Information on EC 3.4.22.1 - cathepsin B

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The expected taxonomic range for this enzyme is: Eukaryota

EC NUMBER
COMMENTARY hide
3.4.22.1
-
RECOMMENDED NAME
GeneOntology No.
cathepsin B
REACTION
REACTION DIAGRAM
COMMENTARY hide
ORGANISM
UNIPROT
LITERATURE
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides
show the reaction diagram
REACTION TYPE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
esterification
-
-
-
-
hydrolysis of peptide bond
-
-
endopeptidase
-
CAS REGISTRY NUMBER
COMMENTARY hide
9047-22-7
-
ORGANISM
COMMENTARY hide
LITERATURE
UNIPROT
SEQUENCE DB
SOURCE
-
-
-
Manually annotated by BRENDA team
Schistosoma mansoni-resistant BS-90, or Salvador strain, and Schistosoma mansoni-susceptible M-line strains
UniProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Capra aegagrus hircus
-
-
Manually annotated by BRENDA team
tongue sole
UniProt
Manually annotated by BRENDA team
-
UniProt
Manually annotated by BRENDA team
Dorytheuthis bleekeri
squid
-
-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
monkey
-
-
Manually annotated by BRENDA team
Monocercomonoides sp.
-
-
-
Manually annotated by BRENDA team
Mus musculus BALB/c
Balb/c mice
-
-
Manually annotated by BRENDA team
Mus musculus C57/Bl
C57/Bl mice
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6
C57BL/6 mice
-
-
Manually annotated by BRENDA team
Mus musculus C57BL/6J
C57BL/6J mice
-
-
Manually annotated by BRENDA team
cathepsin B-like cysteine protease Na-CP-2; cathepsin B-like cysteine protease Na-CP-3; cathepsin B-like cysteine protease Na-CP-4; cathepsin B-like cysteine protease Na-CP-5
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
Japanese flounders, gene PoCatB
UniProt
Manually annotated by BRENDA team
mackerel
-
-
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
strain 90-13
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-
Manually annotated by BRENDA team
strain 90-13
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-
Manually annotated by BRENDA team
-
SwissProt
Manually annotated by BRENDA team
-
-
-
Manually annotated by BRENDA team
GENERAL INFORMATION
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
malfunction
metabolism
-
cathepsin B is involved in TNF-alpha-induced signal transduction pathways in lung cells
physiological function
additional information
SUBSTRATE
PRODUCT                       
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
Reversibility
r=reversible
ir=irreversible
?=not specified
2,4-dinitrophenyl-GARFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GDRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GERFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFAFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFDFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFEFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFFFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFGFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFHFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFIFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFKFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFLFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFPFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFQFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRAW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRDW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFREW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRGW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRHW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRIW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRKW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRLW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRPW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRQW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRRW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRSW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRVW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWA-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWF-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWG-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWI-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWL-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWP-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWQ-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWV-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRWY-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFRYW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFSFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFVFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GFYFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GGRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GHRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GIRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GKRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GLRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GPRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GQRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GRRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GSRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GVRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2,4-dinitrophenyl-GYRFW-OH + H2O
?
show the reaction diagram
-
-
-
?
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-(Nepsilon-2,4-dinitrophenyl)Lys + H2O
2-aminobenzoyl-Gly-Ile-Val-Arg + Ala-(Nepsilon-2,4-dinitrophenyl)Lys
show the reaction diagram
-
an exoproteolytic substrate
-
-
?
2-aminobenzoyl-Gly-Ile-Val-Arg-Ala-Lys(Dnp)-OH + H2O
?
show the reaction diagram
-
exopeptidase activity
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-IEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-IEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
no hydrolysis at pH 6.0
-
?
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-D-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-L-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-D-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-L-Glu + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-LEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-LEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
no hydrolysis at pH 6.0
-
?
4-(4-dimethylaminophenylazo)benzoyl-LRGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-LRGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RIEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RIIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RIIEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
no hydrolysis at pH 6.0
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLEGIE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVG-beta-(2-naphthyl)alanine-E-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVG-beta-(2-naphthyl)alanine-E + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFD-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFD + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVGFL-alpha-aminoadipic acid-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGFL-alpha-aminoadipic acid + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
4-(4-dimethylaminophenylazo)benzoyl-RLVGWE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid + H2O
4-(4-dimethylaminophenylazo)benzoyl-RLVGWE + 5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
show the reaction diagram
-
-
-
?
