3.4.22.1: cathepsin B
This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.
Word Map on EC 3.4.22.1
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3.4.22.1
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cathepsins
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lysosomal
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proteinases
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papain
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collagen
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metastasis
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pancreatic
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cystatins
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procathepsin
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upa
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exopeptidase
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food industry
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myofibrillar
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mansoni
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schistosoma
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lc3-ii
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calpains
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permeabilization
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zymogen
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intralysosomal
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leupeptin
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peptidase
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hyperamylasemia
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pharmacology
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papain-like
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diagnostics
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biotechnology
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collagenase
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antibody-drug
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autophagy-lysosome
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pepstatin
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acinar
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ficin
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plasminogen
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caspase-1
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proenzyme
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legumain
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autophagosomes
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elastase
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caerulein
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caerulein-induced
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molecular biology
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dipeptidyl
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fluorogenic
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inflammasome
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endosomes
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pro-il-1
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supramaximal
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l-like
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b-mediated
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fasciola
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mu-calpain
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medicine
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trypsinogen
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hepatica
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drug development
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collagenolytic
- 3.4.22.1
- cathepsins
- lysosomal
- proteinases
- papain
- collagen
- metastasis
- pancreatic
- cystatins
-
procathepsin
- upa
-
exopeptidase
- food industry
- myofibrillar
- mansoni
- schistosoma
-
lc3-ii
- calpains
-
permeabilization
- zymogen
-
intralysosomal
- leupeptin
- peptidase
-
hyperamylasemia
- pharmacology
-
papain-like
- diagnostics
- biotechnology
- collagenase
-
antibody-drug
-
autophagy-lysosome
- pepstatin
-
acinar
- ficin
- plasminogen
- caspase-1
- proenzyme
- legumain
-
autophagosomes
- elastase
- caerulein
-
caerulein-induced
- molecular biology
-
dipeptidyl
-
fluorogenic
- inflammasome
- endosomes
-
pro-il-1
-
supramaximal
-
l-like
-
b-mediated
- fasciola
- mu-calpain
- medicine
- trypsinogen
- hepatica
- drug development
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collagenolytic
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =
Synonyms
AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2
ECTree
3.4.22.1 cathepsin BAdvanced search results
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results (Source Tissue
Source Tissue on EC 3.4.22.1 - cathepsin B
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SOURCE TISSUE 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
SOURCE
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tubular adenomas with low grade dysplasia and tubulovillous adenomas with high grade dysplasia
type 1 alveolar epithelial (R3/1) cell
expressed in later juvenile stages and the mature worm
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endometrial glands and epithelial cells, and also stroma
in metacercaria and cercaria, four cathepsin Bs can be detected in the excretory vesicle and oral sucker
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primarily, expression profile of cathepsin B in the fat body during metamorphosis, overview. CatB shows a high expression level during the larval-pupal transformation
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of a more aggressive tumor type, cathepsin B is most common in the intestinal type tumors infiltrating the whole gastric wall
in adult worm, four cathepsin Bs can be specifically observed in the intestinal tract
in metacercaria and cercaria, four cathepsin Bs can be detected in the excretory vesicle and oral sucker
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up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells resulting, at least in part, from the activation of the transcription factor NF-kappaB
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epithelial, cathepsin B is significantly higher in patients older than compared with patients younger than 57 years of age
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in contrast to AC-cathB-1, only AC-cathB-2 is expressed in the reproductive system
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enzyme before and after canine extraction, force application reduces the enzyme activity in gingival crevicular fluid to 41.5% of maximal activity
highest expression in Wharton's jelly and the lowest in the umbilical cord arteries
additional information
