Reference on EC 3.4.22.1 - cathepsin B
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REF. 
AUTHORS
TITLE
JOURNAL
VOL.
PAGES
YEAR
ORGANISM (UNIPROT)
PUBMED ID
SOURCE
Maciewicz, R.A.; Etherington, D.J.
A comparison of four cathepsins (B, L, N and S) with collagenolytic activity from rabbit spleen
Biochem. J.
256
433-440
1988
Oryctolagus cuniculus
Okitani, A.; Matsuishi, M.; Matsumoto, T.; Kamoshida, E.; Sato, M.; Matsukura, U.; Watanabe, M.; Kato, H.; Fujimaki, M.
Purification and some properties of cathepsin B from rabbit skeletal muscle
Eur. J. Biochem.
171
377-381
1988
Oryctolagus cuniculus
Brzin, J.; Popovic, T.; Drobnic-Kosorok, M.; Kotnik, M.; Turk, V.
Inhibitors of cysteine proteinases from potato
Biol. Chem. Hoppe-Seyler
369
233-238
1988
Homo sapiens
Buttle, D.J.; Bonner, B.C.; Burnett, D.; Barrett, A.J.
A catalytically active high-Mr form of human cathepsin B from sputum
Biochem. J.
254
693-699
1988
Homo sapiens
Wada, K.; Tanabe, T.
Purification and characterization of chicken liver cathepsin B
J. Biochem.
104
472-476
1988
Gallus gallus
Aranishi, F.; Hara, K.; Osatomi, K.; Ishihara, T.
Purification and immunological properties of cathepsin B in carp Cyprinus carpio
Comp. Biochem. Physiol. B
114
371-376
1996
Cyprinus carpio
-
Okada, Y.; Yokota, Y.
Purification and properties of cathepsin B from sea urchin eggs
Comp. Biochem. Physiol. B
96
381-386
1990
Heliocidaris crassispina, Hemicentrotus pulcherrimus
-
Aranishi, F.; Hara, K.; Osatomi, K.; Ishihara, T.
Purification and characterization of cathepsin B from hepatopancreas of carp Cyprinus carpio
Comp. Biochem. Physiol. B
117
579-587
1997
Cyprinus carpio
-
Spizz, G.; Blackshear, P.J.
Identification and characterization of cathepsin B as the cellular MARCKS cleaving enzyme
J. Biol. Chem.
272
23833-23842
1997
Bos taurus
Harrop, S.A.; Sawangjaroen, N.; Prociv, P.; Brindley, P.J.
Characterization and localization of cathepsin B proteinases expressed by adult Ancylostoma caninum hookworms
Mol. Biochem. Parasitol.
71
163-171
1995
Ancylostoma caninum
Baricos, W.H.; Zhou, Y.; Mason, R.W.; Barrett, A.J.
Human kidney cathepsins B and L. Characterization and potential role in degradation of glomerular basement membrane
Biochem. J.
252
301-304
1988
Homo sapiens
Fazili, K.M.; Qasim, M.A.
Purification and some properties of buffalo liver cathepsin B
J. Biochem.
100
293-299
1986
Bubalus bubalis
Takahashi, T.; Yonezawa, S.; Dehdarani, A.H.; Tang, J.
Comparative studies of two cathepsin B isozymes from porcine spleen. Isolation, polypeptide chain arrangements, and enzyme specificity
J. Biol. Chem.
261
9368-9374
1986
Sus scrofa
Simon, J.; Duffy, M.J.
Characterization of a cathepsin B-like enzyme from breast cancer
Biochem. Soc. Trans.
14
460
1986
Homo sapiens
-
Rich, D.H.; Brown, M.A.; Barrett, A.J.
Purification of cathepsin B by a new form of affinity chromatography
Biochem. J.
235
731-734
1986
Homo sapiens
Erikson-Viitanen, S.; Balestreri, E.; McDermott, M.J.; Horecker, B.L.; Melloni, E.; Pontremoli, S.
Purification and properties of rabbit liver cathepsin M and cathepsin B
Arch. Biochem. Biophys.
243
46-61
1985
Oryctolagus cuniculus
Hirao, T.; Hara, K.; Takahashi, K.
Purification and characterization of cathepsin B from monkey skeletal muscle
J. Biochem.
95
871-879
1984
Macaca fuscata
Olstein, A.D.; Liener, I.E.
Comparative studies of mouse liver cathepsin B and an analogous tumor thiol proteinase
J. Biol. Chem.
258
11049-11056
1983
Mus musculus
Banno, Y.; Yano, K.; Nozawa, Y.
Purification and characterization of a secreted protease from Tetrahymena pyriformis
Eur. J. Biochem.
132
563-568
1983
Tetrahymena pyriformis
Gounaris, A.D.; Slater, E.E.
Cathepsin B from human renal cortex
Biochem. J.
205
295-302
1982
Homo sapiens
Perona, R.; Vallejo, C.G.
The lysosomal proteinase of Artemia. Purification and characterization
Eur. J. Biochem.
124
357-362
1982
Artemia sp.
Barrett, A.J.; Kirschke, H.
Cathepsin B, Cathepsin H, and cathepsin L
Methods Enzymol.
80
535-561
1981
Homo sapiens
Takahashi, S.; Murakami, K.; Miyake, Y.
Purification and characterization or porcine kidney cathepsin B
J. Biochem.
90
1677-1684
1981
Sus scrofa
Towatari, T.; Kawabata, Y.; Katunuma, N.
Crystallization and properties of cathepsin B from rat liver
Eur. J. Biochem.
102
279-289
1979
Rattus norvegicus
Lenney, J.F.; Tolan, J.R.; Sugai, W.J.; Lee, A.G.
Thermostable endogenous inhibitors of cathepsins B and H
Eur. J. Biochem.
101
153-161
1979
Rattus norvegicus
Suhar, A.; Marks, N.
Purification and properties of brain cathepsin B. Evidence for cleavage of pituitary lipotropins
Eur. J. Biochem.
101
23-30
1979
Bos taurus
MacGregor, R.R.; Hamilton, J.W.; Shofstall, R.E.; Cohn, D.V.
Isolation and characterization of porcine parathyroid cathepsin B
J. Biol. Chem.
254
4423-4427
1979
Sus scrofa
Takahashi, K.; Isemura, M.; Ikenaka, R.
Isolation and characterization of three forms of cathepsin B from porcine liver
J. Biochem.
85
1053-1060
1979
Sus scrofa
Evans, P.; Etherington, D.J.
Characterisation of cathepsin B and collagenolytic cathepsin from human placenta
Eur. J. Biochem.
83
87-97
1978
Homo sapiens
Szego, C.M.; Seeler, B.J.; Smith, R.E.
Lysosomal cathepsin B1: Partial characterization in rat preputial gland and recompartmentation in response to estradiol-17beta
Eur. J. Biochem.
69
463-474
1976
Rattus norvegicus
-
Inaba, T.; Shindo, N.; Fujii, M.
Purification of cathepsin B from squid liver
Agric. Biol. Chem.
40
1159-1165
1976
Dorytheuthis bleekeri
-
Etherington, D.J.
Bovine spleen cathepsin B1 and collagenolytic cathepsin. A comparative study of the properties of the two enzymes in the degradation of native collagen
Biochem. J.
153
199-209
1976
Bos taurus
Otto, K.; Riesenknig, H.
Improved purification of cathepsin B1 and cathepsin B2
Biochim. Biophys. Acta
379
462-475
1975
Bos taurus
Ogino, K.; Nakashima, K.
Purification of rabbit liver cathepsin B1
J. Biochem.
75
723-730
1974
Oryctolagus cuniculus
Swanson, A.A.; Martin, B.J.; Spicer, S.S.
Human placental cathepsin B1. Isolation and some physical properties
Biochem. J.
137
223-228
1974
Homo sapiens
Watanabe, H.; Green, G.D.J.; Shaw, E.
A comparison of the behavior of chymotrypsin and cathepsin B towards peptidyl diazomethyl ketones
Biochem. Biophys. Res. Commun.
89
1354-1360
1979
Bos taurus
Wilson, L.R.; Good, R.T.; Panaccio, M.; Wijffels, G.L.; Sandeman, R.M.; Spithill, T.W.
Fasciola hepatica: characterization and cloning of the major cathepsin B protease secreted by newly excysted juvenile liver fluke
Exp. Parasitol.