5-amino-1-(phenylsulfonyl)-1H-pyrazol-3-yl thiophene-2-carboxylate + H2O
5-amino-1-(phenylsulfonyl)-1,2-dihydro-3H-pyrazol-3-one + thiophene-2-carbaldehyde
show the reaction diagram
-
-
-
-
?
5-amino-1-[(4-methoxyphenyl)sulfonyl]-1H-pyrazol-3-yl pyridine-4-carboxylate + H2O
5-amino-1-[(4-methoxyphenyl)sulfonyl]-1,2-dihydro-3H-pyrazol-3-one + pyridine-4-carbaldehyde
show the reaction diagram
-
-
-
-
?
5-dimethylaminonaphthalene-1-sulfonyl-Phe-Arg-Phe(NO2)-Leu + H2O
?
show the reaction diagram
pH 6.4, 37C, 2 mM cysteine, 1 mM EDTA
-
-
?
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-Ala-camptothecin + H2O
?
show the reaction diagram
-
-
major cleavage products are L-Leu-Ala-Leu-Ala-camptothecin, L-Ala-Leu-Ala-camptothecin, L-Leu-Ala-camptothecin, and camptothecin
-
?
6-maleimidocaproic acid-L-Arg-Arg-Ala-Leu-Ala-Leu-doxorubicin + H2O
?
show the reaction diagram
-
-
major cleavage products are L-Leu-Ala-Leu-doxorubicin, L-Leu-doxorubicin, and doxorubicin
-
?
Abz-GIVRAK(Dnp)-OH + H2O
?
show the reaction diagram
-
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37C
-
-
?
Abz-GXXRZK(Dnp)-OH + H2O
?
show the reaction diagram
-
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37C
-
-
?
Abz-GXXZXK(Dnp)-OH + H2O
?
show the reaction diagram
-
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37C
-
-
?
Abz-GXZRXK(Dnp)-OH + H2O
?
show the reaction diagram
-
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37C
-
-
?
Abz-GZXRXK(Dnp)-OH + H2O
?
show the reaction diagram
-
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37C
-
-
?
Ac-Arg-Arg-4-methyl-7-amidocoumarin + H2O
Ac-Arg-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
Ac-His-Pro-Val-Lys-7-amido-3-carbamoylmethyl-4-methylcoumarin + H2O
Ac-His-Pro-Val-Lys + 7-amino-3-carbamoyl-4-methylcoumarin
show the reaction diagram
-
assay at pH 5.5, 37C
-
-
?
acetyl-Arg-Arg-4-methylcoumarin-7-amide + H2O
acetyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
acetyl-Asp-Glu-Val-Asp-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
a synthetic substrate of caspase-3 and caspase-7
-
-
?
acetyl-DEVD-7-amido-4-methylcoumarin + H2O
acetyl-DEVD + 7-amino-4-methylcoumarin
show the reaction diagram
-
cleavage occurs at pH 4.0, but not at pH 7.5
-
-
?
acetyl-F-R-4-methylcoumarin-7-amide + H2O
acetyl-F-R + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
acetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
acetyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Albumin + H2O
?
show the reaction diagram
-
-
-
?
Aldolase + H2O
Hydrolyzed aldolase
show the reaction diagram
alpha-N-benzoyl-DL-Arg-beta-naphthylamide + H2O
alpha-N-benzoyl-DL-Arg + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
amino acid-beta-naphthylamides + H2O
amino acid + beta-naphthylamine
show the reaction diagram
-
-
-
?
amyloid beta peptide + H2O
?
show the reaction diagram
amyloid beta precursor protein + H2O
?
show the reaction diagram
-
cathepsin B selectively cleaves the wild-type beta-secretase site but not the rare Swedish mutant beta-secretase site
-
-
?
amyloid precursor protein C-terminal fragment + H2O
?
show the reaction diagram
-
cathepsin B degraded C-terminal fragments regardless of phosphorylation
-
-
?
amyloid precursor protein intracellular domain + H2O
?
show the reaction diagram
-
-
-
-
?
amyloid-beta + H2O
?
show the reaction diagram
-
-
-
-
?
antiprotease secretory leucoprotease inhibitor + H2O
cleaved SLP1 protein
show the reaction diagram
-
i.e. SLP1 protein, cleavage between residues Thr67 and Tyr68
-
?
