3.4.22.1: cathepsin B
This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.
Word Map on EC 3.4.22.1
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3.4.22.1
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cathepsins
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lysosomal
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proteinases
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papain
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collagen
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metastasis
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pancreatic
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cystatins
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procathepsin
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upa
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exopeptidase
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food industry
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myofibrillar
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mansoni
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schistosoma
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lc3-ii
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calpains
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permeabilization
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zymogen
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intralysosomal
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leupeptin
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peptidase
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hyperamylasemia
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pharmacology
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papain-like
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diagnostics
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biotechnology
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collagenase
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antibody-drug
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autophagy-lysosome
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pepstatin
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acinar
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ficin
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plasminogen
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caspase-1
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proenzyme
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legumain
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autophagosomes
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elastase
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caerulein
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caerulein-induced
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molecular biology
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dipeptidyl
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fluorogenic
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inflammasome
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endosomes
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pro-il-1
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supramaximal
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l-like
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b-mediated
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fasciola
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mu-calpain
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medicine
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trypsinogen
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hepatica
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drug development
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collagenolytic
- 3.4.22.1
- cathepsins
- lysosomal
- proteinases
- papain
- collagen
- metastasis
- pancreatic
- cystatins
-
procathepsin
- upa
-
exopeptidase
- food industry
- myofibrillar
- mansoni
- schistosoma
-
lc3-ii
- calpains
-
permeabilization
- zymogen
-
intralysosomal
- leupeptin
- peptidase
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hyperamylasemia
- pharmacology
-
papain-like
- diagnostics
- biotechnology
- collagenase
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antibody-drug
-
autophagy-lysosome
- pepstatin
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acinar
- ficin
- plasminogen
- caspase-1
- proenzyme
- legumain
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autophagosomes
- elastase
- caerulein
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caerulein-induced
- molecular biology
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dipeptidyl
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fluorogenic
- inflammasome
- endosomes
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pro-il-1
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supramaximal
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l-like
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b-mediated
- fasciola
- mu-calpain
- medicine
- trypsinogen
- hepatica
- drug development
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collagenolytic
Reaction
Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =
Synonyms
AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2
ECTree
3.4.22.1 cathepsin BAdvanced search results
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APPLICATION 
ORGANISM
UNIPROT
COMMENTARY 
LITERATURE
biotechnology
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inhibition of cathepsin B greatly improves the developmental competence of bovine oocytes and increases the number of high-quality embryos
diagnostics
drug development
food industry
the gel strength of modori gel is increased by suppression of cathepsin B activity using CA-074. Cathepsin B may cause modori phenomenon. Therefore, our results suggest that natural cysteine protease inhibitor, such as oryzacystatin derived from rice may apply to surimi-based product processing of horse mackerel to improve the quality of thermal gels
medicine
molecular biology
N,N'-diBoc-dityrosine-Gly-(isoniazid)2 is a sensitive and selective assay of cathepsin B activity
pharmacology
additional information
diagnostics
CATB is a potent and independent prognostic marker for resectable pancreatic adenocarcinoma
diagnostics
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cathepsin B is a biologic marker reflecting the clinical state of inflammatory disease
diagnostics
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increased cathepsin-B expression is predictive of more aggressive tumour behaviour over time and can be regarded as an unfavourable and independent tumour marker for endometrial cancer patients with a long follow-up
diagnostics
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cathepsin B is a possible prognostic biomarker for the aggressiveness of ovarian cancer, overview
diagnostics
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cathepsin B is an important biomarker for the stratification of glioblastoma patients with respect to survival
drug development
cathepsin B contributes to the neovascularization process and should be considered as a potential therapeutic target
