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2,4-dinitrophenyl-GARFW-OH + H2O
?
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2,4-dinitrophenyl-GDRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GERFW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFAFW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFDFW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFEFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFFFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFGFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFHFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFIFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFKFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFLFW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFPFW-OH + H2O
?
-
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?
2,4-dinitrophenyl-GFQFW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFRAW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFRDW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFREW-OH + H2O
?
-
-
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?
2,4-dinitrophenyl-GFRFW-OH + H2O
?
-
-
-
?
2,4-dinitrophenyl-GFRGW-OH + H2O
?
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-
-
?
2,4-dinitrophenyl-GFRHW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFRIW-OH + H2O
?
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?
2,4-dinitrophenyl-GFRKW-OH + H2O
?
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?
2,4-dinitrophenyl-GFRLW-OH + H2O
?
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?
2,4-dinitrophenyl-GFRPW-OH + H2O
?
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-
-
?
2,4-dinitrophenyl-GFRQW-OH + H2O
?
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-
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?
2,4-dinitrophenyl-GFRRW-OH + H2O
?
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?
2,4-dinitrophenyl-GFRSW-OH + H2O
?
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-
?
2,4-dinitrophenyl-GFRVW-OH + H2O
?
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-
?
2,4-dinitrophenyl-GFRW R-OH + H2O
?
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-
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-
?
2,4-dinitrophenyl-GFRWA-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWD-OH + H2O
?
-
-
-
-
?
2,4-dinitrophenyl-GFRWE-OH + H2O
?
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-
-
-
?
2,4-dinitrophenyl-GFRWF-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWG-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWI-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWK-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWL-OH + H2O
?
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?
2,4-dinitrophenyl-GFRWP-OH + H2O
?
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-
?
2,4-dinitrophenyl-GFRWQ-OH + H2O
?
-
-
-
?
2,4-dinitrophenyl-GFRWS-OH + H2O
?
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-
-
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?
2,4-dinitrophenyl-GFRWV-OH + H2O
?
-
-
-
?
2,4-dinitrophenyl-GFRWY-OH + H2O
?
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?
2,4-dinitrophenyl-GFRYW-OH + H2O
?
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-
?
2,4-dinitrophenyl-GFSFW-OH + H2O
?
-
-
-
?
2,4-dinitrophenyl-GFVFW-OH + H2O
?
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?
2,4-dinitrophenyl-GFYFW-OH + H2O
?
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?
2,4-dinitrophenyl-GGRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GHRFW-OH + H2O
?
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-
?
2,4-dinitrophenyl-GIRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GKRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GLRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GPRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GQRFW-OH + H2O
?
-
-
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?
2,4-dinitrophenyl-GRRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GSRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GVRFW-OH + H2O
?
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?
2,4-dinitrophenyl-GYRFW-OH + H2O
?
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?
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-(Nepsilon-2,4-dinitrophenyl)Lys + H2O
2-aminobenzoyl-Gly-Ile-Val-Arg + Ala-(Nepsilon-2,4-dinitrophenyl)Lys
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an exoproteolytic substrate
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-
?
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O
?
4-(4-dimethylaminophenylazo)benzoyl-IEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-IEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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no hydrolysis at pH 6.0
-
?
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-D-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-L-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-D-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-L-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-LEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-LEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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no hydrolysis at pH 6.0
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?
4-(4-dimethylaminophenylazo)benzoyl-LRGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-LRGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-RIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RIEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-RIIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RIIEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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no hydrolysis at pH 6.0
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVG-beta-(2-naphthyl)alanine-E-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVG-beta-(2-naphthyl)alanine-E + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFD-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFD + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFL-alpha-aminoadipic acid-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFL-alpha-aminoadipic acid + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
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?
4-(4-dimethylaminophenylazo)benzoyl-RLVGWE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGWE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
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-
-
?
5-amino-1-(phenylsulfonyl)-1H-pyrazol-3-yl thiophene-2-carboxylate + H2O
5-amino-1-(phenylsulfonyl)-1,2-dihydro-3H-pyrazol-3-one + thiophene-2-carbaldehyde
-
-
-
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?
5-amino-1-[(4-methoxyphenyl)sulfonyl]-1H-pyrazol-3-yl pyridine-4-carboxylate + H2O
5-amino-1-[(4-methoxyphenyl)sulfonyl]-1,2-dihydro-3H-pyrazol-3-one + pyridine-4-carbaldehyde
-
-
-
-
?
5-dimethylaminonaphthalene-1-sulfonyl-Phe-Arg-Phe(NO2)-Leu + H2O
?
pH 6.4, 37°C, 2 mM cysteine, 1 mM EDTA
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-
?
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-Ala-camptothecin + H2O
?
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-
major cleavage products are L-Leu-Ala-Leu-Ala-camptothecin, L-Ala-Leu-Ala-camptothecin, L-Leu-Ala-camptothecin, and camptothecin
-
?
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-doxorubicin + H2O
?
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major cleavage products are L-Leu-Ala-Leu-doxorubicin, L-Leu-doxorubicin, and doxorubicin
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?
Abeta peptide + H2O
?
the enzyme cleaves the Abeta peptide from the carboxylic end of Glu11
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-
?
Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp + H2O
Abz-Ala-Phe-Arg + Ser-Ala-X-Gln-EDDnp
kcat/Km for Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp, with X is Asn > Tyr, His, Leu, Trp > Ser, Phe, Pro Lys > Asp, Ala
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-
?
Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp + H2O
Abz-Ala-Phe-Arg + Ser-X-Arg-Ser-Ala-Gln-EDDnp
kcat/Km for Abz-Ala-Phe-Arg-Ser-X-Arg-Ser-Ala-Gln-EDDnp, with X is Asn > Trp, Tyr, Ala > Ser, Phe > His, Lys > Asp, Leu, Pro
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-
?
Abz-Ala-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp + H2O
Abz-Ala-X-Ala-Phe-Arg + Ser-Ala-Gln-EDDnp
kcat/Km for Abz-Ala-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp, with X is Leu, Tyr > Phe, Ala, Ser, Pro > His, Lys > Asn, Asp
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-
?
Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp + H2O
Abz-Ala-X-Arg + Ser-Ala-Ala-Gln-EDDnp
kcat/Km for Abz-Ala-X-Arg-Ser-Ala-Ala-Gln-EDDnp, with X is Phe, Leu > Arg > Ala > Pro
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?
Abz-FF-3-dinitrophenyl-2,3-diaminopropionic acid-W-OH + H2O
?
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-
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?
Abz-FR-3-dinitrophenyl-2,3-diaminopropionic acid-W-OH + H2O
?
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-
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?
Abz-FR-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-P-OH + H2O
?
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-
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?
Abz-FR-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-W-OH + H2O
?
-
-
-
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?
Abz-FRA-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-OH + H2O
?
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-
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?
Abz-FRF(NO2)A + H2O
?
-
-
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?
Abz-FRF-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-OH + H2O
?
-
-
-
-
?
Abz-GIVRAK(Dnp)-OH + H2O
?
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
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-
?
Abz-GIVRAK-Dnp + H2O
?
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-
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?
Abz-GXXRZK(Dnp)-OH + H2O
?
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
-
-
?
Abz-GXXZXK(Dnp)-OH + H2O
?
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
-
-
?
Abz-GXZRXK(Dnp)-OH + H2O
?
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
-
-
?
Abz-GZXRXK(Dnp)-OH + H2O
?
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
-
-
?
Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp + H2O
Abz-X-Ala-Phe-Arg + Ser-Ala-Gln-EDDnp
kcat/Km for Abz-X-Ala-Phe-Arg-Ser-Ala-Gln-EDDnp, with X is Leu, Phe, Trp > Ser, Asn, Asp, Ala > Tyr, His, Lys
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-
?
Ac-Arg-Arg-4-methyl-7-amidocoumarin + H2O
Ac-Arg-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
Ac-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O
?
-
-
-
?
Ac-Arg-Arg-7-amido-4-trifluoromethylcoumarin + H2O
Ac-Arg-Arg + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
Ac-His-Pro-Val-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O
Ac-His-Pro-Val-Lys + 7-amino-3-carbamoyl-4-methylcoumarin
-
assay at pH 5.5, 37°C
-
-
?
acetyl-Arg-Arg-4-methylcoumarin-7-amide + H2O
acetyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O
?
-
a synthetic substrate of caspase-3 and caspase-7
-
-
?
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
acetyl-DEVD + 7-amino-4-methylcoumarin
-
cleavage occurs at pH 4.0, but not at pH 7.5
-
-
?
acetyl-F-R-4-methylcoumarin-7-amide + H2O
acetyl-F-R + 7-amino-4-methylcoumarin
-
-
-
?
acetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
acetyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
alpha-N-benzoyl-DL-Arg-beta-naphthylamide + H2O
alpha-N-benzoyl-DL-Arg + beta-naphthylamine
-
-
-
-
?
amino acid-beta-naphthylamides + H2O
amino acid + beta-naphthylamine
-
-
-
?
amyloid beta peptide + H2O
?
amyloid beta precursor protein + H2O
?
-
cathepsin B selectively cleaves the wild-type beta-secretase site but not the rare Swedish mutant beta-secretase site
-
-
?
amyloid precursor protein C-terminal fragment + H2O
?
-
cathepsin B degraded C-terminal fragments regardless of phosphorylation
-
-
?
amyloid precursor protein intracellular domain + H2O
?
-
-
-
-
?
amyloid-beta + H2O
?
-
-
-
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?
antiprotease secretory leucoprotease inhibitor + H2O
cleaved SLP1 protein
-
i.e. SLP1 protein, cleavage between residues Thr67 and Tyr68
-
?
Arg-4-methylcoumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
-
-
-
?
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
azocasein + H2O
fragments of azocasein
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
benzoyl-L-3-pyridyl-Ala-l-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-3-pyridyl-Ala-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-4-aminocyclohexy-Ala-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminocyclohexyl-Ala-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-4-aminomethyl-N-isopropyl-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminomethyl-N-isopropyl-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-4-aminomethyl-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminomethyl-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-4-guanidine-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-guanidine-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-4-piperidinyl-Ala-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-piperidinyl-Ala-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-Arg-beta-naphthylamide + H2O
benzoyl-L-Arg + beta-naphthylamine
-
-
-
?
benzoyl-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
benzoyl-L-His-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-His-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-N-dimethyl-His-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-N-dimethyl-His-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Phe-Val-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzoyl-Phe-Val-Arg-p-nitroanilide + H2O
benzoyl-Phe-Val-Arg + p-nitroaniline
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
benzyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Ala + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
benzyloxycarbonyl-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
benzyloxycarbonyl-Arg-Arg-4-methyl-7-coumarylamide + H2O
?