Arg-4-methylcoumaryl-7-amide + H2O
Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Arg-beta-naphthylamide + H2O
Arg + beta-naphthylamine
show the reaction diagram
azocasein + H2O
fragments of azocasein
show the reaction diagram
benzoyl-arginine ethyl ester + H2O
benzoyl-arginine + ethanol
show the reaction diagram
benzoyl-DL-Arg-beta-naphthylamide + H2O
benzoyl-DL-Arg + beta-naphthylamine
show the reaction diagram
benzoyl-DL-Arg-p-nitroanilide + H2O
benzoyl-DL-Arg + p-nitroaniline
show the reaction diagram
benzoyl-DL-argininamide + H2O
benzoyl-DL-arginine + NH3
show the reaction diagram
benzoyl-L-3-pyridyl-Ala-l-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-3-pyridyl-Ala-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-4-aminocyclohexy-Ala-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminocyclohexyl-Ala-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-4-aminomethyl-N-isopropyl-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminomethyl-N-isopropyl-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-4-aminomethyl-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-aminomethyl-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-4-guanidine-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-guanidine-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-4-piperidinyl-Ala-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-4-piperidinyl-Ala-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-Arg-beta-naphthylamide + H2O
benzoyl-L-Arg + beta-naphthylamine
show the reaction diagram
-
-
-
?
benzoyl-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-Arg-p-nitroanilide + H2O
benzoyl-L-Arg + p-nitroaniline
show the reaction diagram
benzoyl-L-His-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-His-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-N-dimethyl-His-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-N-dimethyl-His-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzoyl-Phe-Val-Arg-4-methylcoumarin-7-amide + H2O
benzoyl-Phe-Val-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
benzoyl-Phe-Val-Arg-p-nitroanilide + H2O
benzoyl-Phe-Val-Arg + p-nitroaniline
show the reaction diagram
benzoyl-Pro-Phe-Arg-p-nitroanilide + H2O
benzoyl-Pro-Phe-Arg + p-nitroaniline
show the reaction diagram
benzyloxycarbonyl-Ala-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Ala + 4-nitrophenol
show the reaction diagram
-
-
-
-
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Ala-Arg-Arg + 4-methoxy-beta-naphthylamine
show the reaction diagram
benzyloxycarbonyl-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + 4-methoxy-beta-naphthylamine
show the reaction diagram
benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
benzyloxycarbonyl-Arg-Arg-beta-naphthylamide + H2O
benzyloxycarbonyl-Arg-Arg + beta-naphthylamine
show the reaction diagram
benzyloxycarbonyl-Arg-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Arg-Arg + p-nitroaniline
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-FR-4-methylcoumarin-7-amide + H2O
benzyloxycarbonyl-FR + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Gly-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Gly + 4-nitrophenol
show the reaction diagram
-
-
-
-
benzyloxycarbonyl-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
benzyloxycarbonyl-L-Leu-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Leu-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-leucyl-L-arginine-4-methylcoumaryl-7-amide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-L-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-L-phenylalaninyl-L-arginine 4-methylcoumaryl-7-amide + H2O
?
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Lys-4-nitrophenyl ester + H2O
benzyloxycarbonyl-Lys + 4-nitrophenol
show the reaction diagram
benzyloxycarbonyl-Phe-Arg-4-methoxy-beta-naphthylamide + H2O
benzyloxycarbonyl-Phe-Arg + 4-methoxy-beta-naphthylamine
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-4-methylcoumarin-7-amide
benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
benzyloxycarbonyl-L-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
benzyloxycarbonyl-Phe-Arg-p-nitroanilide + H2O
benzyloxycarbonyl-Phe-Arg + p-nitroaniline
show the reaction diagram
-
-
-
?
benzyloxycarbonyl-phenylalanyl-arginine-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, activity at pH 5.0 is 80fold greater than with Arg-Arg
-
-
?
benzyloxycarbonyl-phenylalanyl-arginyl-7-amido-4-methylcoumarin + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
37C, 1 mM DTT, 1 mM EDTA, pH 6.0
-
-
?
