 1-chloro-2,4-dinitrobenzene
chloride + 2,4-dinitrophenyl-glutathione
show the reaction diagram
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)-glutathione + HCl
show the reaction diagram
glutathione + 1-chloro-2,4-dinitrobenzene
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
glutathione + 1-fluoro-2,4-dinitrobenzene
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodo-3-phenylpropane
iodide + 3-phenylpropyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodobutane
iodide + butyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodoethane
iodide + ethylglutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodoheptane
iodide + heptyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodohexane
?
show the reaction diagram
glutathione + 1-iodohexane
iodide + hexyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodomethane
iodide + methylglutathione
show the reaction diagram
-
best substrate of GST T1-1 mutant W234R
-
-
?
glutathione + 1-iodooctane
iodide + octyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodopentane
iodide + pentyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-iodopropane
iodide + propyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 1-menaphthyl sulfate
?
show the reaction diagram
-
-
-
-
?
glutathione + 1-methyl-4-nitro-5-(4-nitrophenylthio)-1H-imidazole
?
show the reaction diagram
glutathione + 2,4-hexadienal
?
show the reaction diagram
-
-
-
?
glutathione + 2,5-dinitrophenol
?
show the reaction diagram
-
-
-
-
?
glutathione + 2-hydroxyethyl disulfide
?
show the reaction diagram
isozyme GSTO2, low activity
-
-
?
glutathione + 2-methyl-4-nitrobenzyl alcohol
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dichloro-1-nitrobenzene
?
show the reaction diagram
glutathione + 3,4-dinitrobenzanilide
?
show the reaction diagram
-
-
-
-
?
glutathione + 3,4-dinitrobenzoic acid
?
show the reaction diagram
glutathione + 3-iodopropylbenzene
?
show the reaction diagram
glutathione + 4-chloro-3-nitroacetophenone
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-chloro-3-nitrobenzophenone
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-chloro-7-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
glutathione + 4-fluoro-3-nitrobenzanilide
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-hydroxydecenal
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-hydroxynon-2-enal
?
show the reaction diagram
glutathione + 4-hydroxynonenal
?
show the reaction diagram
glutathione + 4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrobenzyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrobenzyl chloride
chloride + 4-nitrophenyl-glutathione
show the reaction diagram
-
substrate of the alpha class isozyme
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(2,4-dinitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 4-nitrobenzyl chloride
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
glutathione + 4-nitrobenzylchloride
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrophenethyl bromide
?
show the reaction diagram
weak substrate
-
-
?
glutathione + 4-nitrophenethyl bromide
bromide + 4-nitrophenethyl-glutathione
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrophenyl acetate
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitrophenyl acetate
S-(4-nitrophenyl)glutathione + HCl
show the reaction diagram
-
-
-
?
glutathione + 4-nitrophenyl bromide
?
show the reaction diagram
-
-
-
-
?
glutathione + 4-nitropyridine
?
show the reaction diagram
-
-
-
-
?
glutathione + 5-nitrofurfural
?
show the reaction diagram
glutathione + 5-nitrofurfural diacetal
?
show the reaction diagram
glutathione + 7-amino-4-chloromethyl coumarin
?
show the reaction diagram
glutathione + 7-chloro-4-nitrobenz-2-oxa-1,3-diazole
?
show the reaction diagram
-
-
-
-
?
glutathione + 7-chloro-4-nitrobenzo-2-oxa-1,3-diazole
?
show the reaction diagram
glutathione + acetochlor
?
show the reaction diagram
glutathione + acrolein
?
show the reaction diagram
-
-
-
-
?
glutathione + adenine propenal
?
show the reaction diagram
-
-
-
-
?
glutathione + alachlor
?
show the reaction diagram
glutathione + allyl-isothiocyanate
?
show the reaction diagram
glutathione + androst-5-ene-3,17-dione
?
show the reaction diagram
-
-
-
-
?
glutathione + anti-benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide
?
