Protein Variants | Comment | Organism |
---|---|---|
C16A | mutation causes a high increase in the KM-value. Mutation diminishes activity with both chlorofluoroacetic acid and maleylacetone but shows significantly elevated activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid as a substrate. This elevated activity appears to be driven by a high turnover number. The diminished activity with maleylacetone results from a low turnover number | Homo sapiens |
R175A | mutation results in a significant lowering of the turnover number for (+)-2-bromo-3-(4-nitrophenyl)propanoic acid and maleylacetone, elevated KM-value for maleylacetone | Homo sapiens |
R175K | mutation results in a significant lowering of the turnover number for (+)-2-bromo-3-(4-nitrophenyl)propanoic acid and maleylacetone | Homo sapiens |
S14A | inactive mutant enzyme | Homo sapiens |
S15A | mutant enzyme shows low isomerase activity with maleylacetone as a substrate (about 15% of wild-type) and low activity with chlorofluoroacetic acid, it shows elevated activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid as the substrate | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0139 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.0146 | - |
GSH | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.0178 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.023 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.025 | - |
GSH | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.027 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.029 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1d-1d | Homo sapiens | |
0.044 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.047 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
0.064 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
0.064 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.068 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.096 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1b-1b | Homo sapiens | |
0.117 | - |
GSH | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
0.128 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1a-1a | Homo sapiens | |
0.134 | - |
GSH | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
0.223 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.287 | - |
GSH | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
0.298 | - |
GSH | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.319 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.347 | - |
maleylacetone | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.417 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.768 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
spectrophotometric assay with 2-bromo-3-(4-nitrophenyl)propionic acid as substrate | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid + glutathione | - |
Homo sapiens | 2-(glutathion-S-yl)-3-(4-nitrophenyl)propanoic acid + HBr | - |
? | |
chlorofluoroacetic acid + glutathione | - |
Homo sapiens | ? | - |
? | |
dichloroacetic acid + glutathione | - |
Homo sapiens | ? | - |
? | |
maleylacetone + glutathione | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme plays an important role in the metabolism of tyrosine via its maleylacetoacetate isomerase activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
glutathione transferase zeta | - |
Homo sapiens |
glutathione transferase Zeta 1-1 | variants glutathione transferase Zeta 1a-1a, glutathione transferase Zeta 1b-1b, glutathione transferase Zeta 1c-1c, glutathione transferase Zeta 1d-1d | Homo sapiens |
hGSTZ1-1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.19 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.19 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.347 | - |
maleylacetone | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.55 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1d-1d | Homo sapiens | |
0.59 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.61 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c | Homo sapiens | |
0.61 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
0.82 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1b-1b | Homo sapiens | |
1 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
1 | - |
GSH | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
2.55 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
2.55 | - |
GSH | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c, reaction with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens | |
13 | - |
(+)-2-bromo-3-(4-nitrophenyl)propanoic acid | pH 7.4, 37°C, enzyme variant glutathione transferase Zeta 1a-1a | Homo sapiens | |
72.6 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
72.6 | - |
GSH | pH 7.4, 37°C, mutant enzyme S15A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
141 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
141 | - |
GSH | pH 7.4, 37°C, mutant enzyme C16A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
149 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c | Homo sapiens | |
149 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175A of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
368 | - |
maleylacetone | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c | Homo sapiens | |
368 | - |
GSH | pH 7.4, 37°C, mutant enzyme R175K of glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens | |
464 | - |
maleylacetone | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c | Homo sapiens | |
464 | - |
GSH | pH 7.4, 37°C, glutathione transferase Zeta 1c-1c, reaction with maleylacetone | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
10 | - |
activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6.5 | 11 | pH 6.5: about 65% of maximal activity, pH 11: about 85% of maximal activity, activity with (+)-2-bromo-3-(4-nitrophenyl)propanoic acid | Homo sapiens |