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Literature summary for 2.5.1.18 extracted from
- Diverging catalytic capacities and selectivity profiles with haloalkane substrates of chimeric alpha class glutathione transferases (2008), Protein Eng. Des. Sel., 21, 329-341.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli XL-1 Blue cells | Homo sapiens |
| expressed in Escherichia coli XL-1 Blue cells | Rattus norvegicus |
| expressed in Escherichia coli XL-1 Blue cells | Bos taurus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q28035 | - |
- |
| Homo sapiens | P08263 | - |
- |
| Homo sapiens | P09210 | - |
- |
| Homo sapiens | Q16772 | - |
- |
| Rattus norvegicus | P04903 | - |
- |
| Rattus norvegicus | P04904 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| Ni-IMAC affinity column chromatography | Homo sapiens |
| Ni-IMAC affinity column chromatography | Rattus norvegicus |
| Ni-IMAC affinity column chromatography | Bos taurus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.004 | - |
using 3-iodopropylbenzene as substrate | Rattus norvegicus |
| 0.019 | - |
using 1,6-diiodohexane as substrate | Rattus norvegicus |
| 0.039 | - |
using 3-iodopropylbenzene as substrate | Homo sapiens |
| 0.066 | - |
using 3-iodopropylbenzene as substrate | Homo sapiens |
| 0.081 | - |
using 1,6-diiodohexane as substrate | Homo sapiens |
| 0.086 | - |
using iodohexane as substrate | Homo sapiens |
| 0.1 | - |
using 3-iodopropylbenzene as substrate | Homo sapiens |
| 0.11 | - |
using 1,6-diiodohexane as substrate | Rattus norvegicus |
| 0.11 | - |
using 3-iodopropylbenzene as substrate | Rattus norvegicus |
| 0.11 | - |
using iodohexane as substrate | Homo sapiens |
| 0.13 | - |
using iodohexane as substrate | Rattus norvegicus |
| 0.21 | - |
using 1,6-diiodohexane as substrate | Homo sapiens |
| 0.24 | - |
using iodohexane as substrate | Bos taurus |
| 0.26 | - |
using iodohexane as substrate | Rattus norvegicus |
| 0.27 | - |
using 1,4-diiodobutane as substrate | Rattus norvegicus |
| 0.27 | - |
using 3-iodopropylbenzene as substrate | Bos taurus |
| 0.38 | - |
using 1,6-diiodohexane as substrate | Bos taurus |
| 0.47 | - |
using 1,4-diiodobutane as substrate | Rattus norvegicus |
| 0.56 | - |
using 1,4-diiodobutane as substrate | Homo sapiens |
| 0.81 | - |
using 1,4-diiodobutane as substrate | Homo sapiens |
| 0.87 | - |
using 1,4-diiodobutane as substrate | Bos taurus |
| 0.91 | - |
using 1,4-diiodobutane as substrate | Homo sapiens |
| 1.03 | - |
using 1,6-diiodohexane as substrate | Homo sapiens |
| 1.38 | - |
using iodohexane as substrate | Homo sapiens |
| 3 | 3.9 | using 1,2-diiodoethane as substrate | Homo sapiens |
| 4.52 | - |
using 1,2-diiodoethane as substrate | Rattus norvegicus |
| 12.8 | - |
using 1,2-diiodoethane as substrate | Rattus norvegicus |
| 26.6 | - |
using 1,2-diiodoethane as substrate | Bos taurus |
| 31.5 | - |
using 1,2-diiodoethane as substrate | Homo sapiens |
| 56.4 | - |
using 1,2-diiodoethane as substrate | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| glutathione + 1,2-diiodoethane | best substrate | Homo sapiens | ? | - |
? |  |
| glutathione + 1,2-diiodoethane | best substrate | Rattus norvegicus | ? | - |
? | |
| glutathione + 1,2-diiodoethane | best substrate | Bos taurus | ? | - |
? | |
| glutathione + 1,4-diiodobutane | - |
Homo sapiens | ? | - |
? | |
| glutathione + 1,4-diiodobutane | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 1,4-diiodobutane | - |
Bos taurus | ? | - |
? | |
| glutathione + 1,6-diiodohexane | - |
Homo sapiens | ? | - |
? | |
| glutathione + 1,6-diiodohexane | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 1,6-diiodohexane | - |
Bos taurus | ? | - |
? | |
| glutathione + 1,8-diiodooctane | - |
Homo sapiens | ? | - |
? | |
| glutathione + 1,8-diiodooctane | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 1,8-diiodooctane | - |
Bos taurus | ? | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Homo sapiens | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Rattus norvegicus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-chloro-2,4-dinitrobenzene | - |
Bos taurus | S-(2,4-dinitrophenyl)glutathione + HCl | - |
? | |
| glutathione + 1-iodohexane | - |
Homo sapiens | ? | - |
? | |
| glutathione + 1-iodohexane | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 1-iodohexane | - |
Bos taurus | ? | - |
? | |
| glutathione + 3-iodopropylbenzene | - |
Homo sapiens | ? | - |
? | |
| glutathione + 3-iodopropylbenzene | - |
Rattus norvegicus | ? | - |
? | |
| glutathione + 3-iodopropylbenzene | - |
Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| alpha class glutathione transferase | - |
Homo sapiens |
| alpha class glutathione transferase | - |
Rattus norvegicus |
| alpha class glutathione transferase | - |
Bos taurus |
| GSTA1-1 | isozyme | Homo sapiens |
| GSTA1-1 | isozyme | Bos taurus |
| GSTA2-2 | isozyme | Homo sapiens |
| GSTA2-2 | isozyme | Rattus norvegicus |
| GSTA3-3 | isozyme | Homo sapiens |
| GSTA3-3 | isozyme | Rattus norvegicus |
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Release 2023.1 (January 2023)
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