show the reaction diagram
-
-
-
-
?
glutathione + atrazine
?
show the reaction diagram
glutathione + azathioprine
6-mercaptopurine + ?
show the reaction diagram
glutathione + benzo[a]pyrene 4,5-oxide
?
show the reaction diagram
glutathione + benzyl isothiocyanate
?
show the reaction diagram
-
substrate of GSTF9
-
-
?
glutathione + bromosulfophthalein
?
show the reaction diagram
glutathione + bromosulphthalein
?
show the reaction diagram
glutathione + butachlor
?
show the reaction diagram
glutathione + chlorambucil
?
show the reaction diagram
-
-
-
-
?
glutathione + cis-6-(2-acetylvinylthio)purine
?
show the reaction diagram
-
-
-
?
glutathione + cryptophycin 52
?
show the reaction diagram
glutathione + cryptophycin 53
?
show the reaction diagram
glutathione + cumene hydroperoxide
?
show the reaction diagram
glutathione + cyclohexyl-isothiocyanate
?
show the reaction diagram
glutathione + ethacrynic acid
?
show the reaction diagram
glutathione + ethylene diiodide
?
show the reaction diagram
-
-
-
?
glutathione + fenchlorim
?
show the reaction diagram
-
-
-
-
?
glutathione + fenoxaprop
4-hydroxyphenoxypropanoic acid + glutathione conjugate
show the reaction diagram
-
herbicide
-
?
glutathione + fluorodifen
4-nitrophenol + (2-nitro-4-trifluoromethylphenyl)glutathione
show the reaction diagram
-
-
-
-
?
glutathione + fluorodifen
4-nitrophenol + 2-nitro-4-trifluoromethylphenol-glutathione
show the reaction diagram
glutathione + fluorodifen
?
show the reaction diagram
-
substrate of the tau class isozyme
-
-
?
glutathione + H2O2
?
show the reaction diagram
-
-
-
?
glutathione + hematin
?
show the reaction diagram
glutathione + hexa 2,4-dienal
?
show the reaction diagram
-
-
-
-
?
glutathione + hexa-2,4-dienal
?
show the reaction diagram
glutathione + hydroxyethyldisulfide
?
show the reaction diagram
-
-
-
-
?
glutathione + indomethane
?
show the reaction diagram
glutathione + iodomethane
?
show the reaction diagram
glutathione + linoleic acid hydroperoxide
?
show the reaction diagram
glutathione + metolachlor
?
show the reaction diagram
glutathione + microcystin-LR
?
show the reaction diagram
glutathione + naphthalene oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + nitrobutyl chloride
chloride + nitrobutyl-glutathione
show the reaction diagram
-
-
-
?
glutathione + nodularin
?
show the reaction diagram
glutathione + petrilachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + phenethyl-isothiocyanate
?
show the reaction diagram
glutathione + pretilachlor
?
show the reaction diagram
-
-
-
-
?
glutathione + propyl-isothiocyanate
?
show the reaction diagram
glutathione + styrene 7,8-oxide
?
show the reaction diagram
-
-
-
-
?
glutathione + styrene oxide
?
show the reaction diagram
glutathione + sulforaphane
?
show the reaction diagram
glutathione + terbuthylazine
?
show the reaction diagram
glutathione + tert-butyl hydroperoxide
?
show the reaction diagram
glutathione + trans,trans-2,4-decadienal
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-2-nonenal
?
show the reaction diagram
glutathione + trans-4-phenyl-3-buten-2-one
?
show the reaction diagram
glutathione + trans-4-phenyl-3-butene-2-one
?
show the reaction diagram
-
-
-
-
?
glutathione + trans-6-(2-acetylvinylthio)guanine
?
show the reaction diagram
-
-
-
?
glutathione + trans-trans-2,4-decadienal
?
show the reaction diagram
GSH reductase + GSH
?