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide + H2O
? + 4-methoxy-beta-naphthylamine
show the reaction diagram
beta-lipotropin + H2O
hydrolyzed beta-lipotropin
show the reaction diagram
-
-
-
?
Boc-Asp-Pro-Arg-4-methyl-7-amidocoumarin + H2O
Boc-Asp-Pro-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
Boc-Asp-Pro-Arg-4-methylcoumarin 7-amide + H2O
Boc-Asp-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Boc-L-Leu-L-Lys-L-Arg-4-methylcoumarin-7-amide + H2O
Boc-L-Leu-L-Lys-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
pH-dependence of reaction
-
?
Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin + H2O
Boc-Val-Leu-Lys + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide + H2O
Boc-Val-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
BODIPY FL casein + H2O
?
show the reaction diagram
-
-
-
-
?
Bovine serum albumin + H2O
Hydrolyzed bovine serum albumin
show the reaction diagram
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
carbobenzoxy-Arg-Arg-7-amido-4-methylcoumarin hydrochloride + H2O
carbobenzoxy-Arg-Arg + 7-amino-4-methylcoumarin hydrochloride
show the reaction diagram
-
-
-
-
?
carbobenzoxy-Gly-Gly-Arg-naphthylamide + H2O
? + naphthylamine
show the reaction diagram
-
-
-
?
carbobenzoxy-Phe-Ala-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Ala-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin + H2O
carbobenzoxy-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
casein + H2O
hydrolyzed casein
show the reaction diagram
caspase 1 precursor + H2O
?
show the reaction diagram
-
-
-
-
?
CBZ-Arg-Arg-4-nitroanilide + H2O
CBZ-Arg-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
-
?
CBZ-Arg-Arg-7-amido-4-methylcoumarin + H2O
CBZ-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
endopeptidase activity
-
-
?
Cbz-FR-7-amido-4-methylcoumarin + H2O
Cbz-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
37C, pH 6.0, 200 mM NaCl, 1 mM EDTA, 5 nM DTT
-
-
?
CBZ-L-Arg-L-Arg-4-nitroanilide + H2O
L-Arg-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
Cbz-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O
Cbz-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
CBZ-Phe-Arg-7-amido-4-methylcoumarin + H2O
?
show the reaction diagram
-
-
-
?
chemokine (C-C motif) ligand 20 + H2O
CCL20 1-66 isoform + ?
show the reaction diagram
-
CCL20 is also known as liver- and activation-regulated chemokine (LARC), MIP-3alpha, or exodus-1
cathepsin B specifically cleaves off four C-terminally located amino acids and generates a CCL20 1-66 isoform with full functional activity
-
?
Collagen + H2O
?
show the reaction diagram
Collagen + H2O
Hydrolyzed collagen
show the reaction diagram
Collagen IV + H2O
?
show the reaction diagram
D-Pro-Phe-Arg-p-nitroanilide + H2O
D-Pro-Phe-Arg + p-nitroaniline
show the reaction diagram
-
-
-
?
D-Val-Leu-Arg-4-methylcoumarin 7-amide + H2O
D-Val-Leu-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
D-Val-Leu-Lys-p-nitroanilide + H2O
D-Val-Leu-Lys + p-nitroaniline
show the reaction diagram
-
-
-
?
denatured hemoglobin + H2O
hydrolyzed denatured hemoglobin
show the reaction diagram
DQ-collagen IV + H2O
?
show the reaction diagram
-
-
-
-
?
epithelial sodium channel alpha subunit + H2O
?
show the reaction diagram
-
in vitro cleavage studies show that the full-length ENaC alpha subunit fusion protein is cleaved by active cathepsin B but not the full-length beta or gamma subunit fusion proteins
-
-
?
epsilon-aminocaproic acid-L-Leu-Gly-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-Gly + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)serine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)serine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)threonine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)threonine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(O-methyl)-tyrosine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(O-methyl)-tyrosine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-(S-benzyl)cysteine-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-(S-benzyl)cysteine + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-Leu-L-Phe-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-Leu-L-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
epsilon-aminocaproic acid-L-R-4-methylcoumarin-7-amide + H2O
epsilon-aminocaproic acid-L-R + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Fibronectin + H2O
?
show the reaction diagram
-
-
-
?
filaggrin + H2O
hydrolyzed filaggrin
show the reaction diagram
-
-
-
?
