Literature summary for 2.5.1.18 extracted from

Zhao, X.; Fan, Y.; Shen, J.; Wu, Y.; Yin, Z.
Human glutathione S-transferase P1 suppresses MEKK1-mediated apoptosis by regulating MEKK1 kinase activity in HEK293 cells (2006), Mol. Cells, 21, 395-400.

Search for more literature for 2.5.1.18

Cloned(Commentary)

Cloned (Comment)	Organism
co-expression of HA-tagged GST P1 with Flag-tagged DELTAMEKK1 in HEK-293 cells, the overexpression of isozyme GST P1 leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	isozyme GSTP1	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	isozyme GST P1 plays an important role in detoxification and metabolism of xenobiotics, it also regulates the MEKK1-MKK7 signaling pathway, the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview, overexpression of isozyme GST P1 in HEK-293 cells leads to inhibition of both DELTAMEKK1- and etoposide-induced apoptosis, and inhibition of procaspase-3 activation and PARP cleavage, overview	Homo sapiens	?	-	?
additional information	the enzyme inhibits the MEKK1 kinase in vitro and in vivo, overview	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
glutathione S-transferase	-	Homo sapiens

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Release 2023.1 (January 2023)