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
benzyloxycarbonyl-Arg-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Arg-Arg + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-FR-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-FR + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Gly-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Gly + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-L-leucyl-L-arginine-4-methylcoumaryl-7-amide + H2O
?
-
-
-
?
benzyloxycarbonyl-L-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-L-phenylalaninyl-L-arginine 4-methylcoumaryl-7-amide + H2O
?
-
-
-
?
benzyloxycarbonyl-Lys-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + 4-nitrophenol
benzyloxycarbonyl-Phe-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Phe-Arg + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
benzyloxycarbonyl-Phe-Arg-AMC + H2O
?
-
-
-
?
benzyloxycarbonyl-Phe-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Phe-Arg + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-phenylalanyl-arginine-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, activity at pH 5.0 is 80fold greater than with Arg-Arg
-
-
?
benzyloxycarbonyl-phenylalanyl-arginyl-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
37°C, 1 mM DTT, 1 mM EDTA, pH 6.0
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
beta-lipotropin + H2O
hydrolyzed beta-lipotropin
-
-
-
?
Boc-Asp-Pro-Arg-4-methyl-7-amidocoumarin + H2O
Boc-Asp-Pro-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
Boc-Asp-Pro-Arg-4-methylcoumarin 7-amide + H2O
Boc-Asp-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Boc-L-Leu-L-Lys-L-Arg-4-methylcoumarin-7-amide + H2O
Boc-L-Leu-L-Lys-L-Arg + 7-amino-4-methylcoumarin
-
pH-dependence of reaction
-
?
Boc-Phe-Ser-Arg-7-amido-4-methylcoumarin + H2O
Boc-Phe-Ser-Arg + 7-amino-4-methylcoumarin
29% of the activity compared to benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
-
?
Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin + H2O
Boc-Val-Leu-Lys + 4-methyl-7-aminocoumarin
-
-
-
-
?
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide + H2O
Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Boc-Val-Pro-Arg-7-amido-4-methylcoumarin + H2O
Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin
8% of the activity compared to benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
-
?
BODIPY FL casein + H2O
?
-
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin hydrochloride + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin hydrochloride
-
-
-
-
?
carbobenzoxy-Gly-Gly-Arg-naphthylamide + H2O
? + naphthylamine
-
-
-
?
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
casein + H2O
hydrolyzed casein
caspase 1 precursor + H2O
?
-
-
-
-
?
CBZ-Arg-Arg-4-nitroanilide + H2O
CBZ-Arg-Arg + 4-nitroaniline
-
-
-
?
CBZ-Arg-Arg-7-amido-4-methylcoumarin + H2O
CBZ-Arg-Arg + 7-amino-4-methylcoumarin
-
endopeptidase activity
-
-
?
Cbz-FR-7-amido-4-methylcoumarin + H2O
Cbz-Phe-Arg + 7-amino-4-methylcoumarin
37°C, pH 6.0, 200 mM NaCl, 1 mM EDTA, 5 nM DTT
-
-
?
CBZ-L-Arg-L-Arg-4-nitroanilide + H2O
L-Arg-L-Arg + 4-nitroaniline
-
-
-
?
Cbz-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O
Cbz-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
CBZ-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
-
-
-
?
chemokine (C-C motif) ligand 20 + H2O
CCL20 1-66 isoform + ?
-
CCL20 is also known as liver- and activation-regulated chemokine (LARC), MIP-3alpha, or exodus-1
cathepsin B specifically cleaves off four C-terminally located amino acids and generates a CCL20 1-66 isoform with full functional activity
-
?
Collagen + H2O
Hydrolyzed collagen
D-Pro-Phe-Arg-p-nitroanilide + H2O
D-Pro-Phe-Arg + p-nitroaniline
-
-
-
?
D-Val-Leu-Arg-4-methylcoumarin 7-amide + H2O
D-Val-Leu-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
D-Val-Leu-Lys-p-nitroanilide + H2O
D-Val-Leu-Lys + p-nitroaniline
-
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
Dnp-Gly-Phe-Arg-Trp-X-OH + H2O
Dnp-Gly-Phe + Arg-Trp-X-OH
kcat/Km for Dnp-Gly-Phe-Arg-Trp-X-OH, with X is Phe > Tyr, Ile > Leu > Cval > Arg > Lys, Pro > Gln, Ser > Asp, Glu, Ala
-
-
?
Dnp-Gly-Phe-Arg-X-Trp-OH + H2O
Dnp-Gly-Phe + Arg-X-Trp-OH
kcat/Km for Dnp-Gly-Phe-Arg-X-Trp-OH, with X is Phe > Ser > Leu > Ala > Ile > Tyr, Val > Gln > Lys > Gly > His, Asp > Arg > Glu
-
-
?
Dnp-Gly-Phe-X-Phe-Trp-OH + H2O
Dnp-Gly-Phe-X + Phe-Trp-OH
kcat/Km for Dnp-Gly-Phe-X-Phe-Trp-OH, with X is Arg > Lys > Phe > Leu > Val > His, Gln > Ser > Gly Ala > Glu > Tyr > Ile, Asp
-
-
?
Dnp-Gly-X-Arg-Phe-Trp-OH + H2O
Dnp-Gly-X-Arg + Phe-Trp-OH
kcat/Km for Dnp-Gly-X-Arg-Phe-Trp-OH, with X is Phe > Tyr > Lys > Val > Ala > Ile > Ser, Pro > His > Leu > Arg > Asp, Glu
-
-
?
