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Literature summary for 2.5.1.18 extracted from
- Glutathione transferases from parasites: a biochemical view (2008), Acta Trop., 105, 99-112.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Ascaris suum |  |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Clonorchis sinensis | |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Onchocerca volvulus | |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Plasmodium falciparum | |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Schistosoma japonicum | |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Schistosoma mansoni | |
| 1-Amino-4-{[4-({4-chloro-6-[(2-sulfophenyl)amino]-1,3,5-triazin-2-yl}amino)-3-sulfophenyl]amino}-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid | - |
Taenia solium | |
| albendazole | - |
Ascaris suum | |
| albendazole | - |
Clonorchis sinensis | |
| albendazole | - |
Schistosoma japonicum | |
| albendazole | - |
Schistosoma mansoni | |
| bilirubin | - |
Ascaris suum | |
| bilirubin | - |
Schistosoma japonicum | |
| bilirubin | - |
Schistosoma mansoni | |
| bithionol | - |
Ascaris suum | |
| bithionol | - |
Schistosoma japonicum | |
| bithionol | - |
Schistosoma mansoni | |
| Bromosulphthalein | - |
Ascaris suum | |
| Bromosulphthalein | - |
Clonorchis sinensis | |
| Bromosulphthalein | - |
Onchocerca volvulus | |
| Bromosulphthalein | - |
Schistosoma japonicum | |
| Bromosulphthalein | - |
Schistosoma mansoni | |
| Bromosulphthalein | - |
Taenia solium | |
| haematin | - |
Ancylostoma caninum | |
| haematin | - |
Onchocerca volvulus | |
| haematin | - |
Plasmodium falciparum | |
| haematin | - |
Schistosoma japonicum | |
| haematin | - |
Schistosoma mansoni | |
| Hexachlorophene | - |
Ascaris suum | |
| Hexachlorophene | - |
Schistosoma japonicum | |
| Hexachlorophene | - |
Schistosoma mansoni | |
| protoporphyrin IX | - |
Ascaris suum | |
| protoporphyrin IX | - |
Plasmodium falciparum | |
| protoporphyrin IX | - |
Schistosoma japonicum | |
| protoporphyrin IX | - |
Schistosoma mansoni | |
| Triphenyltin chloride | - |
Ascaris suum | |
| Triphenyltin chloride | - |
Clonorchis sinensis | |
| Triphenyltin chloride | - |
Onchocerca volvulus | |
| Triphenyltin chloride | - |
Schistosoma japonicum | |
| Triphenyltin chloride | - |
Schistosoma mansoni | |
| Triphenyltin chloride | - |
Taenia solium | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.15 | - |
1-chloro-2,4-dinitrobenzene | - |
Clonorchis sinensis | |
| 0.16 | - |
glutathione | - |
Plasmodium falciparum | |
| 0.2 | - |
glutathione | - |
Plasmodium yoelii | |
| 0.37 | - |
glutathione | - |
Schistosoma mansoni | |
| 0.43 | - |
glutathione | - |
Schistosoma japonicum | |
| 0.9 | - |
glutathione | - |
Taenia solium | |
| 1.28 | - |
1-chloro-2,4-dinitrobenzene | - |
Wuchereria bancrofti | |
| 2 | - |
1-chloro-2,4-dinitrobenzene | - |
Taenia solium | |
| 2 | - |
1-chloro-2,4-dinitrobenzene | Km above 2.0 mM | Plasmodium falciparum | |
| 2.67 | - |
1-chloro-2,4-dinitrobenzene | - |
Ascaris suum | |
| 2.68 | - |
1-chloro-2,4-dinitrobenzene | - |
Schistosoma japonicum | |
| 2.71 | - |
1-chloro-2,4-dinitrobenzene | - |
Onchocerca volvulus | |
| 3.3 | - |
1-chloro-2,4-dinitrobenzene | - |
Plasmodium yoelii | |
| 3.36 | - |
1-chloro-2,4-dinitrobenzene | - |
Schistosoma mansoni | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | - |
Ascaris suum | 5829 | - |
| cytosol | - |
Schistosoma japonicum | 5829 | - |
| cytosol | - |
Plasmodium falciparum | 5829 | - |
| cytosol | - |
Plasmodium yoelii | 5829 | - |
| cytosol | - |
Rattus norvegicus | 5829 | - |
| cytosol | - |