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cathepsin B is expressed in cerebral aneurysms and aneurysmal walls, and promotes the progression of cerebral aneurysms
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cathepsin B is expressed in induced cerebral aneurysms and aneurysmal walls, and promotes the progression of cerebral aneurysms
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from patients with alpha1-antitrypsin deficiency, pneumonia and healthy individuals
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myeloid and plasmacytoid dendritic cells differ in their cathepsin distribution, overview
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expression of cathepsins B, L and S gradually increases in the progression from benign astrocytoma to the malignant glioblastoma
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the most frequent malignant brain tumor in adults, increased expression of cathepsin B compared to healthy astrocytes, immunohistochemic and expression analysis, overview
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Na-CP-2 is up-regulated during the transition from a free-living larva to a blood-feeding adult worm
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Na-CP-3 is up-regulated during the transition from a free-living larva to a blood-feeding adult worm
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Na-CP-4 is up-regulated during the transition from a free-living larva to a blood-feeding adult worm
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Na-CP-5 is up-regulated during the transition from a free-living larva to a blood-feeding adult worm
the CpCathB protein has a higher expression in hepatopancreas and mantle and a lower level in hemocytes
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negligible expression of cathepsin B in hepatic stellate cells
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negligible expression of cathepsin B in hepatic stellate cells
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the CpCathB protein has a higher expression in hepatopancreas and mantle and a lower level in hemocytes
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mucosa and muscle, cathepsin B is abundantly expressed in endocytic compartments of all cells of the intestine
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the enzyme is expressed significantly higher in the fourth-stage larvae and the fifth-stage larvae than that in the third-stage larvae and adult worms
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34990, 36626, 36634, 36650, 650355, 650517, 652163, 653026, 673671, 681231, 699388, 701102, 708264, 708641, 717583, 718179
of healthy mussels. The CpCathB protein has a higher expression in hepatopancreas and mantle and a lower level in hemocytes
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isolated from the mixed primary cell cultures from the cerebral cortex of 3-day-old wild-type or CB-/- mice, activated by chromogranin A
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isolated from the mixed primary cell cultures from the cerebral cortex of 3-day-old wild-type or CB-/- mice, activated by chromogranin A
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of ovarian tumors, the levels of CatB depend on the tumor subtypes, overview. CatB levels are signifiantly higher in cystic fluid of malignant serous tumors compared to those found in benign serous tumors
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from subcutaneous heteroplastic pancreatic carcinoma, quantitative cathepsin B expression analysis and modelling
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enzyme levels in serum from patients with colorectal, gastric, hepatocellular, or pancreatic cancers and gastric epithelial dysplasia, overview
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extracellular, secreted enzyme, the enzyme content is higher in blood from patients with pelvic inflammatory disease compared to control healthy women, overview
additional information
CatB2 is expressed only in early stages of the parasite
additional information
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CatB2 is expressed only in early stages of the parasite
additional information
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immunohistochemic expression analysis in cerebral arterial walls and aneurysms, overview
additional information
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JNK inhibition, but not p44/42 MAPK inhibition, significantly diminishes interleukin-6/soluble form of IL-6 receptor-induced cathepsin B production
additional information
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quantitative determination of cathepsin B tissue distribution
additional information
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two mouse models of Alzheimer's Disease, consisting of one expressing human amyloid precursor protein containing the wild-type beta-secretase site and mutation at the beta-secretase site, London amyloid precursor protein mice, and the other expressing the Swe mutant beta-secretase site and the London mutation, Swedish/London amyloid precursor protein
additional information
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cathepsin B is expressed ubiquitously and represents the major portion of lysosomal enzymes
additional information
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during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes
additional information
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during in vivo liver fibrogenesis, caused by CCl4 administration, CtsB expression increases in hepatic stellate cells but not in hepatocytes
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additional information
expression is detected in the trophozoite stage but not in the cyst stage
additional information
expression is detected in the trophozoite stage but not in the cyst stage
additional information
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expression is detected in the trophozoite stage but not in the cyst stage
additional information
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developmental expression pattern, the isozyme is highly up-regulated in the adult stage, overview
additional information
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developmental expression patterns, the isozymes are highly up-regulated in the adult stage, overview
additional information
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the enzyme is not expressed in pleopods and eye stalk
additional information
expression is the highest in females, followed by juveniles and eggs, and is the lowest in males
additional information
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expression is the highest in females, followed by juveniles and eggs, and is the lowest in males
additional information
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immunohistochemic expression analysis in cerebral arterial walls and aneurysms, overview