Gelatin + H2O
?
show the reaction diagram
gelatin + H2O
hydrolyzed gelatine
show the reaction diagram
-
-
-
?
globin + H2O
partially degraded globin
show the reaction diagram
-
-
-
?
Glucagon + H2O
Hydrolyzed glucagon
show the reaction diagram
-
-
-
?
Gly-Arg-7-amido-4-methylcoumarin + H2O
Gly-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
a fluorogenic substrate
-
-
?
Hemoglobin + H2O
?
show the reaction diagram
-
-
-
?
Hemoglobin + H2O
Hydrolyzed hemoglobin
show the reaction diagram
-
from goat and from buffalo
-
?
herpes simplex virus type 1 origin binding protein + H2O
herpes simplex virus type 1 origin binding protein 1
show the reaction diagram
-
53 kDa protein
50 kDa protein
-
?
histones + H2O
hydrolyzed histones
show the reaction diagram
-
-
-
?
IgA + H2O
?
show the reaction diagram
-
-
-
?
IgG + H2O
?
show the reaction diagram
L-Arg-L-Arg-4-nitroanilide + H2O
L-Arg-L-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Laminin + H2O
?
show the reaction diagram
myelin basic protein + H2O
?
show the reaction diagram
-
-
-
?
myoglobin + H2O
hydrolyzed myoglobin
show the reaction diagram
-
-
-
?
myosin + H2O
hydrolyzed myosin
show the reaction diagram
-
-
-
?
myristoylated alanine-rich C kinase substrate + H2O
?
show the reaction diagram
-
i.e. MARCKS
-
-
-
myristoylated alanine-rich C kinase substrate + H2O
p40 + ?
show the reaction diagram
-
i.e. MARCKS
-
?
N,N'-diBoc-dityrosine-Gly-(isoniazid)2 + H2O
?
show the reaction diagram
-
-
-
-
?
N,N'-diBoc-dityrosine-Lys-(isoniazid)2 + H2O
?
show the reaction diagram
-
-
-
-
?
N,N-dimethyl hemoglobin + H2O
hydrolyzed N,N-dimethyl hemoglobin
show the reaction diagram
Dorytheuthis bleekeri
-
-
-
?
N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine-4-methyl-7-coumarylamide + H2O
N-alpha-benzyloxycarbonyl-L-arginyl-L-arginine + 4-methyl-7-coumarylamine
show the reaction diagram
-
-
-
-
?
N-benzoyl-Arg-Arg-4-nitroanilide + H2O
N-benzoyl-Arg-Arg + 4-nitroaniline
show the reaction diagram
-
-
-
?
N-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-benzoyl-L-Arg-2-naphthylamide + H2O
N-benzoyl-L-Arg + 2-naphthylamine
show the reaction diagram
N-benzoyl-Val-Asn-Leu-7-amido-4-methylcoumarin + H2O
N-benzoyl-Val-Lys-Met + 7-amino-4-methylcoumarin
show the reaction diagram
-
the substrate represents the wild-type beta-secretase site
-
-
?
N-benzoyl-Val-Lys-Met-7-amido-4-methylcoumarin + H2O
N-benzoyl-Val-Lys-Met + 7-amino-4-methylcoumarin
show the reaction diagram
-
the substrate represents the wild-type beta-secretase site
-
-
?
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Arg-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-L-arginyl-L-arginyl-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-L-arginyl-L-arginine + 7-amino-4-methylcoumarin
show the reaction diagram
-
substrate of mature cathepsin B, also procathepsin B is catalytically active on the synthetic substrate but to a lower extent. The unfolded proenzymeis inactive
-
-
?
