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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

KM Value

KM Value on EC 3.4.22.1 - cathepsin B

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KM VALUE [mM]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
0.0161
2,4-dinitrophenyl-GARFW-OH
-
pH 6.0, 37°C
0.0096
2,4-dinitrophenyl-GDRFW-OH
-
pH 6.0, 37°C
0.012
2,4-dinitrophenyl-GERFW-OH
-
pH 6.0, 37°C
0.0016
2,4-dinitrophenyl-GFAFW-OH
-
pH 6.0, 37°C
0.0034
2,4-dinitrophenyl-GFDFW-OH
-
pH 6.0, 37°C
0.0008
2,4-dinitrophenyl-GFEFW-OH
-
pH 6.0, 37°C
0.0005
2,4-dinitrophenyl-GFFFW-OH
-
pH 6.0, 37°C
0.0014
2,4-dinitrophenyl-GFGFW-OH
-
pH 6.0, 37°C
0.0007
2,4-dinitrophenyl-GFHFW-OH
-
pH 6.0, 37°C
0.0021
2,4-dinitrophenyl-GFKFW-OH
-
pH 6.0, 37°C
0.0005 - 0.0017
2,4-dinitrophenyl-GFLFW-OH
0.0006
2,4-dinitrophenyl-GFQFW-OH
-
pH 6.0, 37°C
0.0052
2,4-dinitrophenyl-GFRAW-OH
-
pH 6.0, 37°C
0.0053
2,4-dinitrophenyl-GFRDW-OH
-
pH 6.0, 37°C
0.0096
2,4-dinitrophenyl-GFREW-OH
-
pH 6.0, 37°C
0.0012
2,4-dinitrophenyl-GFRFW-OH
-
pH 6.0, 37°C
0.0077
2,4-dinitrophenyl-GFRGW-OH
-
pH 6.0, 37°C
0.0045
2,4-dinitrophenyl-GFRHW-OH
-
pH 6.0, 37°C
0.0033
2,4-dinitrophenyl-GFRIW-OH
-
pH 6.0, 37°C
0.0008
2,4-dinitrophenyl-GFRKW-OH
-
pH 6.0, 37°C
0.0021
2,4-dinitrophenyl-GFRLW-OH
-
pH 6.0, 37°C
0.0045
2,4-dinitrophenyl-GFRQW-OH
-
pH 6.0, 37°C
0.005
2,4-dinitrophenyl-GFRRW-OH
-
pH 6.0, 37°C
0.0095
2,4-dinitrophenyl-GFRSW-OH
-
pH 6.0, 37°C
0.0018
2,4-dinitrophenyl-GFRVW-OH
-
pH 6.0, 37°C
0.009
2,4-dinitrophenyl-GFRWA-OH
-
pH 6.0, 37°C
0.0055
2,4-dinitrophenyl-GFRWD-OH
-
pH 6.0, 37°C
0.0106
2,4-dinitrophenyl-GFRWE-OH
-
pH 6.0, 37°C
0.0022
2,4-dinitrophenyl-GFRWF-OH
-
pH 6.0, 37°C
0.0162
2,4-dinitrophenyl-GFRWG-OH
-
pH 6.0, 37°C
0.012
2,4-dinitrophenyl-GFRWI-OH
-
pH 6.0, 37°C
0.0126
2,4-dinitrophenyl-GFRWK-OH
-
pH 6.0, 37°C
0.0042
2,4-dinitrophenyl-GFRWL-OH
-
pH 6.0, 37°C
0.0124
2,4-dinitrophenyl-GFRWP-OH
-
pH 6.0, 37°C
0.0115
2,4-dinitrophenyl-GFRWR-OH
-
pH 6.0, 37°C
0.0128
2,4-dinitrophenyl-GFRWS-OH
-
pH 6.0, 37°C
0.0223
2,4-dinitrophenyl-GFRWV-OH
-
pH 6.0, 37°C
0.0066
2,4-dinitrophenyl-GFRWY-OH
-
pH 6.0, 37°C
0.0036
2,4-dinitrophenyl-GFRYW-OH
-
pH 6.0, 37°C
0.0012
2,4-dinitrophenyl-GFSFW-OH
-
pH 6.0, 37°C
0.0004
2,4-dinitrophenyl-GFVFW-OH
-
pH 6.0, 37°C
0.0011
2,4-dinitrophenyl-GFYFW-OH
-
pH 6.0, 37°C
0.0086
2,4-dinitrophenyl-GHRFW-OH
-
pH 6.0, 37°C
0.0019
2,4-dinitrophenyl-GIRFW-OH
-
pH 6.0, 37°C
0.0041
2,4-dinitrophenyl-GKRFW-OH
-
pH 6.0, 37°C
0.0106
2,4-dinitrophenyl-GLRFW-OH
-
pH 6.0, 37°C
0.0022
2,4-dinitrophenyl-GPRFW-OH
-
pH 6.0, 37°C
0.0066
2,4-dinitrophenyl-GRRFW-OH
-
pH 6.0, 37°C
0.0038
2,4-dinitrophenyl-GSRFW-OH
-
pH 6.0, 37°C
0.0023
2,4-dinitrophenyl-GVRFW-OH
-
pH 6.0, 37°C
0.0011
2,4-dinitrophenyl-GYRFW-OH
-
pH 6.0, 37°C
0.004
4-(4-dimethylaminophenylazo)benzoyl-IEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
pH 4.5
0.0028 - 0.0036
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0035 - 0.0053
4-(4-dimethylaminophenylazo)benzoyl-L-Arg-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0046 - 0.0078
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-D-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0037 - 0.0082
4-(4-dimethylaminophenylazo)benzoyl-L-Leu-L-Arg-Gly-L-Phe-L-Glu-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0056
4-(4-dimethylaminophenylazo)benzoyl-LEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
pH 4.5
0.006 - 0.0066