Mus musculus | 5829 | - |
| cytosol | - |
Sus scrofa | 5829 | - |
| cytosol | - |
Fasciola hepatica | 5829 | - |
| cytosol | - |
Schistosoma mansoni | 5829 | - |
| cytosol | - |
Onchocerca volvulus | 5829 | - |
| cytosol | - |
Wuchereria bancrofti | 5829 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 22000 | - |
2 * 22000 | Plasmodium yoelii |
| 25000 | - |
2 * 25000 | Plasmodium falciparum |
| 25100 | - |
2 * 25100, gel filtration | Clonorchis sinensis |
| 26000 | - |
2 * 26000, gel filtration | Schistosoma mansoni |
| 26200 | - |
2 * 26200 | Schistosoma japonicum |
| 26500 | - |
2 * 26500, gel filtration | Taenia solium |
| 30000 | - |
2 * 30000 | Ancylostoma caninum |
| 36000 | - |
2 * 36000 | Onchocerca volvulus |
| 58500 | - |
- |
Schistosoma japonicum |
| 60000 | - |
SDS-PAGE | Taenia solium |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Ancylostoma caninum | Q6J1M5 | - |
- |
| Ascaris suum | P46436 | - |
- |
| Clonorchis sinensis | Q1L2C7 | - |
- |
| Echinococcus granulosus | O16058 | - |
- |
| Fasciola hepatica | P56598 | - |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | P24472 | - |
- |
| Onchocerca volvulus | P46427 | - |
- |
| Plasmodium falciparum | Q8MU52 | - |
- |
| Plasmodium yoelii | Q7REH6 | - |
- |
| Rattus norvegicus | P04905 | - |
- |
| Schistosoma japonicum | P26624 | - |
- |
| Schistosoma mansoni | P15964 | - |
- |
| Sus scrofa | P80031 | - |
- |
| Taenia solium | Q3ZJN3 | fragment | - |
| Wuchereria bancrofti | Q86LL8 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-dichloro-4-nitrobenzene | - |
Taenia solium | ? | - |
? | |
| glutathione + 1,2-dichloro-4-nitrobenzene | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Ancylostoma caninum | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Ascaris suum | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Schistosoma japonicum | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Plasmodium falciparum | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Plasmodium yoelii | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Taenia solium | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Schistosoma mansoni | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Onchocerca volvulus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Wuchereria bancrofti | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | best substrate | Fasciola hepatica | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | best substrate | Clonorchis sinensis | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 4-hydroxynon-2-enal | - |
Ascaris suum | ? | - |
? | |
| glutathione + 4-hydroxynon-2-enal | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + 4-hydroxynon-2-enal | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + 4-hydroxynon-2-enal | - |
Onchocerca volvulus | ? | - |
? | |
| glutathione + bromosulphthalein | - |
Taenia solium | ? | - |
? | |
| glutathione + bromosulphthalein | - |
Clonorchis sinensis | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Ascaris suum | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Taenia solium | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Onchocerca volvulus | ? | - |
? | |
| glutathione + cumene hydroperoxide | - |
Wuchereria bancrofti | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Ascaris suum | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Plasmodium falciparum | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Taenia solium | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Fasciola hepatica | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Clonorchis sinensis | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + ethacrynic acid | - |
