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Literature summary for 2.5.1.18 extracted from
- The glutathione system of Aspergillus nidulans involves a fungus-specific glutathione S-transferase (2009), J. Biol. Chem., 284, 8042-8053.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| gene gstB, quantitative PCR enzyme expression analysis in wild-type and glrA-deletion DGR1 mutant strain | Aspergillus nidulans |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.032 | - |
glutathione | - |
Aspergillus nidulans |  |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 25000 | - |
2 * 25000, recombinant enzyme, SDS-PAGE | Aspergillus nidulans |
| 51000 | - |
recombinant enzyme, gel filtration | Aspergillus nidulans |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Aspergillus nidulans | - |
- |
- |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0076 | - |
recombinant enzyme, substrate 1-chloro-2,4-dinitrobenzene | Aspergillus nidulans |
| 0.09 | - |
recombint enzyme, substrate cumene hydroperoxide | Aspergillus nidulans |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| cumene hydroperoxide + glutathione | - |
Aspergillus nidulans | ? | - |
? | |
| ethacrynic acid + glutathione | - |
Aspergillus nidulans | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Aspergillus nidulans | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| additional information | 1,2-dichloro-4-nitrobenzene and ethacrynic acid are no substrates | Aspergillus nidulans | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dimer | 2 * 25000, recombinant enzyme, SDS-PAGE | Aspergillus nidulans |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutathione S-transferase | - |
Aspergillus nidulans |
| GST | - |
Aspergillus nidulans |
Expression
| Organism | Comment | Expression |
|---|---|---|
| Aspergillus nidulans | glutathione S-transferase is upregulated 2.6fold in a glutathione reductase depleted glrA-deletion strain, overview | up |
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Release 2023.1 (January 2023)
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