4-(4-dimethylaminophenylazo)benzoyl-LRGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0035
4-(4-dimethylaminophenylazo)benzoyl-R-LVGFE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
pH 5.0
0.0037 - 0.0046
4-(4-dimethylaminophenylazo)benzoyl-RIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0055
4-(4-dimethylaminophenylazo)benzoyl-RIIEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
pH 4.5
0.0034 - 0.0049
4-(4-dimethylaminophenylazo)benzoyl-RLEGIE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.001 - 0.0038
4-(4-dimethylaminophenylazo)benzoyl-RLVG-beta-(2-naphthyl)alanine-E-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0029 - 0.0059
4-(4-dimethylaminophenylazo)benzoyl-RLVGF-L-alpha-aminoadipic acid-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.003 - 0.0145
4-(4-dimethylaminophenylazo)benzoyl-RLVGFD-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0022
4-(4-dimethylaminophenylazo)benzoyl-RLVGFE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
-
pH 6.0
0.0047 - 0.0078
4-(4-dimethylaminophenylazo)benzoyl-RLVGWE-5-[(2-aminoethyl)amino]naphthalene-1-sulfonic acid
0.0021
Abz-FF-3-dinitrophenyl-2,3-diaminopropionic acid-W-OH
-
pH 6.0, 37°C
0.003
Abz-FR-3-dinitrophenyl-2,3-diaminopropionic acid-W-OH
-
pH 6.0, 37°C
0.0177
Abz-FR-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-P-OH
-
pH 6.0, 37°C
0.0038
Abz-FR-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-W-OH
-
pH 6.0, 37°C
0.0179
Abz-FRA-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-OH
-
pH 6.0, 37°C
0.0014
Abz-FRF(NO2)A
37°C, pH 4.5
0.0328
Abz-FRF-epsilon-dinitrophenyl-L-lysyl-2,3-diaminopropionic acid-OH
-
pH 6.0, 37°C
0.0059
Abz-GIVRAK(Dnp)-OH
200 mM NaCl, 2.5 mM DTT, pH 4.5, 37°C
0.0008
Abz-GIVRAK-Dnp
37°C, pH 4.5
0.247
acetyl-F-R-4-methylcoumarin-7-amide
-
pH 6.0
0.4
acetyl-L-Arg-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.056
acetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
1.02 - 2
alpha-N-benzoyl-DL-Arg-beta-naphthylamide
0.05
Arg-4-methylcoumaryl-7-amide
-
-
0.51 - 24
benzoyl-DL-Arg-beta-naphthylamide
0.685 - 20
benzoyl-DL-Arg-p-nitroanilide
0.039
benzoyl-L-3-pyridyl-Ala-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.015
benzoyl-L-4-aminocyclohexyl-Ala-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.032
benzoyl-L-4-aminomethyl-N-isopropyl-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.019
benzoyl-L-4-aminomethyl-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.023
benzoyl-L-4-guanidine-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.052
benzoyl-L-4-piperidinyl-Ala-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.032
benzoyl-L-Arg-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.034
benzoyl-L-His-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.03
benzoyl-L-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.0232 - 0.18
benzoyl-Phe-Val-Arg-p-nitroanilide
0.2 - 1
benzoyl-Pro-Phe-Arg-p-nitroanilide
0.022 - 1.25
benzyloxycarbonyl-Ala-Arg-Arg-4-methoxy-beta-naphthylamide
0.02 - 0.29
benzyloxycarbonyl-Arg-Arg-4-methoxy-beta-naphthylamide
0.006 - 0.467
benzyloxycarbonyl-Arg-Arg-4-methylcoumaryl-7-amide
0.099 - 0.2622
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin
0.131
benzyloxycarbonyl-F-R-4-methylcoumarin-7-amide
-
pH 6.0
0.0287 - 0.0608
benzyloxycarbonyl-L-leucyl-L-arginine-4-methylcoumaryl-7-amide
0.0358 - 0.0656
benzyloxycarbonyl-L-phenylalaninyl-L-arginine 4-methylcoumaryl-7-amide
0.021 - 0.252
benzyloxycarbonyl-Phe-Arg-4-methylcoumaryl-7-amide
0.048