88
85-94
1998
Fasciola hepatica
Musil, D.; Zucic, D.; Engh, R.A.; Mayr, I.; Huber, R.; Popovic, T.; Turk, V.; Towatari, T.; Katanuma, N.; Bode, W.
The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity
EMBO J.
10
2321-2330
1991
Homo sapiens
Kamboj, R.C.; Pal, S.; Singh, H.
Purification and characterization of cathepsin B from goat brain
J. Biosci.
15
397-408
1990
Capra hircus
-
Agarwal, S.K.; Choudhury, S.D.; lamsal, M.; Khan, M.Y.
Catalytic and physico-chemical characteristics of goat spleen cathepsin B
Biochem. Mol. Biol. Int.
42
1215-1226
1997
Capra hircus
Jiang, S.T.; Lee, J.J.; Chen, H.C.
Purification and characterization of cathepsin B from ordinary muscle of mackerel (Scomber australasicus)
J. Agric. Food Chem.
42
1073-1079
1999
Scomber australasicus
-
Deval, C.; Bechet, D.; Obled, A.; Ferrara, M.
Purification and properties of different isoforms of bovine cathepsin B
Biochem. Cell Biol.
68
822-826
1990
Bos taurus
Kawada, A.; Hara, K.; Morimoto, K.; Hiruma, M.; Ishibashi, A.
Rat epidermal cathepsin B: purification and characterization of proteolytic properties toward filaggrin and synthetic substrates
Int. J. Biochem. Cell Biol.
27
175-183
1995
Rattus norvegicus
Ahmad, S.; Agarwal, S.K.; Khan, M.Y.
Purification and some properties of bufffalo spleen cathepsin B
J. Biosci.
14
261-268
1989
Bubalus bubalis
-
Ahmad, S.; Khan, M.Y.
Further characterization of buffalo spleen cathepsin B
Biochem. Int.
22
951-958
1990
Bubalus bubalis
Lamsal, M.; Agarwal, S.K.; Choudhury, S.D.; Khan, M.Y.
Purification and tissue/species dependence of the specificity of buffalo kidney cathepsin B
Indian J. Biochem. Biophys.
34
461-469
1997
Bubalus bubalis
Ghoneim, H.; Klinkert, M.Q.
Biochemical properties of purified cathepsin B from Schistosoma mansoni
Int. J. Parasitol.
25
1515-1519
1995
Schistosoma mansoni
Salahuddin, A.; Siddiqui, F.A.; Salahuddin, P.
Isolation, purification and properties of cathepsin B from buffalo liver
Indian J. Biochem. Biophys.
33
292-297
1996
Bubalus bubalis
San Segundo, B.; Chan, S.J.; Steiner, D.F.
Identification of cDNA clones encoding a precursor of rat liver cathepsin B
Proc. Natl. Acad. Sci. USA
82
2320-2324
1985
Rattus norvegicus
Chan, S.J; San Segundo, B.; McCormick, M.B.; Steiner, D.
Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs
Proc. Natl. Acad. Sci. USA
83
7721-7725
1986
Homo sapiens, Mus musculus
Jia, Z.; Hasnain, S.; Hirama, T.; Lee, X.; Mort, J.S.; To, R.
Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design [published erratum appears in J Biol Chem 1995 Nov 24;270(47):28494
J. Biol. Chem.
270
5527-5533
1995
Rattus norvegicus
Lee, X.; Ahmed, F.R.; Hirama, T.; Huber, C.P.; Rose, D.R.; To, R.; Hasnain, S.
Crystallization of recombinant rat cathepsin B
J. Biol. Chem.
265
5950-5951
1990
Rattus norvegicus
Steed, P.M.; Lasala, D.; Liebman, J.; Wigg, A.; Clark, K.; Knap, A.K.
Characterization of recombinant human cathepsin B expressed at high levels in baculovirus
Protein Sci.
7
2033-2037
1998
Homo sapiens
Hasnain, S.; Hirama, T.; Huber, C.P.; Mason, P.; Mort, J.S.
Characterization of cathepsin B specificity by site-directed mutagenesis. Importance of Glu245 in the S2-P2 specificity for arginine and its role in transition state stabilization
J. Biol. Chem.
268
235-240
1993
Rattus norvegicus
Taniguchi, T.; Mizuochi, T.; Towatari, T.; Katunuma, N.; Kobata, A.
Structural studies on the carbohydrate moieties of rat liver cathepsins B and H
J. Biochem.
97
973-976
1985
Rattus norvegicus
Quraishi, O.; Storer, A.C.
Identification of internal autoproteolytic cleavage sites within the prosegments of recombinant procathepsin B and procathepsin S. Contribution of a plausible unimolecular autoproteolytic event for the processing of zymogens belonging to the papain family
J. Biol. Chem.
276
8118-8124
2001
Homo sapiens
Stachowiak, K.; Tokmina, M.; Karpinska, A.; Sosnowska, R.; Wiczk, W.
Fluorogenic peptide substrates for carboxydipeptidase activity of cathepsin B
Acta Biochim. Pol.
51
81-92
2004
Bos taurus
Jane, D.T.; Morvay, L.C.; Allen, F.; Sloane, B.F.; Dufresne, M.J.
Selective inhibition of cathepsin B with cell-permeable CA074me negatively affects L6 rat myoblast differentiation
Biochem. Cell Biol.
80
457-465
2002
Rattus norvegicus
Sentandreu, M.A.; Aubry, L.; Ouali, A.
Purification of bovine cathepsin B: Proteomic characterization of the different forms and production of specific antibodies
Biochem. Cell Biol.
81
317-326
2003
Bos taurus
Krupa, J.C.; Hasnain, S.; Nagler, D.K.; Menard, R.; Mort, J.S.
S2' substrate specificity and the role of His110 and His111 in the exopeptidase activity of human cathepsin B
Biochem. J.
361
613-619
2002
Homo sapiens (P07858), Homo sapiens
Cezari, M.H.; Puzer, L.; Juliano, M.A.; Carmona, A.K.; Juliano, L.
Cathepsin B carboxydipeptidase specificity analysis using internally quenched fluorescent peptides
Biochem. J.
368
365-369
2002
Homo sapiens
Therrien, C.; Lachance, P.; Sulea, T.; Purisima, E.O.; Qi, H.; Ziomek, E.; Alvarez-Hernandez, A.; Roush, W.R.; Menard, R.
Cathepsins X and B can be differentiated through their respective mono- and dipeptidyl carboxypeptidase activities
Biochemistry
40
2702-2711
2001
Homo sapiens (P07858)
Melo, R.L.; Barbosa Pozzo, R.C.; Alves, L.C.; Perissutti, E.; Caliendo, G.; Santagada, V.; Juliano, L.; Juliano, M.A.
Synthesis and hydrolysis by cathepsin B of fluorogenic substrates with the general structure benzoyl-X-ARG-MCA containing non-natural basic amino acids at position X
Biochim. Biophys. Acta
1547
82-94
2001
Homo sapiens
Yamamoto, A.; Tomoo, K.; Matsugi, K.; Hara, T.; In, Y.; Murata, M.; Kitamura, K.; Ishida, T.
Structural basis for development of cathepsin B-specific noncovalent-type inhibitor: crystal structure of cathepsin B-E64c complex
Biochim. Biophys. Acta
1597
244-251
2002
Bos taurus
Menard, R.; Therrien, C.; Lachance, P.; Sulea, T.; Qi, H.; Alvarez-Hernandez, A.; Roush, W.R.
Cathepsins X and B display distinct activity profiles that can be exploited for inhibitor design
Biol. Chem.
382
839-845
2001
Homo sapiens
Pillay, C.S.; Dennison, C.
Cathepsin B stability, but not activity, is affected in cysteine:cystine redox buffers
Biol. Chem.
383
1199-1204
2002
Bos taurus
Schaschke, N.; Deluca, D.; Assfalg-Machleidt, I.; Hohneke, C.; Sommerhoff, C.P.; Machleidt, W.
Epoxysuccinyl peptide-derived cathepsin B inhibitors: modulating membrane permeability by conjugation with the C-terminal heptapeptide segment of penetratin
Biol. Chem.
383
849-852
2002
Homo sapiens
Nakagomi, K.; Fujimura, A.; Maeda, H.; Sadakane, Y.; Fujii, N.; Akizawa, T.; Tanimura, T.; Hatanaka, Y.
Isolation of novel peptides, cabin-1, -2, -3, and -4, that inhibit cathepsin B from a thermolysin digest of human plasma
Biol. Pharm. Bull.