drug development
peptides containing Ala or Phe at positions 6 are good substrates for the enzyme at both pH 5.0 and 7.4. Those containing Glu, Asp, Lys or Val are not cleaved at all by cathepsin B at pH 7.4 and are poorly hydrolized at pH 5.0. These findings provide new information for the rational design of cathepsin B-activated peptide-containing anticancer drugs
drug development
the new organotellurium(IV)compounds are powerful inhibitors of cathepsin B, constituting promising potential anti-metastatic agents
drug development
cathepsin B could be a drug target for several pathologies, based mainly on its role in cancer progression and osteoarthritis in humans
drug development
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cathepsin B is a target for anticancer metallodrugs, inhibition of cathepsin B by antitumor ruthenium(II)-arene compounds, overview
drug development
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cathepsin B is a possible therapeutic target for the control of tumor progression
drug development
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cathepsin B is a target for development of efficient and specific inhibitors
drug development
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cathepsin B is a target for development of inhibitors to lower amyloid-beta protein in Alzheimer's disease
drug development
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the enzyme is a target for therapeutic inhibitors or vaccination
drug development
cathepsin B is a target for anti-cancer therapy. RNA interference oligonucleotide shRNA-CTSB2 is the most efficient inhibition of cathepsin B at both mRNA and protein levels and results in suppressing endometrial cancer growth and development in vivo
drug development
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cathepsin B is a target for development of inhibitors to lower amyloid-beta protein in Alzheimer's disease
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medicine
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accumulation of undegraded macromolecules in lysosomes after oxidative damage are caused in part by direct protease inactivation by adduct formation with lipid peroxidation products
medicine
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enzyme is involved in neuronal cell death, particularly following ischemia
medicine
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enzyme is involved in neuronal cell death, particularly following ischemia
medicine
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involvement of cathepsins in the diminution of the lung antiprotease screen possibly leading to lung destruction in emphysema
medicine
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cathepsin B inhibitors are effective therapeutic agents in treatment of Alzheimer's disease reducing the amyloid beta plaque load in brain regions by up to 55%, reducing the formation of amyloid beta 40 and amyloid beta 42 by 45% and 40%, and improving the memory function, overview
medicine
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cathepsin B inhibitors are expected to be useful for the treatment of inflammatory joint disease, invasion of cancer, and other diseases related to cathepsin B disorder
medicine
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inhibition of cathepsins B and L may provide a unique mechanism for selectively inducing death of neuroblastoma with limited toxicity to normal cells and tissues
medicine
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pharmacologic modulation of cathepsin activity diminishes reovirus disease severity
medicine
cathepsin B is a target for anti-cancer therapy. RNA interference oligonucleotide shRNA-CTSB2 is the most efficient inhibition of cathepsin B at both mRNA and protein levels and results in suppressing endometrial cancer growth and development in vivo
medicine
engineering of a mouse T7 trypsinogen mutant (D22A,K24G), which is robustly activated by cathepsin B but cannot undergo autoactivation. These studies set the stage for the generation of a preclinical mouse model of CTSB-dependent pancreatitis
medicine
the control of cathepsin B expression may be a target for the treatment of metabolic disorders associated to an inflammatory background
medicine
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the enzyme has good antigenicity, and elicits high protection in Trichinella-infected mice, especially in the intestinal stage, a key stage for controlling infection. Therefore, TsCPB2 might be a promising vaccine candidate for controlling trichinellosis
medicine
the enzyme is involved in tumour progression and represents a potential therapeutic target in cancer
medicine
three dimensional structure of cathepsin B from Hordeum vulgare is predicted by using a homology modeling technique. The sequence and structure analysis reveal that the active site residues of cathepsin B from Hordeum vulgare are exactly the same to human cathepsin B. Probable involvement in the cleavage of amyloid beta peptide. Hence, the structure of cathepsin B from Hordeum vulgare can be useful to study Abeta peptide degradation in detail at the atomic level. Thus, this study might be useful to understand amyloid beta peptide degradation as well as to design alternative strategies to control Alzheimer's disease
medicine
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pharmacologic modulation of cathepsin activity diminishes reovirus disease severity
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medicine
Trichinella spiralis ISS 533
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the enzyme has good antigenicity, and elicits high protection in Trichinella-infected mice, especially in the intestinal stage, a key stage for controlling infection. Therefore, TsCPB2 might be a promising vaccine candidate for controlling trichinellosis
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pharmacology
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the cathepsin B cleavable spacer Phe-Lys-4-aminobenzyloxycarbonyl, incorporated in an albumin-binding prodrug, is an effective way to increase the therapeutic index of doxorubicin
pharmacology
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use of benzyloxycarbonyl-L-phenylalanyl-alanine-fluoromethylketone for inhibition of cathepsin-B seems a viable therapeutic strategy in TNF-alpha-mediated acute lung damage
pharmacology
Nicotiana benthamiana has recently emerged as a versatile expression platform for the rapid generation of recombinant biopharmaceuticals, but product yield and quality frequently suffer from unintended proteolysis. Targeted downregulation of cathepsin B can improve the performance of this plant-based expression platform
additional information
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cathepsin B is a marker for malignant diseases such as colorectal cancer, diagnostic accuracy, overview
additional information
the purified AC-5 is usel for vaccination of lambs against Haemonchus contortus infection
additional information
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the purified AC-5 is usel for vaccination of lambs against Haemonchus contortus infection