show the reaction diagram
harderoporphyrinogen + glutathione
harderoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-
-
-
-
?
hydrogen peroxide + glutathione
?
show the reaction diagram
iodobutane + glutathione
?
show the reaction diagram
-
-
-
-
?
iodohexane + glutathione
?
show the reaction diagram
-
-
-
-
?
iodomethane + glutathione
?
show the reaction diagram
-
-
-
-
?
maleylacetone + glutathione
?
show the reaction diagram
-
-
-
-
?
methyl 3-(4-methoxyphenyl)oxirane-2-carboxylate + glutathione
chloride + L-gamma-glutamyl-S-[2-hydroxy-3-methoxy-1-(4-methoxyphenyl)-3-oxopropyl]-L-cysteinylglycine
show the reaction diagram
-
-
-
-
?
metolachlor + glutathione
?
show the reaction diagram
-
-
-
-
?
monochlorobimane + glutathione
bimane-glutathione + HCl
show the reaction diagram
-
-
-
-
?
monochlorobimane + GSH
?
show the reaction diagram
nitrophenyl acetate + GSH
?
show the reaction diagram
-
6.5% of the activity with 1-chloro-2,3-dinitrobenzene
-
-
?
nonenal + glutathione
?
show the reaction diagram
-
-
-
-
?
phenethyl isothiocyanate + glutathione
?
show the reaction diagram
propyl isothiocyanate + glutathione
?
show the reaction diagram
protoporphyrinogen + glutathione
protoporphyrinogen-S-glutathione + H2O
show the reaction diagram
-
-
-
-
?
rac-4-hydroxynonenal + glutathione
S-(4-hydroxy-1-oxononan-3-yl)glutathione
show the reaction diagram
-
elimination of the lipid peroxidation product 4-hydroxynonenal, a toxic compound that contributes to numerous diseases
-
-
?
rac-4-hydroxynonenal + glutathione
S-[(2S)-3-hydoxy-2-(2-oxoethyl)octyl]glutathione
show the reaction diagram
-
GSTA1-1 isoform has poor catalytic efficiency with 4-hydroxynonenal, GSTA4-4 has negligible stereoselectivity towards the two 4-hydroxynonenal enantiomers, despite its high catalytic chemospecificity for alkenals
product binding, overview
-
?
reduced glutathione + 1,2-dichloro-4-nitrobenzene
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + 1-chloro-2,4-dinitrobenzene
S-2,4-dinitrophenylglutathione + HCl
show the reaction diagram
-
-
-
-
?
reduced glutathione + 4-nitrobenzyl chloride
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + 4-nitrophenethyl bromide
?
show the reaction diagram
-
-
-
-
?
reduced glutathione + ethacrynic acid
?
show the reaction diagram
-
-
-
-
?
RSSR + glutathione
glutathione-SSR + R-SH
show the reaction diagram
RX + glutathione
HX + R-S-G
show the reaction diagram
RX + glutathione
HX + R-S-glutathione
show the reaction diagram
-
-
-
-
?
styrene oxide + glutathione
?
show the reaction diagram
tertiary butyl hydroperoxide + glutathione
?
show the reaction diagram
trans-2-nonenal + glutathione
?
show the reaction diagram
trans-2-nonenal + GSH
?
show the reaction diagram
-
at 1% of the activity with 1-chloro-2,4-dinitrobenzene
-
-
?
trans-4-phenyl-3-buten-2-one + glutathione
?
show the reaction diagram
-
-
-
-
?
trans-phenyl-butenone + GSH
?
show the reaction diagram
[(methylamino)[methyl(nitroso)amino]methyl]cyanamide + glutathione
[bis(methylamino)methyl]cyanamide + S-nitrosoglutathione
show the reaction diagram
-
transnitrosylation
-
-
?
[3-(4-nitrophenyl)oxiran-2-yl]methanol + glutathione
?
show the reaction diagram
-
-
-
-
?
additional information
?
-