25
564-568
2002
Homo sapiens
Cathers, B.E.; Barrett, C.; Palmer, J.T.; Rydzewski, R.M.
pH Dependence of inhibitors targeting the occluding loop of cathepsin B
Bioorg. Chem.
30
264-275
2002
Homo sapiens
Aoki, H.; Ahsan, M.N.; Watabe, S.
Molecular cloning and characterization of cathepsin B from the hepatopancreas of northern shrimp Pandalus borealis
Comp. Biochem. Physiol. B
134
681-694
2003
Pandalus borealis
Matsuishi, M.; Okitani, A.
Purification and properties of cysteine proteinase inhibitors from rabbit skeletal muscle
Comp. Biochem. Physiol. B
136B
309-316
2003
Oryctolagus cuniculus
-
Song, J.; Xu, P.; Xiang, H.; Su, Z.; Storer, A.C.; Ni, F.
The active-site residue Cys-29 is responsible for the neutral-pH inactivation and the refolding barrier of human cathepsin B
FEBS Lett.
475
157-162
2000
Homo sapiens
Yamamoto, A.; Tomoo, K.; Hara, T.; Murata, M.; Kitamura, K.; Ishida, T.
Substrate specificity of bovine cathepsin B and its inhibition by CA074, based on crystal structure refinement of the complex
J. Biochem.
127
635-643
2000
Bos taurus
Gray, J.; Haran, M.M.; Schneider, K.; Vesce, S.; Ray, A.M.; Owen, D.; White, I.R.; Cutler, P.; Davis, J.B.
Evidence that inhibition of cathepsin-B contributes to the neuroprotective properties of caspase inhibitor Tyr-Val-Ala-Asp-chloromethyl ketone
J. Biol. Chem.
276
32750-32755
2001
Mus musculus, Rattus norvegicus
Taggart, C.C.; Lowe, G.J.; Greene, C.M.; Mulgrew, A.T.; O'Neill, S.J.; Levine, R.L.; McElvaney, N.G.
Cathepsin B, L, and S cleave and inactivate secretory leucoprotease inhibitor
J. Biol. Chem.
276
33345-33352
2001
Homo sapiens
Almeida, P.C.; Nantes, I.L.; Chagas, J.R.; Rizzi, C.C.; Faljoni-Alario, A.; Carmona, E.; Juliano, L.; Nader, H.B.; Tersariol, I.L.
Cathepsin B activity regulation. Heparin-like glycosaminogylcans protect human cathepsin B from alkaline pH-induced inactivation
J. Biol. Chem.
276
944-951
2001
Homo sapiens
Que, X.; Ngo, H.; Lawton, J.; Gray, M.; Liu, Q.; Engel, J.; Brinen, L.; Ghosh, P.; Joiner, K.A.; Reed, S.L.
The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing
J. Biol. Chem.
277
25791-25797
2002
Toxoplasma gondii
Greenspan, P.D.; Clark, K.L.; Tommasi, R.A.; Cowen, S.D.; McQuire, L.W.; Farley, D.L.; van Duzer, J.H.; Goldberg, R.L.; Zhou, H.; Du, Z.; Fitt, J.J.; Coppa, D.E.; Fang, Z.; Macchia, W.; Zhu, L.; Capparelli, M.P.; Goldstein, R.; Wigg, A.M.; Doughty, J.R.; Bohacek, R.S.; Knap, A.K.
Identification of dipeptidyl nitriles as potent and selective inhibitors of cathepsin B through structure-based drug design
J. Med. Chem.
44
4524-4534
2001
Homo sapiens
Del Nery, E.; Alves, L.C.; Melo, R.L.; Cesari, M.H.; Juliano, L.; Juliano, M.A.
Specificity of cathepsin B to fluorescent substrates containing benzyl side-chain-substituted amino acids at P1 subsite
J. Protein Chem.
19
33-38
2000
Homo sapiens
Lee, H.S.; Lee, K.J.
Cathepsin B inhibitory peptides derived from beta-casein
Peptides
21
807-809
2000
Rattus norvegicus
Nakagomi, K.; Takatsu, K.; Takagi, S.; Ebisu, H.; Sadakane, Y.; Fujii, N.; Akizawa, T.; Tanimura, T.; Hatanaka, Y.
Isolation of cathepsin B inhibitory peptides, Cabin-A1 and -A2, from a tryptic and chymotryptic hydrolysate of human serum albumin
Peptides
23
1567-1571
2002
Homo sapiens
Crabb, J.W.; O'Neil, J.; Miyagi, M.; West, K.; Hoff, H.F.
Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues
Protein Sci.
11
831-840
2002
Bos taurus
Lindkvist, B.; Fajardo, I.; Pejler, G.; Borgstrom, A.
Cathepsin B activates human trypsinogen 1 but not proelastase 2 or procarboxypeptidase B
Pancreatology
6
224-231
2006
Homo sapiens (P07858), Homo sapiens
Raldua, D.; Fabra, M.; Bozzo, M.G.; Weber, E.; Cerda, J.
Cathepsin B-mediated yolk protein degradation during killifish oocyte maturation is blocked by an H+-ATPase inhibitor: effects on the hydration mechanism
Am. J. Physiol. Regul. Integr. Comp. Physiol.
290
R456-R466
2006
Fundulus heteroclitus (Q6XPZ9)
Cotrin, S.S.; Puzer, L.; de Souza Judice, W.A.; Juliano, L.; Carmona, A.K.; Juliano, M.A.
Positional-scanning combinatorial libraries of fluorescence resonance energy transfer peptides to define substrate specificity of carboxydipeptidases: assays with human cathepsin B
Anal. Biochem.
335
244-252
2004
Homo sapiens (P07858), Homo sapiens
Gilmore, B.F.; Harriott, P.; Walker, B.
The inactivation of bovine cathepsin B by novel N-chloro-acetyl-dipeptides: application of the Houghten tea bag methodology to inhibitor synthesis
Biochem. Biophys. Res. Commun.
333
1284-1288
2005
Bos taurus (P07688), Bos taurus
Jane, D.T.; Morvay, L.; Dasilva, L.; Cavallo-Medved, D.; Sloane, B.F.; Dufresne, M.J.
Cathepsin B localizes to plasma membrane caveolae of differentiating myoblasts and is secreted in an active form at physiological pH
Biol. Chem.
387
223-234
2006
Rattus norvegicus (P00787)
Pan, X.; Tan, N.; Zeng, G.; Zhang, Y.; Jia, R.
Amentoflavone and its derivatives as novel natural inhibitors of human Cathepsin B
Bioorg. Med. Chem.
13
5819-5825
2005
Homo sapiens (P07858), Homo sapiens
Cunha, R.L.; Urano, M.E.; Chagas, J.R.; Almeida, P.C.; Bincoletto, C.; Tersariol, I.L.; Comasseto, J.V.
Tellurium-based cysteine protease inhibitors: evaluation of novel organotellurium(IV) compounds as inhibitors of human cathepsin B
Bioorg. Med. Chem. Lett.
15
755-760
2005
Homo sapiens (P07858), Homo sapiens
Lim, S.U.; Seo, J.S.; Kim, M.S.; Ahn, S.J.; Jeong, H.D.; Kim, K.H.; Park, N.G.; Kim, J.K.; Chung, J.K.; Lee, H.H.
Molecular cloning and characterization of cathepsin B from a scuticociliate, Uronema marinum
Comp. Biochem. Physiol. B Biochem. Mol. Biol.
142
283-292
2005
Uronema marinum (Q6SSE0), Uronema marinum
Frlan, R.; Gobec, S.
Inhibitors of cathepsin B
Curr. Med. Chem.
13
2309-2327
2006
Homo sapiens (P07858), Homo sapiens
Troy, A.M.; Sheahan, K.; Mulcahy, H.E.; Duffy, M.J.; Hyland, J.M.; ODonoghue, D.P.
Expression of cathepsin B and L antigen and activity is associated with early colorectal cancer progression
Eur. J. Cancer
40
1610-1616
2004
Homo sapiens (P07858), Homo sapiens
Zeng, G.Z.; Pan, X.L.; Tan, N.H.; Xiong, J.; Zhang, Y.M.
Natural biflavones as novel inhibitors of cathepsin B and K
Eur. J. Med. Chem.
41
1247-1552
2006
Homo sapiens (P07858), Homo sapiens
Ellis, R.C.; O'Steen, W.A.; Hayes, R.L.; Nick, H.S.; Wang, K.K.; Anderson, D.K.