DQ-collagen IV + H2O
?
-
-
-
-
?
epithelial sodium channel alpha subunit + H2O
?
-
in vitro cleavage studies show that the full-length ENaC alpha subunit fusion protein is cleaved by active cathepsin B but not the full-length beta or gamma subunit fusion proteins
-
-
?
epsilon-aminocaproic acid-L-Leu-Gly-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-Gly + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)serine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)serine + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)threonine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)threonine + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-methyl)-tyrosine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-methyl)-tyrosine + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(S-benzyl)cysteine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(S-benzyl)cysteine + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-Phe-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-Phe + 7-amino-4-methylcoumarin
-
-
-
?
epsilon-aminocaproic acid-L-R-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-R + 7-amino-4-methylcoumarin
-
-
-
?
Fibronectin + H2O
?
-
-
-
?
filaggrin + H2O
hydrolyzed filaggrin
-
-
-
?
gelatin + H2O
hydrolyzed gelatine
-
-
-
?
globin + H2O
partially degraded globin
-
-
-
?
Glucagon + H2O
Hydrolyzed glucagon
-
-
-
?
Gly-Arg-7-amido-4-methylcoumarin + H2O
Gly-Arg + 7-amino-4-methylcoumarin
-
a fluorogenic substrate
-
-
?
Hemoglobin + H2O
Hydrolyzed hemoglobin
-
from goat and from buffalo
-
?
herpes simplex virus type 1 origin binding protein + H2O
herpes simplex virus type 1 origin binding protein 1
53 kDa protein
50 kDa protein
-
?
histones + H2O
hydrolyzed histones
-
-
-
?
human anti-HIV-1 antibody + H2O
?
NbCathB is far more efficient than aleurain-like protease in processing the human anti-HIV-1 antibody 2F5 into fragments
-
-
?
human fibronectin + H2O
?
-
-
-
?
human hemoglobin + H2O
?
-
-
-
?
human IgG + H2O
?
-
-
-
?
human serum albumin + H2O
?
-
-
-
?
L-Arg-L-Arg-4-nitroanilide + H2O
L-Arg-L-Arg + 4-nitroaniline
-
-
-
?
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg-L-Arg + 7-amino-4-methylcoumarin
L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
mouse T7 trypsinogen mutant D22A/K24G + H2O
?
engineering of a mouse T7 trypsinogen mutant (D22A,K24G), which is robustly activated by cathepsin B but cannot undergo autoactivation
-
-
?
myelin basic protein + H2O
?
-
-
-
?
myoglobin + H2O
hydrolyzed myoglobin
-
-
-
?
myosin + H2O
hydrolyzed myosin
-
-
-
?
myristoylated alanine-rich C kinase substrate + H2O
?
-
i.e. MARCKS
-
-
?
myristoylated alanine-rich C kinase substrate + H2O
p40 + ?
-
i.e. MARCKS
-
?
N,N'-diBoc-dityrosine-Gly-(isoniazid)2 + H2O
?
-
-
-
?
N,N'-diBoc-dityrosine-Lys-(isoniazid)2 + H2O
?
-
-
-
?
N,N-dimethyl hemoglobin + H2O
hydrolyzed N,N-dimethyl hemoglobin
Dorytheuthis bleekeri
-
-
-
?
N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine-4-methyl-7-coumarylamide + H2O
N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine + 4-methyl-7-coumarylamine
-
-
-
-
?
N-benzoyl-Arg-Arg-4-nitroanilide + H2O
N-benzoyl-Arg-Arg + 4-nitroaniline
-
-
-
?
N-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzoyl-L-Arg-2-naphthylamide + H2O
N-benzoyl-L-Arg + 2-naphthylamine
-
-
-
?
N-benzoyl-Val-Asn-Leu-7-amido-4-methylcoumarin + H2O
N-benzoyl-Val-Lys-Met + 7-amino-4-methylcoumarin
-
the substrate represents the wild-type beta-secretase site
-
-
?
N-benzoyl-Val-Lys-Met-7-amido-4-methylcoumarin + H2O
N-benzoyl-Val-Lys-Met + 7-amino-4-methylcoumarin
-
the substrate represents the wild-type beta-secretase site
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-L-arginyl-L-arginyl-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-arginyl-L-arginine + 7-amino-4-methylcoumarin
-
substrate of mature cathepsin B, also procathepsin B is catalytically active on the synthetic substrate but to a lower extent. The unfolded proenzymeis inactive
-
-
?
N-benzyloxycarbonyl-L-Leu-L-Arg 7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Leu-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
?
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-L-lysine + 4-nitrophenol
-
-
-
-
?
N-benzyloxycarbonyl-L-Val-Lys-Lys-Arg-beta-naphthylamide + H2O
N-benzyloxycarbonyl-L-Val-Lys-Lys-Arg + beta-naphthylamine
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Phe-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Val-Ile-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Val-Ile-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Val-Ile-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Val-Ile-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-carbobenzoxy-L-lysine 4-nitrophenyl ester + H2O
N-carbobenzoxy-L-Lys + 4-nitrophenol
-
-
-
-
?
N-carbobenzoxy-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
N-carbobenzoxy-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-CBZ-L-Arg-L-Arg-7-amido- 4-methylcoumarin + H2O
N-CBZ-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-t-butyloxycarbonyl-Gln-p-nitrophenyl ester + H2O
N-t-butyloxycarbonyl-Gln + 4-nitrophenol
-
-
-
?
