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Literature summary for 3.4.22.1 extracted from

  • Vaeaenaenen, A.J.; Salmenperae, P.; Hukkanen, M.; Miranda, K.M.; Harjula, A.; Rauhala, P.; Kankuri, E.
    Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide (2008), Free Radic. Biol. Med., 45, 749-755.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
HNO from Angeli's salt or induced by LPS and IFN-gamma in RAW macrophages, causes DTT-irreversible inhibition and covalently and permanently inactivation of cathepsin B. Cathepsin B activity is reduced to 53%, 25%, and 57% of maximal activity in nonstimulated, LPS-, and IFN-gamma-treated cells, respectively. Endogenous NO production can provide direct protection for the less reactive protein cysteines by scavenging HNO. Additionally, endogenous cellular production of NO can rescue enzyme function by protective nitrosation of cysteines prior to exposure to HNO Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
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Source Tissue

Source Tissue Comment Organism Textmining
RAW-264.7 cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
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Mus musculus N-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
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