Cellular localization and enzymatic activity of cathepsin B after spinal cord injury in the rat
Exp. Neurol.
193
19-28
2005
Rattus norvegicus (P00787)
Dvorak, J.; Delcroix, M.; Rossi, A.; Vopalensky, V.; Pospisek, M.; Sedinova, M.; Mikes, L.; Sajid, M.; Sali, A.; McKerrow, J.H.; Horak, P.; Caffrey, C.R.
Multiple cathepsin B isoforms in schistosomula of Trichobilharzia regenti: identification, characterisation and putative role in migration and nutrition
Int. J. Parasitol.
35
895-910
2005
Trichobilharzia regenti (Q4VRW4), Trichobilharzia regenti (Q4VRW5), Trichobilharzia regenti (Q4VRW6), Trichobilharzia regenti (Q4VRW7), Trichobilharzia regenti (Q4VRW8), Trichobilharzia regenti (Q4VRW9), Trichobilharzia regenti
Laurent-Matha, V.; Derocq, D.; Prebois, C.; Katunuma, N.; Liaudet-Coopman, E.
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
J. Biochem.
139
363-371
2006
Homo sapiens (P07858), Homo sapiens
Ebert, D.H.; Kopecky-Bromberg, S.A.; Dermody, T.S.
Cathepsin B is inhibited in mutant cells selected during persistent reovirus infection
J. Biol. Chem.
279
3837-3851
2004
Mus musculus (P10605), Mus musculus
Premzl, A.; Turk, V.; Kos, J.
Intracellular proteolytic activity of cathepsin B is associated with capillary-like tube formation by endothelial cells in vitro
J. Cell. Biochem.
97
1230-1240
2006
Homo sapiens (P07858), Homo sapiens
Wieczerzak, E.; Jankowska, E.; Rodziewicz-Motowidlo, S.; Gieldon, A.; Lagiewka, J.; Grzonka, Z.; Abrahamson, M.; Grubb, A.; Broemme, D.
Novel azapeptide inhibitors of cathepsins B and K. Structural background to increased specificity for cathepsin B
J. Pept. Res.
66 Suppl 1
1-11
2005
Homo sapiens (P07858)
Ruzza, P.; Quintieri, L.; Osler, A.; Calderan, A.; Biondi, B.; Floreani, M.; Guiotto, A.; Borin, G.
Fluorescent, internally quenched, peptides for exploring the pH-dependent substrate specificity of cathepsin B
J. Pept. Sci.
12
455-461
2006
Bos taurus (P07688)
Taha, T.A.; El-Alwani, M.; Hannun, Y.A.; Obeid, L.M.
Sphingosine kinase-1 is cleaved by cathepsin B in vitro: Identification of the initial cleavage sites for the protease
FEBS Lett.
580
6047-6054
2006
Homo sapiens
Raldua, D.; Fabra, M.; Bozzo, M.G.; Weber, E.; Cerda, J.
Cathepsin B-mediated yolk protein degradation during killifish oocyte maturation is blocked by an H+-ATPase inhibitor: effects on the hydration mechanism
Am. J. Physiol.
290
R456-R466
2006
Fundulus heteroclitus
Anagli, J.; Abounit, K.; Stemmer, P.; Han, Y.; Allred, L.; Weinsheimer, S.; Movsisyan, A.; Seyfried, D.
Effects of cathepsins B and L inhibition on postischemic protein alterations in the brain
Biochem. Biophys. Res. Commun.
366
86-91
2008
Rattus norvegicus (P00787)
Yakovlev, A.A.; Gorokhovatsky, A.Y.; Onufriev, M.V.; Beletsky, I.P.; Gulyaeva, N.V.
Brain cathepsin B cleaves a caspase substrate
Biochemistry (Moscow)
73
332-336
2008
Rattus norvegicus
Schmid, B.; Chung, D.E.; Warnecke, A.; Fichtner, I.; Kratz, F.
Albumin-binding prodrugs of camptothecin and doxorubicin with an Ala-Leu-Ala-Leu-linker that are cleaved by cathepsin B: synthesis and antitumor efficacy
Bioconjug. Chem.
18
702-716
2007
Homo sapiens
Serveau-Avesque, C.; Ferrer-Di Martino, M.; Herve-Grepinet, V.; Hazouard, E.; Gauthier, F.; Diot, E.; Lalmanach, G.
Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids
Biol. Cell.
98
15-22
2006
Homo sapiens
Myers, M.C.; Napper, A.D.; Motlekar, N.; Shah, P.P.; Chiu, C.H.; Beavers, M.P.; Diamond, S.L.; Huryn, D.M.; Smith, A.B.
Identification and characterization of 3-substituted pyrazolyl esters as alternate substrates for cathepsin B: the confounding effects of DTT and cysteine in biological assays
Bioorg. Med. Chem. Lett.
17
4761-4766
2007
Homo sapiens
Hoang, V.L.; Li, Y.; Kim, S.K.
Cathepsin B inhibitory activities of phthalates isolated from a marine Pseudomonas strain
Bioorg. Med. Chem. Lett.
18
2083-2088
2008
Homo sapiens
Fujisawa, A.; Kambe, N.; Saito, M.; Nishikomori, R.; Tanizaki, H.; Kanazawa, N.; Adachi, S.; Heike, T.; Sagara, J.; Suda, T.; Nakahata, T.; Miyachi, Y.
Disease-associated mutations in CIAS1 induce cathepsin B-dependent rapid cell death of human THP-1 monocytic cells
Blood
109
2903-2911
2007
Homo sapiens
Wang, Y.; Gu, Z.L.; Cao, Y.; Liang, Z.Q.; Han, R.; Bennett, M.C.; Qin, Z.H.
Lysosomal enzyme cathepsin B is involved in kainic acid-induced excitotoxicity in rat striatum
Brain Res.
1071
245-249
2006
Rattus norvegicus
Vasiljeva, O.; Papazoglou, A.; Krueger, A.; Brodoefel, H.; Korovin, M.; Deussing, J.; Augustin, N.; Nielsen, B.S.; Almholt, K.; Bogyo, M.; Peters, C.; Reinheckel, T.
Tumor cell-derived and macrophage-derived cathepsin B promotes progression and lung metastasis of mammary cancer
Cancer Res.
66
5242-5250
2006
Mus musculus
Sharma, S.; Mittal, A.; Gupta, V.K.; Singh, H.
Improved stabilization of microencapsulated cathepsin B in harsh conditions
Enzyme Microb. Technol.
40
337-342
2007
Capra aegagrus
-
Bueth, H.; Luigi Buttigieg, P.; Ostafe, R.; Rehders, M.; Dannenmann, S.R.; Schaschke, N.; Stark, H.J.; Boukamp, P.; Brix, K.
Cathepsin B is essential for regeneration of scratch-wounded normal human epidermal keratinocytes
Eur. J. Cell Biol.
86
747-761
2007
Homo sapiens
Tan, Y.; Osatomi, K.; Nozaki, Y.; Ishihara, T.; Hara, K.
Occurrence of two distinct molecular species of cathepsin B in carp Cyprinus carpio
Fish. Sci.
72
185-194
2006
Cyprinus carpio (Q3V5Y3)
-
Koo, Y.D.; Ahn, J.E.; Salzman, R.A.; Moon, J.; Chi, Y.H.; Yun, D.J.; Lee, S.Y.; Koiwa, H.; Zhu-Salzman, K.
Functional expression of an insect cathepsin B-like counter-defence protein
Insect Mol. Biol.
17
235-245
2008
Callosobruchus maculatus (B2XVS9), Callosobruchus maculatus (Q5VJM8), Callosobruchus maculatus
Sandes, E.; Lodillinsky, C.; Cwirenbaum, R.; Argueelles, C.; Casabe, A.; Eijan, A.M.
Cathepsin B is involved in the apoptosis intrinsic pathway induced by Bacillus Calmette-Guerin in transitional cancer cell lines
Int. J. Mol. Med.
20
823-828
2007
Homo sapiens
Gunatilleke, S.S.; de Oliveira, C.A.; McCammon, J.A.; Barrios, A.M.
Inhibition of cathepsin B by Au(I) complexes: a kinetic and computational study
J. Biol. Inorg. Chem.
13
555-561
2008
Homo sapiens
Nagaraj, N.S.; Vigneswaran, N.; Zacharias, W.
Cathepsin B mediates TRAIL-induced apoptosis in oral cancer cells
J. Cancer Res. Clin. Oncol.
132
171-183
2006
Homo sapiens
Dacks, J.B.; Kuru, T.; Liapounova, N.A.; Gedamu, L.
