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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

pH Stability

pH Stability on EC 3.4.22.1 - cathepsin B

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pH STABILITY
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
3.3 - 7
-
stable, optimum stability at pH 7.0
36633
3.5 - 7.5
-
encapsulated enzyme
679565
3.6 - 6.5
-
-
36647
4 - 6
-
less stable below and above
36651
4 - 6.5
4 - 6.7
-
stable
36635
4 - 7
4 - 7.5
-
stable
34992
4.5 - 5.5
-
stable
34989
4.5 - 7.5
5 - 7
-
stable
36632
5 - 7.5
-
cleavage activity is more efficient at pH 5.0 than at pH 7.4
678505
5.5
cathepsin B shows high stability in acidic pH 5.5
717439
5.5 - 6.5
7.5
-
no activity at pH 7.5
678362
8
cathepsin B loses stability and activity at pH 8.0, heparin binding prevents cathepsin B destabilization at pH 8.0
717439