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Literature summary for 2.5.1.18 extracted from
- Purification and some properties of glutathione-S-epoxide transferase from guinea pig liver (1977), J. Biochem., 82, 407-415.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| epichlorohydrin | 3 mM, competitive | Cavia porcellus |  |
| guanidine hydrochloride | denaturation at 6 M | Cavia porcellus | |
| naphthalene oxide | 0.09 mM, competitive | Cavia porcellus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Cavia porcellus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
2 * 25000, SDS-PAGE | Cavia porcellus |
| 45000 | 47000 | sedimentation equilibrium analysis, gel filtration | Cavia porcellus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Cavia porcellus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Cavia porcellus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Cavia porcellus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
- |
Cavia porcellus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 4-nitrobenzyl chloride | - |
Cavia porcellus | ? | - |
? | |
| glutathione + indomethane | - |
Cavia porcellus | ? | - |
? | |
| glutathione + naphthalene oxide | - |
Cavia porcellus | ? | - |
? | |
| glutathione + styrene oxide | - |
Cavia porcellus | ? | - |
? | |
| RX + glutathione | RX: R: aliphatic, aromatic or heterocyclic, X: sulfate, nitrite or halide, enzyme also catalyzes: the addition of aliphatic epoxides and arene oxides to glutathione, the reduction of polyol nitrate by glutathione to polyol and nitrite, certain isomerization reactions and disulfide interchange | Cavia porcellus | HX + R-S-glutathione | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 25000, SDS-PAGE | Cavia porcellus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.037 | - |
naphthalene oxide | - |
Cavia porcellus | |
| 1.49 | - |
epichlorohydrin | - |
Cavia porcellus | |
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