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Phe-Arg + 7-amino-4-methylcoumarin
Nalpha-benzoyl-Val-Lys-Lys-Arg-7-amido-4-trifluoromethylcoumarin + H2O
?
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-trifluoromethylcoumarin
-
-
-
?
Nalpha-CBZ-Arg-Arg 7-amido-4-methylcoumarin + H2O
Nalpha-CBZ-Arg-Arg + 7-amino-4-methylcoumarin
1 mM DTT
-
-
?
neuropeptides + H2O
hydrolyzed neuropeptides
-
such as Leu-enkephalin, beta-neoendorphin, alpha-neoendorphin, dynorphin(1-13), substance P
-
?
o-aminobenzoic acid-L-Lys-L-Leu-Gly-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-Gly-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)serine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)serine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)threonine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)threonine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(S-benzyl)cysteine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(S-benzyl)cysteine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-Arg-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-Arg-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-Phe-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-Phe-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
-
-
-
?
o-aminobenzoyl-L-Phe-L-Arg-L-Lys-epsilon-N-2,4-dinitrophenylamide + H2O
?
-
-
-
?
ovalbumin + H2O
?
-
-
-
-
?
Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O
?
phenylacetyl-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
phenylacetyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
phenylacetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
phenylacetyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
pro-rhoptry protein 2 + H2O
rhoptry protein 2 + propeptide
-
-
-
?
Protamine + H2O
Hydrolyzed protamine
-
-
-
?
protein rGSII-D88N + H2O
?
proteoglycans + H2O
hydrolyzed proteoglycans
-
-
-
?
serum albumin + H2O
partially degraded serum albumin
-
-
-
?
sheep immunoglobulin heavy chain + H2O
hydrolyzed sheep immunoglobulin heavy chain
-
-
-
?
sphingosine kinase-1 + H2O
?
-
cleaves at histidine 122 and arginine 199
-
-
?
Suc-Leu-Leu-Val-Tyr-7-amido-4-methylcoumarin + H2O
Suc-Leu-Leu-Val-Tyr + 7-amino-4-methylcoumarin
6% of the activity compared to benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
-
?
Tos-Gly-Pro-Arg-4-methyl-7-amidocoumarin + H2O
Tos-Gly-Pro-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
Tos-Gly-Pro-Arg-4-methylcoumarin 7-amide + H2O
Tos-Gly-Pro-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
trypsinogen + H2O
trypsin + ?
1 mM DTT, 1 mM EDTA, pH 4.1, room temperature
-
-
?
trypsinogen + H2O
trypsin + peptide
-
-
-
-
?
trypsinogen activation peptide + H2O
?
1 mM DTT, 1 mM EDTA, pH 4.1, room temperature
-
-
?
Type I collagen + H2O
?
-
-
-
?
yolk protein + H2O
?
-
-
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
Z-Arg-Arg-cresyl violet + H2O
Z-Arg-Arg + cresyl violet
-
-
-
?
Z-Arg-Arg-p-nitroanilide + H2O
?
-
1 microM, pH 6.0, 10 nanoM cathepsin B
-
-
?
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O
Z-Arg-Leu + 7-amino-4-methylcoumarin
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O
Z-Arg-Phe + 7-amino-4-methylcoumarin
Z-Arg-Val-7-amido-4-methylcoumarin + H2O
Z-Arg-Val + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, preferred substrate
-
-
?
Z-arginyl-arginyl-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
37°C, pH 5.5, 5 mM DTT
-
-
?
Z-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
Z-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-L-Phe-L-Arg 7-amido-4-methylcoumarin + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
Z-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
additional information
?
-
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O
?
-
exopeptidase activity
-
-
?
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O
?
exopeptidase activity
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
-
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
-
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
-
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
-
-
-
?
amyloid beta peptide + H2O
?
-
-
-
-
?
amyloid beta peptide + H2O
?
-
cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview
-
-
?
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
-
-
-
?
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
-
-
-
?
azocasein + H2O
fragments of azocasein
-
poor substrate
-
-
?
azocasein + H2O
fragments of azocasein
-
-
-
?
azocasein + H2O
fragments of azocasein
-
-
-
?
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
-
-
-
?
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
-
-
-
?
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
-
-
-
?
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
-
-
-
?
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
Dorytheuthis bleekeri
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
Dorytheuthis bleekeri
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
-
-
-
?
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
-
-
-
?
benzoyl-Phe-Val-Arg-p-nitroanilide + H2O
benzoyl-Phe-Val-Arg + p-nitroaniline
-
-
-
?
benzoyl-Phe-Val-Arg-p-nitroanilide + H2O
benzoyl-Phe-Val-Arg + p-nitroaniline
-
-
-
?
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
-
-
-
?
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
endopeptidase activity
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
17% of the activity compared to benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
-
-
?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Lys-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Lys-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + 4-nitrophenol
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
low activity with cathepsin B3 and B2, higher activity with cathepsin B1 and B4
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
-
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
-
-
-
?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
a fluorogenic substrate of Na-CP-3
-
-
?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
an endoproteolytic substrate
-
-
?
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin
-
a fluorogenic substrate
-
-
?
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
a fluorogenic substrate
-
-
?
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
-
a fluorogenic substrate
-
-
?
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
-
a fluorogenic substrate of Na-CP-3
-
-
?
casein + H2O
hydrolyzed casein
-
-
-
?
casein + H2O
hydrolyzed casein
-
-
-
?
casein + H2O
hydrolyzed casein
-
-
-
?