Phylogenetic and primary sequence characterization of cathepsin B cysteine proteases from the oxymonad flagellate Monocercomonoides
J. Eukaryot. Microbiol.
55
9-17
2008
Monocercomonoides sp.
Hasan, L.; Mazzucchelli, L.; Liebi, M.; Lis, M.; Hunger, R.E.; Tester, A.; Overall, C.M.; Wolf, M.
Function of liver activation-regulated chemokine/CC chemokine ligand 20 is differently affected by cathepsin B and cathepsin D processing
J. Immunol.
176
6512-6522
2006
Homo sapiens
Gunatilleke, S.S.; Barrios, A.M.
Tuning the Au(I)-mediated inhibition of cathepsin B through ligand substitutions
J. Inorg. Biochem.
102
555-563
2008
Homo sapiens
Watanabe, D.; Yamamoto, A.; Tomoo, K.; Matsumoto, K.; Murata, M.; Kitamura, K.; Ishida, T.
Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes
J. Mol. Biol.
362
979-993
2006
Bos taurus
Link, M.A.; Silva, L.A.; Schaffer, P.A.
Cathepsin B mediates cleavage of herpes simplex virus type 1 origin binding protein (OBP) to yield OBPC-1, and cleavage is dependent upon viral DNA replication
J. Virol.
81
9175-9182
2007
Homo sapiens (P07858)
Gilroy, E.M.; Hein, I.; van der Hoorn, R.; Boevink, P.C.; Venter, E.; McLellan, H.; Kaffarnik, F.; Hrubikova, K.; Shaw, J.; Holeva, M.; Lopez, E.C.; Borras-Hidalgo, O.; Pritchard, L.; Loake, G.J.; Lacomme, C.; Birch, P.R.
Involvement of cathepsin B in the plant disease resistance hypersensitive response
Plant J.
52
1-13
2007
Nicotiana benthamiana (Q1HER6)
Krautz-Peterson, G.; Skelly, P.J.
Schistosome asparaginyl endopeptidase (legumain) is not essential for cathepsin B1 activation in vivo
Mol. Biochem. Parasitol.
159
54-58
2008
Schistosoma mansoni
Rhee, S.H.; Kang, J.; Nahm, D.S.
Cystatins and cathepsin B during orthodontic tooth movement
Am. J. Orthod. Dentofacial. Orthop.
135
99-105
2009
Homo sapiens
Hamer, I.; Delaive, E.; Dieu, M.; Abdel-Sater, F.; Mercy, L.; Jadot, M.; Arnould, T.
Up-regulation of cathepsin B expression and enhanced secretion in mitochondrial DNA-depleted osteosarcoma cells
Biol. Cell
101
31-41
2009
Homo sapiens
Mayer, K.; Iolyeva, M.E.; Meyer-Grahle, U.; Brix, K.
Intestine-specific expression of green fluorescent protein-tagged cathepsin B: proof-of-principle experiments
Biol. Chem.
389
1085-1096
2008
Rattus norvegicus
Caglic, D.; Kosec, G.; Bojic, L.; Reinheckel, T.; Turk, V.; Turk, B.
Murine and human cathepsin B exhibit similar properties: possible implications for drug discovery
Biol. Chem.
390
175-179
2009
Homo sapiens (P07858), Homo sapiens, Mus musculus (P10605), Mus musculus
Vreemann, A.; Qu, H.; Mayer, K.; Andersen, L.B.; Stefana, M.I.; Wehner, S.; Lysson, M.; Farcas, A.M.; Peters, C.; Reinheckel, T.; Kalff, J.; Brix, K.
Cathepsin B release from rodent intestine mucosa due to mechanical injury results in extracellular matrix damage in early post-traumatic phases
Biol. Chem.
390
481-492
2009
Mus musculus
Kim, S.H.; Jhon, D.J.; Song, J.H.; No, J.S.; Kang, N.S.
Effect of novel N-cyano-tetrahydro-pyridazine compounds, a class of cathepsin K inhibitors, on the bone resorptive activity of mature osteoclasts
Bioorg. Med. Chem. Lett.
18
3988-3991
2008
Homo sapiens
Li, Y.; Qian, Z.J.; Kim, S.K.
Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeker
Bioorg. Med. Chem. Lett.
18
6130-6134
2008
Rattus norvegicus
Herszenyi, L.; Farinati, F.; Cardin, R.; Istvan, G.; Molnar, L.D.; Hritz, I.; De Paoli, M.; Plebani, M.; Tulassay, Z.
Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer
BMC Cancer
8
194
2008
Homo sapiens
Abu Ajaj, K.; Graeser, R.; Fichtner, I.; Kratz, F.
In vitro and in vivo study of an albumin-binding prodrug of doxorubicin that is cleaved by cathepsin B
Cancer Chemother. Pharmacol.
64
413-418
2009
Homo sapiens
Hwang, J.H.; Lee, S.H.; Lee, K.H.; Lee, K.Y.; Kim, H.; Ryu, J.K.; Yoon, Y.B.; Kim, Y.T.
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
Cancer Lett.
273
266-272
2009
Homo sapiens (P07858), Homo sapiens
Tu, C.; Ortega-Cava, C.F.; Chen, G.; Fernandes, N.D.; Cavallo-Medved, D.; Sloane, B.F.; Band, V.; Band, H.
Lysosomal cathepsin B participates in the podosome-mediated extracellular matrix degradation and invasion via secreted lysosomes in v-Src fibroblasts
Cancer Res.
68
9147-9156
2008
Mus musculus
Herszenyi, L.; Istvan, G.; Cardin, R.; De Paoli, M.; Plebani, M.; Tulassay, Z.; Farinati, F.
Serum cathepsin B and plasma urokinase-type plasminogen activator levels in gastrointestinal tract cancers
Eur. J. Cancer Prev.
17
438-445
2008
Homo sapiens
Cavallo-Medved, D.; Rudy, D.; Blum, G.; Bogyo, M.; Caglic, D.; Sloane, B.F.
Live-cell imaging demonstrates extracellular matrix degradation in association with active cathepsin B in caveolae of endothelial cells during tube formation
Exp. Cell Res.
315
1234-1246
2009
Homo sapiens
Tsai, H.T.; Wang, P.H.; Tee, Y.T.; Lin, L.Y.; Hsieh, Y.S.; Yang, S.F.
Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease
Fertil. Steril.
91
549-555
2009
Homo sapiens
Zhang, F.T.; Zhang, Y.B.; Chen, Y.D.; Zhu, R.; Dong, C.W.; Li, Y.Y.; Zhang, Q.Y.; Gui, J.F.
Expressional induction of Paralichthys olivaceus cathepsin B gene in response to virus, poly I:C and lipopolysaccharide
Fish Shellfish Immunol.
25
542-549
2008
Paralichthys olivaceus (Q68J69), Paralichthys olivaceus
Czyzewska, J.; Guzinska-Ustymowicz, K.; Kemona, A.; Bandurski, R.
The expression of matrix metalloproteinase 9 and cathepsin B in gastric carcinoma is associated with lymph node metastasis, but not with postoperative survival
Folia Histochem. Cytobiol.
46
57-64
2008
Homo sapiens
Vaeaenaenen, A.J.; Salmenperae, P.; Hukkanen, M.; Miranda, K.M.; Harjula, A.; Rauhala, P.; Kankuri, E.
Persistent susceptibility of cathepsin B to irreversible inhibition by nitroxyl (HNO) in the presence of endogenous nitric oxide
Free Radic. Biol. Med.
45
749-755
2008
Mus musculus
Devetzi, M.; Scorilas, A.; Tsiambas, E.; Sameni, M.; Fotiou, S.; Sloane, B.F.; Talieri, M.
Cathepsin B protein levels in endometrial cancer: Potential value as a tumour biomarker
Gynecol. Oncol.
112
531-536
2009
Homo sapiens
Redzynia, I.; Ljunggren, A.; Abrahamson, M.; Mort, J.S.; Krupa, J.C.; Jaskolski, M.; Bujacz, G.
Displacement of the occluding loop by the parasite protein, chagasin, results in efficient inhibition of human cathepsin B
J. Biol. Chem.
283
22815-22825
2008
Homo sapiens
Hook, V.Y.; Kindy, M.; Hook, G.
