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Literature summary for 3.4.22.1 extracted from

  • Gole, B.; Duran Alonso, M.B.; Dolenc, V.; Lah, T.
    Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro (2009), Pathol. Oncol. Res., 15, 711-723.
    View publication on PubMed
Search for more literature for 3.4.22.1

Protein Variants

Protein Variants Comment Organism
additional information CatB silencing with siRNA in U87-MG cells Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
iodoacetic acid complete inhibition at 1 mM Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Homo sapiens 5764
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
glioblastoma cell expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma Homo sapiens
-
SNB-19 cell a glioblastoma cell line Homo sapiens
-
U-87MG cell a glioblastoma cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide + H2O
-
 Homo sapiens N-benzyloxycarbonyl-Arg-Arg + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
CatB
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Homo sapiens

Expression

Organism Comment Expression
Homo sapiens expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma up

General Information

General Information Comment Organism
malfunction the activity of CatB, but not of CatL or CatS, is relevant to glioblastoma invasion, role of cathepsin B in glioma invasion by in vitro 3D spheroids migration modelling of in vivo glioma growth and invasion, overview Homo sapiens