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
?
show the reaction diagram
N-benzyloxycarbonyl-L-lysine 4-nitrophenyl ester + H2O
N-benzyloxycarbonyl-L-lysine + 4-nitrophenol
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-L-Val-Lys-Lys-Arg-beta-naphthylamide + H2O
N-benzyloxycarbonyl-L-Val-Lys-Lys-Arg + beta-naphthylamine
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Phe-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Val-Ile-Arg-4-methyl-7-amidocoumarin + H2O
N-benzyloxycarbonyl-Val-Ile-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
N-benzyloxycarbonyl-Val-Ile-Arg-4-methylcoumarin 7-amide + H2O
N-benzyloxycarbonyl-Val-Ile-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-carbobenzoxy-L-lysine 4-nitrophenyl ester + H2O
?
show the reaction diagram
-
-
-
-
?
N-carbobenzoxy-L-Phe-L-Arg-7-amido-4-methylcoumarin + H2O
N-carbobenzoxy-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-CBZ-L-Arg-L-Arg-7-amido- 4-methylcoumarin + H2O
N-CBZ-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
N-t-butyloxycarbonyl-Gln-p-nitrophenyl ester + H2O
N-t-butyloxycarbonyl-Gln + 4-nitrophenol
show the reaction diagram
-
-
-
-
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzoyl-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Nalpha-benzoyl-Val-Lys-Lys-Arg-7-amido-4-trifluoromethylcoumarin + H2O
?
show the reaction diagram
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-methylcoumarin + H2O
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin + H2O
Nalpha-benzyloxycarbonyl-L-Arg-L-Arg + 7-amino-4-trifluoromethylcoumarin
show the reaction diagram
-
-
-
?
Nalpha-CBZ-Arg-Arg 7-amido-4-methylcoumarin + H2O
Nalpha-CBZ-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
1 mM DTT
-
-
?
neuropeptides + H2O
hydrolyzed neuropeptides
show the reaction diagram
-
such as Leu-enkephalin, beta-neoendorphin, alpha-neoendorphin, dynorphin(1-13), substance P
-
?
o-aminobenzoic acid-L-Lys-L-Leu-Gly-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-Gly-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)serine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)serine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)threonine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)threonine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-(S-benzyl)cysteine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-(S-benzyl)cysteine-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-Arg-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-Arg-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoic acid-L-Lys-L-Leu-L-Phe-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine + H2O
o-aminobenzoic acid-L-Lys-L-Leu-L-Phe-L-Phe-L-Ser-L-Lys-L-Gln + 2,4-dinitrophenyl-ethylenediamine
show the reaction diagram
-
-
-
?
o-aminobenzoyl-L-Phe-L-Arg-L-Lys-epsilon-N-2,4-dinitrophenylamide + H2O
?
show the reaction diagram
-
-
-
?
ovalbumin + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O
?
show the reaction diagram
phenylacetyl-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
phenylacetyl-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
phenylacetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
phenylacetyl-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
pro-rhoptry protein 2 + H2O
rhoptry protein 2 + propeptide
show the reaction diagram
-
-
-
?
Protamine + H2O
Hydrolyzed protamine
show the reaction diagram
-
-
-
?
protein rGSII-D88N + H2O
?
show the reaction diagram
Proteins + H2O
?
show the reaction diagram
proteoglycans + H2O
hydrolyzed proteoglycans
show the reaction diagram
-
-
-
?
serum albumin + H2O
partially degraded serum albumin
show the reaction diagram
-
-
-
?
sheep immunoglobulin heavy chain + H2O
hydrolyzed sheep immunoglobulin heavy chain
show the reaction diagram
-
-
-
?
sphingosine kinase-1 + H2O
?
show the reaction diagram
-
cleaves at histidine 122 and arginine 199
-
-
?
TNF-alpha + H2O
?
show the reaction diagram
Tos-Gly-Pro-Arg-4-methyl-7-amidocoumarin + H2O
Tos-Gly-Pro-Arg + 4-methyl-7-aminocoumarin
show the reaction diagram
-
-
-
-
?
Tos-Gly-Pro-Arg-4-methylcoumarin 7-amide + H2O
Tos-Gly-Pro-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
-
?
trypsinogen + H2O
trypsin + ?
show the reaction diagram
-
1 mM DTT, 1 mM EDTA, pH 4.1, room temperature
-
-
?
trypsinogen + H2O
trypsin + peptide
show the reaction diagram
-
-
-
-
?
trypsinogen activation peptide + H2O
?
show the reaction diagram
-
1 mM DTT, 1 mM EDTA, pH 4.1, room temperature
-
-
?