Wuchereria bancrofti | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Ascaris suum | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Taenia solium | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Clonorchis sinensis | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + hexa-2,4-dienal | - |
Onchocerca volvulus | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Ascaris suum | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Taenia solium | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Fasciola hepatica | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Clonorchis sinensis | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Onchocerca volvulus | ? | - |
? | |
| glutathione + trans-2-nonenal | - |
Wuchereria bancrofti | ? | - |
? | |
| glutathione + trans-4-phenyl-3-buten-2-one | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + trans-4-phenyl-3-buten-2-one | - |
Taenia solium | ? | - |
? | |
| glutathione + trans-4-phenyl-3-buten-2-one | - |
Fasciola hepatica | ? | - |
? | |
| glutathione + trans-4-phenyl-3-buten-2-one | - |
Clonorchis sinensis | ? | - |
? | |
| glutathione + trans-4-phenyl-3-buten-2-one | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + trans-trans-2,4-decadienal | - |
Ascaris suum | ? | - |
? | |
| glutathione + trans-trans-2,4-decadienal | - |
Schistosoma japonicum | ? | - |
? | |
| glutathione + trans-trans-2,4-decadienal | - |
Fasciola hepatica | ? | - |
? | |
| glutathione + trans-trans-2,4-decadienal | - |
Schistosoma mansoni | ? | - |
? | |
| glutathione + trans-trans-2,4-decadienal | - |
Onchocerca volvulus | ? | - |
? | |
| additional information | 1,2-dichloro-4-nitrobenzene and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates | Clonorchis sinensis | ? | - |
? | |
| additional information | 1,2-epoxy-3-(4-nitrophenoxy) propane is no substrate | Fasciola hepatica | ? | - |
? | |
| additional information | bromosulphthalein and 1,2-epoxy-3-(4-nitrophenoxy) propane are no substrates | Schistosoma mansoni | ? | - |
? | |
| additional information | no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane | Ascaris suum | ? | - |
? | |
| additional information | no detectable activity with 1,2-dichloro-4-nitrobenzene, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane | Schistosoma japonicum | ? | - |
? | |
| additional information | no detectable activity with 1,2-dichloro-4-nitrobenzene, ethacrynic acid, bromosulphthalein, and 1,2-epoxy-3-(4-nitrophenoxy) propane | Onchocerca volvulus | ? | - |
? | |
| additional information | no detectable activity with 1,2-dichloro-4-nitrobenzene, hexa-2,4-dienal, and bromosulphthalein | Wuchereria bancrofti | ? | - |
? | |
| additional information | no detectable activity with 1,2-epoxy-3-(4-nitrophenoxy) propane | Taenia solium | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | - |
Homo sapiens |
| dimer | - |
Ascaris suum |
| dimer | - |
Rattus norvegicus |
| dimer | - |
Mus musculus |
| dimer | - |
Sus scrofa |
| dimer | - |
Fasciola hepatica |
| dimer | - |
Echinococcus granulosus |
| dimer | - |
Wuchereria bancrofti |
| dimer | 2 * 26000, gel filtration | Schistosoma mansoni |
| homodimer | 2 * 25000 | Plasmodium falciparum |
| homodimer | 2 * 30000 | Ancylostoma caninum |
| homodimer | 2 * 22000 | Plasmodium yoelii |
| homodimer | 2 * 36000 | Onchocerca volvulus |
| homodimer | 2 * 25100, gel filtration | Clonorchis sinensis |
| homodimer | 2 * 26200 | Schistosoma japonicum |
| homodimer | 2 * 26500, gel filtration | Taenia solium |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione S-transferase | - |
Homo sapiens |