Inhibitors of cathepsin B improve memory and reduce beta-amyloid in transgenic Alzheimer disease mice expressing the wild-type, but not the Swedish mutant, beta-secretase site of the amyloid precursor protein
J. Biol. Chem.
283
7745-7753
2008
Mus musculus
Yamaguchi, T.; Naruishi, K.; Arai, H.; Nishimura, F.; Takashiba, S.
IL-6/sIL-6R enhances cathepsin B and L production via caveolin-1-mediated JNK-AP-1 pathway in human gingival fibroblasts
J. Cell. Physiol.
217
423-432
2008
Homo sapiens
Zhou, Z.; Wang, Y.; Bryant, S.H.
Computational analysis of the cathepsin B inhibitors activities through LR-MMPBSA binding affinity calculation based on docked complex
J. Comput. Chem.
30
2165-2175
2009
Bos taurus
Elkaim, R.; Werner, S.; Kocgozlu, L.; Tenenbaum, H.
P. gingivalis regulates the expression of cathepsin B and cystatin C
J. Dent. Res.
87
932-936
2008
Homo sapiens
Ha, S.D.; Martins, A.; Khazaie, K.; Han, J.; Chan, B.M.; Kim, S.O.
Cathepsin B is involved in the trafficking of TNF-alpha-containing vesicles to the plasma membrane in macrophages
J. Immunol.
181
690-697
2008
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Fricker, S.P.; Mosi, R.M.; Cameron, B.R.; Baird, I.; Zhu, Y.; Anastassov, V.; Cox, J.; Doyle, P.S.; Hansell, E.; Lau, G.; Langille, J.; Olsen, M.; Qin, L.; Skerlj, R.; Wong, R.S.; Santucci, Z.; McKerrow, J.H.
Metal compounds for the treatment of parasitic diseases
J. Inorg. Biochem.
102
1839-1845
2008
Homo sapiens
Casini, A.; Gabbiani, C.; Sorrentino, F.; Rigobello, M.P.; Bindoli, A.; Geldbach, T.J.; Marrone, A.; Re, N.; Hartinger, C.G.; Dyson, P.J.; Messori, L.
Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds
J. Med. Chem.
51
6773-6781
2008
Bos taurus
Hoang, l.e..T.V.; Kim, M.M.; Kim, S.K.
Effect of culture conditions on cathepsin B inhibitor production by a marine bacterium, Pseudomonas sp. strain PB01
J. Microbiol. Biotechnol.
18
1115-1120
2008
Bos taurus
Myers, J.; Ittiprasert, W.; Raghavan, N.; Miller, A.; Knight, M.
Differences in cysteine protease activity in Schistosoma mansoni-resistant and -susceptible Biomphalaria glabrata and characterization of the hepatopancreas cathepsin B full-length cDNA
J. Parasitol.
94
659-668
2008
Biomphalaria glabrata (A7LM75), Biomphalaria glabrata
Ranjit, N.; Zhan, B.; Stenzel, D.J.; Mulvenna, J.; Fujiwara, R.; Hotez, P.J.; Loukas, A.
A family of cathepsin B cysteine proteases expressed in the gut of the human hookworm, Necator americanus
Mol. Biochem. Parasitol.
160
90-99
2008
Necator americanus
Giusti, I.; D'Ascenzo, S.; Millimaggi, D.; Taraboletti, G.; Carta, G.; Franceschini, N.; Pavan, A.; Dolo, V.
Cathepsin B mediates the pH-dependent proinvasive activity of tumor-shed microvesicles
Neoplasia
10
481-488
2008
Homo sapiens
Sun, B.; Zhou, Y.; Halabisky, B.; Lo, I.; Cho, S.H.; Mueller-Steiner, S.; Devidze, N.; Wang, X.; Grubb, A.; Gan, L.
Cystatin C-cathepsin B axis regulates amyloid beta levels and associated neuronal deficits in an animal model of Alzheimers disease
Neuron
60
247-257
2008
Mus musculus
Sakamoto, M.; Miyamoto, K.; Wu, Z.; Nakanishi, H.
Possible involvement of cathepsin B released by microglia in methylmercury-induced cerebellar pathological changes in the adult rat
Neurosci. Lett.
442
292-296
2008
Rattus norvegicus
Vasiljeva, O.; Korovin, M.; Gajda, M.; Brodoefel, H.; Bojic, L.; Krueger, A.; Schurigt, U.; Sevenich, L.; Turk, B.; Peters, C.; Reinheckel, T.
Reduced tumour cell proliferation and delayed development of high-grade mammary carcinomas in cathepsin B-deficient mice
Oncogene
27
4191-4199
2008
Mus musculus
Abdulla, M.H.; OBrien, T.; Mackey, Z.B.; Sajid, M.; Grab, D.J.; McKerrow, J.H.
RNA interference of Trypanosoma brucei cathepsin B and L affects disease progression in a mouse model
PLoS Negl. Trop. Dis.
2
e298
2008
Trypanosoma brucei, Trypanosoma brucei 90-13
Schenker, P.; Alfarano, P.; Kolb, P.; Caflisch, A.; Baici, A.
A double-headed cathepsin B inhibitor devoid of warhead
Protein Sci.
17
2145-2155
2008
Homo sapiens
Aoki, T.; Kataoka, H.; Ishibashi, R.; Nozaki, K.; Hashimoto, N.
Cathepsin B, K, and S are expressed in cerebral aneurysms and promote the progression of cerebral aneurysms
Stroke
39
2603-2610
2008
Homo sapiens, Rattus norvegicus
Geraghty, P.; Rogan, M.P.; Greene, C.M.; Brantly, M.L.; ONeill, S.J.; Taggart, C.C.; McElvaney, N.G.
Alpha-1-antitrypsin aerosolised augmentation abrogates neutrophil elastase-induced expression of cathepsin B and matrix metalloprotease 2 in vivo and in vitro
Thorax
63
621-626
2008
Homo sapiens
Wang, C.; Jiang, Z.; Yao, J.; Wu, X.; Sun, L.; Liu, C.; Duan, W.; Yan, M.; Sun, L.; Liu, J.; Zhang, L.
Participation of cathepsin B in emodin-induced apoptosis in HK-2 cells
Toxicol. Lett.
181
196-204
2008
Homo sapiens
Yan, B.Z.; Wang, W.; Chen, L.Y.; Bi, M.R.; Lu, Y.J.; Li, B.X.; Yang, B.S.
Role of cathepsin B-mediated apoptosis in fulminant hepatic failure in mice
World J. Gastroenterol.
15
1231-1236
2009
Mus musculus
Colin, C.; Voutsinos-Porche, B.; Nanni, I.; Fina, F.; Metellus, P.; Intagliata, D.; Baeza, N.; Bouvier, C.; Delfino, C.; Loundou, A.; Chinot, O.; Lah, T.; Kos, J.; Martin, P.M.; Ouafik, L.; Figarella-Branger, D.
High expression of cathepsin B and plasminogen activator inhibitor type-1 are strong predictors of survival in glioblastomas
Acta Neuropathol.
118
745-754
2009
Homo sapiens
Li, J.H.; DAlessio, A.; Pober, J.S.
Lipopolysaccharide can trigger a cathepsin B-dependent programmed death response in human endothelial cells
Am. J. Pathol.
175
1124-1135
2009
Homo sapiens
Momeny, M.; Malehmir, M.; Zakidizaji, M.; Ghasemi, R.; Ghadimi, H.; Shokrgozar, M.A.; Emami, A.H.; Nafissi, S.; Ghavamzadeh, A.; Ghaffari, S.H.
Silibinin inhibits invasive properties of human glioblastoma U87MG cells through suppression of cathepsin B and nuclear factor kappa B-mediated induction of matrix metalloproteinase 9
Anticancer Drugs
21
252-260
2010
Homo sapiens
Hook, V.Y.; Kindy, M.; Reinheckel, T.; Peters, C.; Hook, G.
Genetic cathepsin B deficiency reduces beta-amyloid in transgenic mice expressing human wild-type amyloid precursor protein
Biochem. Biophys. Res. Commun.
386
284-288
2009
Mus musculus, Mus musculus C57BL/6
Morishige, T.; Yoshioka, Y.; Tanabe, A.; Yao, X.; Tsunoda, S.; Tsutsumi, Y.; Mukai, Y.; Okada, N.; Nakagawa, S.
Titanium dioxide induces different levels of IL-1beta production dependent on its particle characteristics through caspase-1 activation mediated by reactive oxygen species and cathepsin B
Biochem. Biophys. Res. Commun.