Collagen + H2O
?
-
-
-
-
?
Collagen + H2O
?
-
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
-
-
?
Collagen + H2O
Hydrolyzed collagen
-
-
-
?
Collagen IV + H2O
?
-
-
-
-
?
Collagen IV + H2O
?
-
quenched fluorescent protein
-
-
?
Collagen IV + H2O
?
-
-
-
-
?
Collagen IV + H2O
?
-
collagen IV of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
-
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
-
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
-
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
quenched fluorescent protein
-
-
?
Gelatin + H2O
?
-
-
-
-
?
Gelatin + H2O
?
-
a substrate of Na-CP-3
-
-
?
Hemoglobin + H2O
?
-
-
-
-
?
Hemoglobin + H2O
?
-
-
-
?
IgG + H2O
?
-
-
-
?
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Laminin + H2O
?
-
-
-
-
?
Laminin + H2O
?
-
laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
-
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
?
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O
?
-
albumin-binding prodrug of doxorubicin, which incorporates a maleimide moiety and a 4-aminobenzyloxycarbonyl spacer coupled to the dipeptide Phe-Lys, is cleaved by cathepsin B and in tumor homogenates of MDA-MB 435 tumor cells from in vitro culture transplanted subcutaneously into the left flank region of mice, overview
-
-
?
Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O
?
-
albumin-binding prodrug of doxorubicin, which incorporates a maleimide moiety and a 4-aminobenzyloxycarbonyl spacer coupled to the dipeptide Phe-Lys, is cleaved by cathepsin B
-
-
?
protein rGSII-D88N + H2O
?
-
-
-
?
protein rGSII-D88N + H2O
?
-
degradation
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
enzyme activation and conversion of precursor proteins to their active form
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
Dorytheuthis bleekeri
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
34990, 34991, 36622, 36626, 36632, 36634, 36641, 36647, 36650, 36662, 36665 -
-
?
Proteins + H2O
?
-
plays a role in cancer invasion and metastasis
-
-
?
Proteins + H2O
?
-
muscle proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
-
-
-
?
Proteins + H2O
?
-
degradation of tissue proteins within lysosomes
-
-
?
Proteins + H2O
?
-
turnover of intracellular proteins
-
-
?
Proteins + H2O
?
-
-
-
-
?
TNF-alpha + H2O
?
-
-
-
-
?
TNF-alpha + H2O
?
-
cathepsin B is required for optimal posttranslational processing of TNF-alpha
-
-
?
TNF-alpha + H2O
?
-
-
-
-
?
TNF-alpha + H2O
?
-
cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides
-
-
?
TNF-alpha + H2O
?
-
-
-
-
?
TNF-alpha + H2O
?
-
cathepsin B is required for optimal posttranslational processing of TNF-alpha in response to the bacterial cell wall component lipopolysacchrides
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
1 mM DTT, 2 mM EDTA, pH 6.8, 37°C, activity varied from 0.013 to 3.4 U/mg protein in normal tissue and from 0.007 to 20.0 U/mg protein in cancer tissue
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
pH 5, 1 mM EDTA, 4 mM DTT
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
20 mM DTT, pH 5.5
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
37°C, pH 6.0, 8 mM DTT, 352 mM KH2PO4, 48 mM Na2HPO4, 4 mM disodium EDTA
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, least preferred substrate
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, negligible hydrolysis
-
-
?
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O
Z-Arg-Leu + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature
-
-
?
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O
Z-Arg-Leu + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, less than 25% hydrolysis compared to Z-Arg-Val-7-amido-4-methylcoumarin
-
-
?
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O
Z-Arg-Phe + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature
-
-
?
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O
Z-Arg-Phe + 7-amino-4-methylcoumarin
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, less than 25% hydrolysis compared to Z-Arg-Val-7-amido-4-methylcoumarin
-
-
?
Z-L-Phe-L-Arg 7-amido-4-methylcoumarin + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
-
?
Z-L-Phe-L-Arg 7-amido-4-methylcoumarin + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
-
-
-
?
additional information
?
-
differential regulation of snail cathepsin B transcript pre- and postparasite exposure, overview
-
-
?
additional information
?
-
-
differential regulation of snail cathepsin B transcript pre- and postparasite exposure, overview
-
-
?
additional information
?
-
CmCatB2 may be an inactive protease isoform resulting from splicing errors
-
-
?
additional information
?
-
CmCatB2 may be an inactive protease isoform resulting from splicing errors
-
-
?
additional information
?
-
-
CmCatB2 may be an inactive protease isoform resulting from splicing errors
-
-
?
additional information
?
-
the enzyme shows substantial exopeptidase activity at a relative rate of 34.26% compared to human cathepsin B
-
-
?
additional information
?
-
-
the enzyme shows substantial exopeptidase activity at a relative rate of 34.26% compared to human cathepsin B
-
-
?
additional information
?
-
-
Boc-Val-Leu-Lys-4-methylcoumarin 7-amide is no substrate of catB1. CatB1 substrate specificity, homology modelling and molecular dynamics simulations of FhcatB1 interaction with peptide substrates, molecular modelling, overview. A P2 Ile residue positions the substrate optimally for interaction with catalytic residues of the enzyme, and the enzyme lacks an occluding loop His residue crucial for exopeptidase activity. The enzyme performs autolytic processing
-
-
?
additional information
?