| glutathione S-transferase | - |
Ancylostoma caninum |
| glutathione S-transferase | - |
Ascaris suum |
| glutathione S-transferase | - |
Schistosoma japonicum |
| glutathione S-transferase | - |
Plasmodium falciparum |
| glutathione S-transferase | - |
Plasmodium yoelii |
| glutathione S-transferase | - |
Rattus norvegicus |
| glutathione S-transferase | - |
Mus musculus |
| glutathione S-transferase | - |
Sus scrofa |
| glutathione S-transferase | - |
Taenia solium |
| glutathione S-transferase | - |
Fasciola hepatica |
| glutathione S-transferase | - |
Clonorchis sinensis |
| glutathione S-transferase | - |
Schistosoma mansoni |
| glutathione S-transferase | - |
Echinococcus granulosus |
| glutathione S-transferase | - |
Onchocerca volvulus |
| glutathione S-transferase | - |
Wuchereria bancrofti |
| GST | - |
Homo sapiens |
| GST | - |
Ancylostoma caninum |
| GST | - |
Ascaris suum |
| GST | - |
Schistosoma japonicum |
| GST | - |
Plasmodium falciparum |
| GST | - |
Plasmodium yoelii |
| GST | - |
Rattus norvegicus |
| GST | - |
Mus musculus |
| GST | - |
Sus scrofa |
| GST | - |
Taenia solium |
| GST | - |
Fasciola hepatica |
| GST | - |
Clonorchis sinensis |
| GST | - |
Schistosoma mansoni |
| GST | - |
Echinococcus granulosus |
| GST | - |
Onchocerca volvulus |
| GST | - |
Wuchereria bancrofti |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0005 | - |
Cibacron blue 3GA | - |
Plasmodium falciparum | |
| 0.01 | - |
protoporphyrin IX | - |
Plasmodium falciparum | |
| 0.01 | - |
haematin | - |
Plasmodium falciparum | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Schistosoma japonicum | isoelectric focusing | - |
5 |
| Clonorchis sinensis | isoelectric focusing | - |
6.1 |
| Taenia solium | isoelectric focusing | - |
7.1 |
| Schistosoma mansoni | isoelectric focusing | - |
7.4 |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| 0.00003 | - |
- |
Onchocerca volvulus | Cibacron blue 3GA | |
| 0.00005 | - |
- |
Onchocerca volvulus | Triphenyltin chloride | |
| 0.00007 | - |
- |
Clonorchis sinensis | Cibacron blue 3GA | |
| 0.00009 | - |
- |
Ascaris suum | Cibacron blue 3GA | |
| 0.0003 | - |
- |
Ascaris suum | Triphenyltin chloride | |
| 0.00034 | - |
- |
Ascaris suum | Hexachlorophene | |
| 0.00047 | - |
- |
Schistosoma japonicum | Triphenyltin chloride | |
| 0.00055 | - |
- |
Onchocerca volvulus | haematin | |
| 0.00059 | - |
- |
Schistosoma japonicum | Hexachlorophene | |
| 0.00068 | - |
- |
Taenia solium | Bromosulphthalein | |
| 0.00069 | - |
- |
Schistosoma japonicum | Cibacron blue 3GA | |
| 0.00071 | - |
- |
Taenia solium | Cibacron blue 3GA | |
| 0.00075 | - |
- |
Onchocerca volvulus | Bromosulphthalein | |
| 0.001 | - |
- |
Ascaris suum | Bromosulphthalein | |
| 0.00109 | - |
- |
Clonorchis sinensis | Bromosulphthalein | |
| 0.00172 | - |
- |
Clonorchis sinensis | Triphenyltin chloride | |
| 0.00323 | - |
- |
Ancylostoma caninum | haematin | |
| 0.0041 | - |
- |
Schistosoma japonicum | haematin | |
| 0.00632 | - |
- |
Taenia solium | Triphenyltin chloride | |
| 0.0077 | - |
- |
Ascaris suum | bithionol | |
| 0.009 | - |
- |
Ascaris suum | bilirubin | |
| 0.0134 | - |
- |
Schistosoma japonicum | bithionol | |
| 0.0275 | - |
- |
Clonorchis sinensis | albendazole | |
| 0.03 | - |
- |
Ascaris suum | protoporphyrin IX | |
| 0.0364 | - |
- |
Schistosoma japonicum | Bromosulphthalein | |
| 0.116 | - |
- |
Schistosoma japonicum | protoporphyrin IX | |
| 0.25 | - |
- |
Schistosoma japonicum | albendazole | |
| 0.442 | - |
- |
Schistosoma japonicum | bilirubin | |
| 0.52 | - |
- |
Ascaris suum | albendazole | |
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