392
160-165
2010
Homo sapiens
Hwang, S.Y.; Yoo, B.C.; Jung, J.W.; Oh, E.S.; Hwang, J.S.; Shin, J.A.; Kim, S.Y.; Cha, S.H.; Han, I.O.
Induction of glioma apoptosis by microglia-secreted molecules: The role of nitric oxide and cathepsin B
Biochim. Biophys. Acta
1793
1656-1668
2009
Homo sapiens, Rattus norvegicus
Cunha, R.L.; Gouvea, I.E.; Feitosa, G.P.; Alves, M.F.; Broemme, D.; Comasseto, J.V.; Tersariol, I.L.; Juliano, L.
Irreversible inhibition of human cathepsins B, L, S and K by hypervalent tellurium compounds
Biol. Chem.
390
1205-1212
2009
Homo sapiens
Pucer, A.; Castino, R.; Mirkovi?, B.; Falnoga, I.; Slejkovec, Z.; Isidoro, C.; Lah, T.T.
Differential role of cathepsins B and L in autophagy-associated cell death induced by arsenic trioxide in U87 human glioblastoma cells
Biol. Chem.
391
519-531
2010
Homo sapiens
Song, G.; Bailey, D.W.; Dunlap, K.A.; Burghardt, R.C.; Spencer, T.E.; Bazer, F.W.; Johnson, G.A.
Cathepsin B, cathepsin L, and cystatin C in the porcine uterus and placenta: potential roles in endometrial/placental remodeling and in fluid-phase transport of proteins secreted by uterine epithelia across placental areolae
Biol. Reprod.
82
854-864
2010
Homo sapiens
Li, J.; Petrassi, H.; Tumanut, C.; Masick, B.; Trussell, C.; Harris, J.
Substrate optimization for monitoring cathepsin C activity in live cells
Bioorg. Med. Chem.
17
1064-1070
2009
Homo sapiens
Kenig, S.; Alonso, M.B.; Mueller, M.M.; Lah, T.T.
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9
Cancer Lett.
289
53-61
2010
Homo sapiens
Colella, R.; Lu, G.; Glazewski, L.; Korant, B.; Matlapudi, A.; England, M.R.; Craft, C.; Frantz, C.N.; Mason, R.W.
Induction of cell death in neuroblastoma by inhibition of cathepsins B and L
Cancer Lett.
294
195-203
2010
Homo sapiens
Oberle, C.; Huai, J.; Reinheckel, T.; Tacke, M.; Rassner, M.; Ekert, P.G.; Buellesbach, J.; Borner, C.
Lysosomal membrane permeabilization and cathepsin release is a Bax/Bak-dependent, amplifying event of apoptosis in fibroblasts and monocytes
Cell Death Differ.
17
1167-1178
2010
Mus musculus
Bhoopathi, P.; Chetty, C.; Gujrati, M.; Dinh, D.H.; Rao, J.S.; Lakka, S.
Cathepsin B facilitates autophagy-mediated apoptosis in SPARC overexpressed primitive neuroectodermal tumor cells
Cell Death Differ.
17
1529-1539
2010
Homo sapiens
Zhang, C.; Sun, J.B.; Liu, D.C.; Cui, Y.Q.; Liu, S.; Sun, H.C.
Preliminary research on the pathological role of cathepsin-B in subcutaneous heteroplastic pancreatic carcinoma in nude mice
Chin. Med. Sci.
122
2489-2496
2009
Mus musculus
Eykelbosh, A.J.; Van Der Kraak, G.
A role for the lysosomal protease cathepsin B in zebrafish follicular apoptosis
Comp. Biochem. Physiol. A
156
218-223
2010
Danio rerio (Q6PH75), Danio rerio
Lee, K.S.; Kim, B.Y.; Choo, Y.M.; Yoon, H.J.; Kang, P.D.; Woo, S.D.; Sohn, H.D.; Roh, J.Y.; Gui, Z.Z.; Je, Y.H.; Jin, B.R.
Expression profile of cathepsin B in the fat body of Bombyx mori during metamorphosis
Comp. Biochem. Physiol. B
154
188-194
2009
Bombyx mori
Chi, Y.H.; Koo, Y.D.; Dai, S.Y.; Ahn, J.E.; Yun, D.J.; Lee, S.Y.; Zhu-Salzman, K.
N-glycosylation at non-canonical Asn-X-Cys sequence of an insect recombinant cathepsin B-like counter-defense protein
Comp. Biochem. Physiol. B
156
40-47
2010
Callosobruchus maculatus
Tomoo, K.
Development of cathepsin inhibitors and structure-based design of cathepsin B-specific inhibitor
Curr. Top. Med. Chem.
10
696-707
2010
Homo sapiens
Huryn, D.M.; Smith, A.B.
The identification, characterization and optimization of small molecule probes of cysteine proteases: experiences of the Penn center for molecular discovery with cathepsin B and cathepsin L
Curr. Top. Med. Chem.
9
1206-1216
2009
Homo sapiens
Spencer, J.; Casini, A.; Zava, O.; Rathnam, R.P.; Velhanda, S.K.; Pfeffer, M.; Callear, S.K.; Hursthouse, M.B.; Dyson, P.J.
Excellent correlation between cathepsin B inhibition and cytotoxicity for a series of palladacycles
Dalton Trans.
2009
10731-10735
2009
Bos taurus, Homo sapiens
Spencer, J.; Rathnam, R.P.; Motukuri, M.; Kotha, A.K.; Richardson, S.C.; Hazrati, A.; Hartley, J.A.; Male, L.; Hursthouse, M.B.
Synthesis of a 1,4-benzodiazepine containing palladacycle with in vitro anticancer and cathepsin B activity
Dalton Trans.
2009
4299-4303
2009
Mus musculus
Casini, A.; Edafe, F.; Erlandsson, M.; Gonsalvi, L.; Ciancetta, A.; Re, N.; Ienco, A.; Messori, L.; Peruzzini, M.; Dyson, P.J.
Rationalization of the inhibition activity of structurally related organometallic compounds against the drug target cathepsin B by DFT
Dalton Trans.
39
5556-5563
2010
Homo sapiens
Kolwijck, E.; Kos, J.; Obermajer, N.; Span, P.N.; Thomas, C.M.; Massuger, L.F.; Sweep, F.C.
The balance between extracellular cathepsins and cystatin C is of importance for ovarian cancer
Eur. J. Clin. Invest.
40
591-599
2010
Homo sapiens
Mirkovic, B.; Premzl, A.; Hodnik, V.; Doljak, B.; Jevnikar, Z.; Anderluh, G.; Kos, J.
Regulation of cathepsin B activity by 2A2 monoclonal antibody
FEBS J.
276
4739-4751
2009
Homo sapiens
Pungercar, J.R.; Caglic, D.; Sajid, M.; Dolinar, M.; Vasiljeva, O.; Pozgan, U.; Turk, D.; Bogyo, M.; Turk, V.; Turk, B.
Autocatalytic processing of procathepsin B is triggered by proenzyme activity
FEBS J.
276
660-668
2009
Homo sapiens
Terada, K.; Yamada, J.; Hayashi, Y.; Wu, Z.; Uchiyama, Y.; Peters, C.; Nakanishi, H.
Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia
Glia
58
114-124
2010
Mus musculus, Mus musculus C57/Bl
Dong, Y.; Lin, J.; Lu, X.; Zheng, Z.; Ren, X.; Zhang, H.; He, J.; Yang, J.
Cathepsin B inhibitory tetraene lactones from the fungus Talaromyces wortmannii
Helv. Chim. Acta
92
567-574
2009
Mus musculus
-
Moles, A.; Tarrats, N.; Fernandez-Checa, J.C.; Mari, M.
Cathepsins B and D drive hepatic stellate cell proliferation and promote their fibrogenic potential
Hepatology
49
1297-1307
2009
Homo sapiens, Mus musculus, Mus musculus C57BL/6
Reich, M.; Wieczerzak, E.; Jankowska, E.; Palesch, D.; Boehm, B.O.; Burster, T.
Specific cathepsin B inhibitor is cell-permeable and activates presentation of TTC in primary human dendritic cells
Immunol. Lett.
123
155-159
2009
Homo sapiens
Beckham, S.A.; Piedrafita, D.; Phillips, C.I.; Samarawickrema, N.; Law, R.H.; Smooker, P.M.; Quinsey, N.S.; Irving, J.A.; Greenwood, D.; Verhelst, S.H.; Bogyo, M.; Turk, B.; Coetzer, T.H.; Wijeyewickrema, L.C.; Spithill, T.W.; Pike, R.N.