-
enzyme prefers dipeptidyl pathway over monopeptidyl carboxypeptidase pathway
-
?
additional information
?
-
enzyme prefers large aromatic residues at S2' subsite and the exopeptidase activity prefers aromatic side chains in P2' position
-
?
additional information
?
-
-
enzyme prefers large aromatic residues at S2' subsite and the exopeptidase activity prefers aromatic side chains in P2' position
-
?
additional information
?
-
-
preference for substrate cleavage through dipeptidyl pathway, influence of substrate P2-P1 residues
-
?
additional information
?
-
cathepsin B can partially process the 48000 Da intermediate into 34000 Da mature cathepsin D
-
-
?
additional information
?
-
-
cathepsin B can partially process the 48000 Da intermediate into 34000 Da mature cathepsin D
-
-
?
additional information
?
-
no reaction with Abz-GIVRPK(Dnp)-OH
-
-
?
additional information
?
-
-
no reaction with Abz-GIVRPK(Dnp)-OH
-
-
?
additional information
?
-
no reaction with procarboxypeptidase and proelastase
-
-
?
additional information
?
-
-
no reaction with procarboxypeptidase and proelastase
-
-
?
additional information
?
-
-
cathepsin B is able to self-activate
-
-
?
additional information
?
-
-
autocatalytic activation of the inactive proenzyme
-
-
?
additional information
?
-
cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness
-
-
?
additional information
?
-
-
cathepsin B is a target of Hedgehog signaling in pancreatic cancer, downregulation of CATB by Hedgehog, cyclopamine reduces CATB protein and mRNA levels. CATB might influence pancreatic cancer cell invasiveness
-
-
?
additional information
?
-
-
cathepsin B is an intracellular lysosomal cysteine proteinase that can degrade extracellular components including collagen and protein turnover in the lysosomal system. Cathepsin B plays an important role in the resolution of organic matrix, a final step in bone resorption. It is also known to play an important role in the initiation and perpetuation of inflammatory processes
-
-
?
additional information
?
-
-
cathepsin B is expressed in cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview
-
-
?
additional information
?
-
-
cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
-
-
?
additional information
?
-
-
cathepsin B, together with cathepsin L, urokinase-type plasminogen activator and its inhibitor PAI-1, plays an important role in colorectal cancer invasion. Correlation analysis of proteolytic enzymes in colorectal cancer, overview
-
-
?
additional information
?
-
-
cathepsin-B is a lysosomal cysteine proteasewith broad substrate specificity, which belongs to a family of 11 cysteine proteases. The enzyme is involved in tumor progression, e.g. of endometrial carcinomas
-
-
?
additional information
?
-
-
cysteine cathepsins play a critical role in the biologic activity of tumor-shed vesicles at acidic pH, but not at physiological pH, endothelial cell invasiveness is increased by tumor-shed vesicles exposed to acidic pH, overview
-
-
?
additional information
?
-
disturbances in the regulation of the intracellular activities and uncontrolled release of cathepsins from lysosomes have been implicated in many disease states, such as osteoporosis, inflammatory diseases, and tumor progression
-
-
?
additional information
?
-
-
disturbances in the regulation of the intracellular activities and uncontrolled release of cathepsins from lysosomes have been implicated in many disease states, such as osteoporosis, inflammatory diseases, and tumor progression
-
-
?
additional information
?
-
-
increased cathepsin B levels in acute and chronic lung diseases resulting from high levels of extracellular neutrophil elastase, expression of the protease can be inhibited by alpha1-antitrypsin augmentation therapy
-
-
?
additional information
?
-
-
NF-kappaB induced up-regulation of cathepsin B expression contributes to the invasive property of the 143B cells lacking mtDNA, overview. Extracellularly released cathepsin B can act alone or in concert with some matrix metalloproteinases
-
-
?
additional information
?
-
-
participation of cathepsin B in emodin-induced apoptosis in HK-2 cells, enzyme inhibition by Ca-074 causes significant attenuation the ratio of hypodiploid and apoptotic cells, partially blockage of caspase 3 activation and inhibition of reduction of cell viability induced by emodin, overview
-
-
?
additional information
?
-
-
Porphyromonas gingivalis strain 381 or its lipopolysaccharides increases the expression of cathepsin B in oral epithelial cells
-
-
?
additional information
?
-
-
regulation of cathepsin B in gingival fibroblasts involves interleukin-6 and its receptor along with the Cav-1-JNK-AP-1 pathway, overview
-
-
?
additional information
?
-
-
the enzyme is involved in degradation of extracellular matrix and of basement membrane components leading to tumor invasion in the intestine. Expression of matrix metalloproteinase-9 and cathepsin B is correlated with lymph node metastasis in advanced gastric carcinoma, but not with patients' postoperative survival, overview. Correlation between the synthesis of cysteine and serine proteases and the potential tumor invasion
-
-
?
additional information
?
-
-
the enzyme is involved in extracellular matrix degradation in caveolae of endothelial cells during tube formation, overview. Cathepsin B regulates both pro- and anti-angiogenic factors and may be a contributor to the angiogenic switch of endothelial cells
-
-
?
additional information
?
-
-
the enzyme is involved in inflammatory processes
-
-
?
additional information
?
-
-
the enzyme plays an important role in cancer invasion and metastasis, the enzyme content is positively correlated with tumors in different tissue types
-
-
?
additional information
?