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 4.5
0.012 - 0.91
benzyloxycarbonyl-Val-Lys-Lys-Arg-4-methoxy-beta-naphthylamide
1.16
Boc-Asp-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.35
Boc-Asp-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.3
Boc-L-Leu-L-Lys-L-Arg-4-methylcoumaryl-7-amide
-
22°C, value is quite stable in the range of pH 4.0 to pH 7.8
1.67
Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.53
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.055
carbobenzoxy-Phe-Arg-7-amido-4-methylcoumarin
-
pH 6.5, recombinant enzyme
1.2
Cbz-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin
-
in 100 mM Na2HPO4, 1.25 mM EDTA., pH 6.8, at 25°C
0.13
D-Pro-Phe-Arg-p-nitroanilide
-
-
4.53
D-Val-Leu-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.089
epsilon-aminocaproic acid-L-Leu-Gly-4-methylcoumarin-7-amide
-
pH 6.0
0.0029
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)serine-4-methylcoumarin-7-amide
-
pH 6.0
0.0029
epsilon-aminocaproic acid-L-Leu-L-(O-benzyl)threonine-4-methylcoumarin-7-amide
-
pH 6.0
0.047
epsilon-aminocaproic acid-L-Leu-L-(O-methyl)-tyrosine-4-methylcoumarin-7-amide
-
pH 6.0
0.01
epsilon-aminocaproic acid-L-Leu-L-(S-benzyl)cysteine-4-methylcoumarin-7-amide
-
pH 6.0
0.034
epsilon-aminocaproic acid-L-Leu-L-Phe-4-methylcoumarin-7-amide
-
pH 6.0
0.055
epsilon-aminocaproic acid-L-R-4-methylcoumarin-7-amide
-
pH 6.0
0.00143 - 0.00217
hemoglobin
-
0.00288
N,N'-diBoc-dityrosine-Gly-(isoniazid)2
pH 6.2, 25°C
0.00201
N,N'-diBoc-dityrosine-Lys-(isoniazid)2
pH 6.2, 25°C
0.1
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
1.22
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.047
N-benzyloxycarbonyl-Phe-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.19
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.007
N-benzyloxycarbonyl-Val-Ile-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.072
N-t-butyloxycarbonyl-Gln-p-nitrophenyl ester
-
isoenzyme I and isoenzyme II
0.212 - 0.226
Nalpha-benzoyl-Arg-Arg-7-amido-4-methylcoumarin
0.043 - 0.075
Nalpha-benzoyl-Phe-Arg-7-amido-4-methylcoumarin
0.00611
Nalpha-carbobenzoxy-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin
recombinant enzyme, at pH 7.3 and 37°C
0.008
o-aminobenzoic acid-L-Lys-L-Leu-Gly-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.017
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)serine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.015
o-aminobenzoic acid-L-Lys-L-Leu-L-(O-benzyl)threonine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.019
o-aminobenzoic acid-L-Lys-L-Leu-L-(S-benzyl)cysteine-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.024
o-aminobenzoic acid-L-Lys-L-Leu-L-Arg-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.033
o-aminobenzoic acid-L-Lys-L-Leu-L-Phe-L-Phe-L-Ser-L-Lys-L-Gln-2,4-dinitrophenyl-ethylenediamine
-
pH 6.0
0.0125 - 0.047
o-aminobenzoyl-L-Phe-L-Arg-L-Lys-epsilon-N-2,4-dinitrophenylamide
0.081
phenylacetyl-L-Arg-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.027
phenylacetyl-L-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.02
protamine
-
-
0.88
Tos-Gly-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
0.06
Tos-Gly-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.082
Z-L-Arg-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C
0.04068
Z-L-Phe-L-Arg 7-amido-4-methylcoumarin
pH and temperature not specified in the publication
0.023
Z-L-Phe-L-Arg-4-methylcoumarin-7-amide
-
pH 6.0, 37°C