Literature summary for 2.5.1.18 extracted from

Feng, S.; Zhang, L.; Adilijiang, G.; Liu, J.; Luo, M.; Deng, H.
Substrate profiling of glutathione S-transferase with engineered enzymes and matched glutathione analogues (2014), Angew. Chem. Int. Ed. Engl., 53, 7149-7153.

Search for more literature for 2.5.1.18

Protein Variants

Protein Variants	Comment	Organism
K44A	the mutant shows 95.9% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44A/W40F	the mutant shows 95.2% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44A/W40G	the mutant shows 65.7% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44G	the mutant shows 97% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44G/W40A/R41A	the mutant shows 49.3% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44S	the mutant shows 95.6% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
K44S/W40F/R41A	the mutant shows 66.2% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
R41A	the mutant shows 97.5% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
R41H	the mutant shows 99.55% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
W40A	the mutant shows 89.7% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
W40F	the mutant shows 96.7% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum
W40G	the mutant shows 81.1% binding affinity for GSH compared to the wild type enzyme	Schistosoma japonicum

Organism

Organism	UniProt	Comment	Textmining
Schistosoma japonicum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1-chloro-2,4-dinitrobenzene + glutathione	-	Schistosoma japonicum	S-(2,4-dinitrophenyl)glutathione + HCl	-	?

Synonyms

Synonyms	Comment	Organism
glutathione S-transferase	-	Schistosoma japonicum
GSTM1	-	Schistosoma japonicum

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Release 2023.1 (January 2023)