-
-
autocatalytic activation of procathepsin B is largely insensitive to mutations in the cleavage site region and can proceed at neutral pH when bound to heparin and other negatively charged surfaces, which may account for an extracellular physiological role of cathepsins
-
-
?
additional information
?
-
-
cathepsin B is a cysteine protease with both endopeptidase and exopeptidase activity
-
-
?
additional information
?
-
-
No activity with Boc-Val-Pro-Arg-4-methyl-7-amidocoumarin, Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin, and D-Val-Leu-Arg-4-methyl-7-amidocoumarin. Wild-type cathepsin B exhibits exopeptidase activity
-
-
?
additional information
?
-
-
procathepsin B shows autocatalytic processing triggered by proenzyme activity, identification of cleavage sites and initiation mechanism, overview. A multi-step process, starting with a unimolecular conformational change of the zymogen, which unmasks the active site and, in the presence of negatively charged molecules and/or surfaces, also converts the zymogen into a better substrate, followed by the bimolecular proteolytic removal of the propeptide
-
-
?
additional information
?
-
-
the assay uses a modified aminomethylcoumarin dipeptide substrate, which generates a fluorescent signal upon cleavage by cathepsin B
-
-
?
additional information
?
-
active site mapping with peptidic substrates and inhibitors
-
-
?
additional information
?
-
-
active site mapping with peptidic substrates and inhibitors
-
-
?
additional information
?
-
-
no activity with benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin
-
-
?
additional information
?
-
co-incubation of recombinant LycCatB with recombinant Lyc-TR-Ii (invariant chain) leads to an efficient cleavage of recombinant Lyc-TR-Ii
-
-
?
additional information
?
-
-
co-incubation of recombinant LycCatB with recombinant Lyc-TR-Ii (invariant chain) leads to an efficient cleavage of recombinant Lyc-TR-Ii
-
-
?
additional information
?
-
-
absence of Ctsb significantly impairs development of high-grade invasive ductal carcinomas and reduces the metastatic burden in the lungs, and cancer cells lacking Ctsb exhibit significantly higher resistance to apoptosis induction by the lysosomotropic agent Leu-Leu-OMe
-
-
?
additional information
?
-
-
cathepsin B belongs to the lysosomal cysteine cathepsins, a third major class of matrix-degrading enzymes involved in tumor invasion and tissue remodeling. Cathepsin B is involved in matrix degradation at podosomes, cysteine protease inhibitors reduce matrix degradation and invasion in vitro
-
-
?
additional information
?
-
-
cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
-
-
?
additional information
?
-
-
cathepsin B plays an essential role in the pathogenesis of fulminant hepatic failure, and the cathepsin B inhibitor CA-074me can attenuate apoptosis and liver injury, overview
-
-
?
additional information
?
-
-
inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
-
-
?
additional information
?
-
-
the enzyme has a principle function in gross protein degradation of internalized proteins within endo-lysosomes, but cathepsins are also involved in the processing of precursor proteins to biologically active peptides in endosomes of entero-endocrine cells. Cathepsin B, released form intestinal mucosa due to mechanical injury, plays an important role in extracellular matrix damage and the onset of postoperative ileus, an inevitable consequence of abdominal surgery, in that it contributes to disintegration of the basement membrane of the gastrointestinal tract in early post-traumatic phases. Cathepsin B is best known for its critical contribution to enhanced tumor cell invasion and metastasis, including colorectal carcinomas, by degradation of extracellular matrix components
-
-
?
additional information
?
-
-
cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
-
-
?
additional information
?
-
-
no activity with carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin by Na-CP-3, recombinant Na-CP-3 does not digest intact hemoglobin but digests globin fragments generated by prior hydrolysis with aspartic hemoglobinases
-
-
?
additional information
?
-
cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions
-
-
?
additional information
?
-
-
cathepsin B is a lysosomal cysteine protease of the papain-like enzyme family with multiple biological functions
-
-
?
additional information
?
-
-
enzyme is involved in myoblast-myoblast fusion
-
?
additional information
?
-
-
cathepsin B is expressed in induced cerebral aneurysms and promotes the progression of cerebral aneurysms, which include degradation of extracellular matrix in arterial walls in strong subarachnoid hemorrhage, overview
-
-
?
additional information
?
-
-
cathepsin B secreted by activated microglia is closely associated with the MeHg-induced severe pyknotic changes of the cerebellar granule cells, overview. Cathepsin B is involved in apoptotic processes
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additional information
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effective inhibition of cathepsin B can decrease the severity of joint inflammation and to reduce the destruction of particular tissues in the rat model of antigen adjuvant-induced arthritis
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?
additional information
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under certain conditions, e.g. in hypoxia, cathepsin B participates in cleavage of caspase-3 substrates in brain cells
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?
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cathepsin B is a lysosomal cysteine protease, a unique cysteine member showing dual roles as both endopeptidase and exopeptidase activities due to the presence of the occluding loop in structure
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no activity with Arg-7-amido-4-methylcoumarin
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no activity with Arg-7-amido-4-methylcoumarin
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?
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no degradation of hemoglobin
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no degradation of hemoglobin
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?
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no degradation of hemoglobin
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?
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no degradation of hemoglobin
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?
additional information
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no degradation of hemoglobin
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?
additional information
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no degradation of hemoglobin
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?
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no degradation of hemoglobin
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?
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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this isoform encodes an inactive enzyme
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?
additional information
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cathepsin B plays a key role in parasite infection, overview
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additional information
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cathepsin B plays a key role in parasite infection, overview
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