Type I collagen + H2O
?
show the reaction diagram
-
-
-
?
yolk protein + H2O
?
show the reaction diagram
-
-
-
-
?
Z-Arg-Arg-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Arg-Arg-cresyl violet + H2O
Z-Arg-Arg + cresyl violet
show the reaction diagram
-
-
-
-
?
Z-Arg-Arg-p-nitroanilide + H2O
?
show the reaction diagram
-
1 microM, pH 6.0, 10 nanoM cathepsin B
-
-
?
Z-Arg-Leu-7-amido-4-methylcoumarin + H2O
Z-Arg-Leu + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Arg-Phe-7-amido-4-methylcoumarin + H2O
Z-Arg-Phe + 7-amino-4-methylcoumarin
show the reaction diagram
Z-Arg-Val-7-amido-4-methylcoumarin + H2O
Z-Arg-Val + 7-amino-4-methylcoumarin
show the reaction diagram
2 mM DTT, pH 3.0-8.0, 0.3 M NaCl, room temperature, preferred substrate
-
-
?
Z-arginyl-arginyl-7-amido-4-methylcoumarin + H2O
Z-Arg-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
37C, pH 5.5, 5 mM DTT
-
-
?
Z-L-Arg-L-Arg-4-methylcoumarin-7-amide + H2O
Z-L-Arg-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Z-L-Phe-L-Arg 7-amido-4-methylcoumarin + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
Z-L-Phe-L-Arg-4-methylcoumarin-7-amide + H2O
Z-L-Phe-L-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
-
-
-
?
Z-Phe-Arg-4-methylcoumarin-7-amide + H2O
Z-Phe-Arg + 7-amino-4-methylcoumarin
show the reaction diagram
additional information
?
-
NATURAL SUBSTRATES
NATURAL PRODUCTS
REACTION DIAGRAM
ORGANISM
UNIPROT
COMMENTARY
(Substrate) hide
LITERATURE
(Substrate)
COMMENTARY
(Product) hide
LITERATURE
(Product)
REVERSIBILITY
r=reversible
ir=irreversible
?=not specified
amyloid beta peptide + H2O
?
show the reaction diagram
-
cathepsin B is involved in degradation of amyloid beta peptides, its inhibition can lead to amyloid beta accumulation, an early trigger of Alzheimer's disease, cystatin C regulates the enzyme negatively, CysC ablation ameliorates amyloid beta-associated neuronal and synaptic deficits in hippocampal circuits, neuroprotective effects of CysC ablation depend on CatB, overview
-
-
?
amyloid beta precursor protein + H2O
?
show the reaction diagram
-
cathepsin B selectively cleaves the wild-type beta-secretase site but not the rare Swedish mutant beta-secretase site
-
-
?
amyloid-beta + H2O
?
show the reaction diagram
-
-
-
-
?
caspase 1 precursor + H2O
?
show the reaction diagram
-
-
-
-
?
Collagen + H2O
?
show the reaction diagram
Collagen IV + H2O
?
show the reaction diagram
Gelatin + H2O
?
show the reaction diagram
Laminin + H2O
?
show the reaction diagram
-
laminin of the basement membrane damaged by cathepsin B, that is released after mechanical injury, during initial post-traumatic stages, overview
-
-
?
myristoylated alanine-rich C kinase substrate + H2O
?
show the reaction diagram
-
i.e. MARCKS
-
-
-
ovalbumin + H2O
?
show the reaction diagram
-
-
-
-
?
Phe-Lys-4-aminobenzyloxycarbonyl-doxorubicin prodrug-albumin + H2O
?
show the reaction diagram
-
albumin-binding prodrug of doxorubicin, which incorporates a maleimide moiety and a 4-aminobenzyloxycarbonyl spacer coupled to the dipeptide Phe-Lys, is cleaved by cathepsin B and in tumor homogenates of MDA-MB 435 tumor cells from in vitro culture transplanted subcutaneously into the left flank region of mice, overview
-
-
?
Proteins + H2O
?
show the reaction diagram
TNF-alpha + H2O
?
show the reaction diagram
additional information
?
-