A major cathepsin B protease from the liver fluke Fasciola hepatica has atypical active site features and a potential role in the digestive tract of newly excysted juvenile parasites
Int. J. Biochem. Cell Biol.
41
1601-1612
2009
Fasciola hepatica, Homo sapiens
Ha, S.D.; Ham, B.; Mogridge, J.; Saftig, P.; Lin, S.; Kim, S.O.
Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm
J. Biol. Chem.
285
2120-2129
2010
Mus musculus, Mus musculus C57BL/6
Ahn, J.E.; Guarino, L.A.; Zhu-Salzman, K.
Coordination of hepatocyte nuclear factor 4 and seven-up controls insect counter-defense cathepsin B expression
J. Biol. Chem.
285
6573-6584
2010
Callosobruchus maculatus
Kolwijck, E.; Massuger, L.F.; Thomas, C.M.; Span, P.N.; Krasovec, M.; Kos, J.; Sweep, F.C.
Cathepsins B, L and cystatin C in cyst fluid of ovarian tumors
J. Cancer Res. Clin. Oncol.
136
771-778
2010
Homo sapiens
Duncan, J.A.; Gao, X.; Huang, M.T.; OConnor, B.P.; Thomas, C.E.; Willingham, S.B.; Bergstralh, D.T.; Jarvis, G.A.; Sparling, P.F.; Ting, J.P.
Neisseria gonorrhoeae activates the proteinase cathepsin B to mediate the signaling activities of the NLRP3 and ASC-containing inflammasome
J. Immunol.
182
6460-6469
2009
Homo sapiens, Mus musculus
Lalanne, A.I.; Moraga, I.; Hao, Y.; Pereira, J.P.; Alves, N.L.; Huntington, N.D.; Freitas, A.A.; Cumano, A.; Vieira, P.
CpG inhibits pro-B cell expansion through a cathepsin B-dependent mechanism
J. Immunol.
184
5678-5685
2010
Mus musculus
Mura, P.; Camalli, M.; Casini, A.; Gabbiani, C.; Messori, L.
Trans-cis-cis-[RuCl2(DMSO)2(2-amino-5-methyl-thiazole)2], (PMRu52), a novel ruthenium(II) compound acting as a strong inhibitor of cathepsin B
J. Inorg. Biochem.
104
111-117
2010
Bos taurus
Zhou, Z.; Wang, Y.; Bryant, S.H.
QSAR models for predicting cathepsin B inhibition by small molecules - continuous and binary QSAR models to classify cathepsin B inhibition activities of small molecules
J. Mol. Graph. Model.
28
714-727
2010
Homo sapiens
Johnson, E.M.; Doyle, J.D.; Wetzel, J.D.; McClung, R.P.; Katunuma, N.; Chappell, J.D.; Washington, M.K.; Dermody, T.S.
Genetic and pharmacologic alteration of cathepsin expression influences reovirus pathogenesis
J. Virol.
83
9630-9640
2009
Mus musculus, Mus musculus C57/BL6J
Puissant, A.; Colosetti, P.; Robert, G.; Cassuto, J.P.; Raynaud, S.; Auberger, P.
Cathepsin B release after imatinib-mediated lysosomal membrane permeabilization triggers BCR-ABL cleavage and elimination of chronic myelogenous leukemia cells
Leukemia
24
115-124
2010
Homo sapiens
Joy, B.; Sivadasan, R.; Abraham T, E.; John, M.; Sobhan, P.K.; Seervi, M.; Santhoshkumar, T.R.
Lysosomal destabilization and cathepsin B contributes for cytochrome c release and caspase activation in embelin-induced apoptosis
Mol. Carcinog.
49
324-336
2010
Homo sapiens
Oztay, F.; Gezginci-Oktayoglu, S.; Bayrak, B.B.; Yanardag, R.; Bolkent, S.
Cathepsin B inhibition improves lung injury associated to D-galactosamine/tumor necrosis factor-alpha-induced liver injury in mice
Mol. Cell. Biochem.
333
65-72
2010
Mus musculus
Lemaire, G.; Guittet, O.; Vesin, M.; Lepoivre, M.; Cottet, M.
Glutathione depletion reveals impairment of antigen processing and inhibition of cathepsin activity by nitric oxide in antigen-presenting cells
Mol. Immunol.
46
1100-1108
2009
Mus musculus, Mus musculus BALB/c
Balboula, A.Z.; Yamanaka, K.; Sakatani, M.; Hegab, A.O.; Zaabel, S.M.; Takahashi, M.
Cathepsin B activity is related to the quality of bovine cumulus oocyte complexes and its inhibition can improve their developmental competence
Mol. Reprod. Dev.
77
439-448
2010
Bos taurus
Gole, B.; Duran Alonso, M.B.; Dolenc, V.; Lah, T.
Post-translational regulation of cathepsin B, but not of other cysteine cathepsins, contributes to increased glioblastoma cell invasiveness in vitro
Pathol. Oncol. Res.
15
711-723
2009
Homo sapiens
Murata, R.M.; Yatsuda, R.; dos Santos, M.H.; Kohn, L.K.; Martins, F.T.; Nagem, T.J.; Alencar, S.M.; de Carvalho, J.E.; Rosalen, P.L.
Antiproliferative effect of benzophenones and their influence on cathepsin activity
Phytother. Res.
24
379-383
2010
Homo sapiens
De Vries, E.; Bakker, N.; Krijgsveld, J.; Knox, D.P.; Heck, A.J.; Yatsuda, A.P.
An AC-5 cathepsin B-like protease purified from Haemonchus contortus excretory secretory products shows protective antigen potential for lambs
Vet. Res.
40
41
2009
Haemonchus contortus (O44396), Haemonchus contortus
Bien, S.; Rimmbach, C.; Neumann, H.; Niessen, J.; Reimer, E.; Ritter, C.A.; Rosskopf, D.; Cinatl, J.; Michaelis, M.; Schroeder, H.W.; Kroemer, H.K.
Doxorubicin-induced cell death requires cathepsin B in HeLa cells
Biochem. Pharmacol.
80
1466-1477
2010
Homo sapiens
Costa, M.G.; Batista, P.R.; Shida, C.S.; Robert, C.H.; Bisch, P.M.; Pascutti, P.G.
How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics
BMC Genomics
11 Suppl 5
S5
2010
Homo sapiens (P07858)
Valadares, N.F.; Dellamano, M.; Soares-Costa, A.; Henrique-Silva, F.; Garratt, R.C.
Molecular determinants of improved cathepsin B inhibition by new cystatins obtained by DNA shuffling
BMC Struct. Biol.
10
30
2010
Homo sapiens
Stephens, A.; Rojo, L.; Araujo-Bernal, S.; Garcia-Carreno, F.; Muhlia-Almazan, A.
Cathepsin B from the white shrimp Litopenaeus vannamei: cDNA sequence analysis, tissues-specific expression and biological activity
Comp. Biochem. Physiol. B
161
32-40
2012
Penaeus vannamei
Chen, L.; Sun, L.
Cathepsin B of Cynoglossus semilaevis: identification, expression, and activity analysis
Comp. Biochem. Physiol. B
161
54-59
2012
Cynoglossus semilaevis (G9FTP5), Cynoglossus semilaevis
Yang, Y.; Qin, W.; Wei, H.; Ying, J.; Zhen, J.
Characterization of cathepsin B proteinase (AcCP-2) in eggs and larvae stages of hookworm Ancylostoma caninum
Exp. Parasitol.
129
215-220
2011
Ancylostoma caninum
Asai, M.; Yagishita, S.; Iwata, N.; Saido, T.C.; Ishiura, S.; Maruyama, K.
An alternative metabolic pathway of amyloid precursor protein C-terminal fragments via cathepsin B in a human neuroglioma model
FASEB J.
25
3720-3730
2011
Homo sapiens
Sun, L.; Zhu, B.; Wu, H.; Yu, L.; Zhou, D.; Dong, X.; Yang, J.; Li, D.; Ye, W.; Murata, Y.
Purification and characterization of cathepsin B from the gut of the sea cucumber (Stichopus japonicas)
Food Sci. Biotechnol.
20
919-925
2011
Apostichopus japonicus
-
Wang, X.; Liu, B.; Tang, B.; Xiang, J.
Potential role of cathepsin B in the embryonic and larval development of clam Meretrix meretrix
J. Exp. Zool. B
316 B
306-312
2011
Meretrix meretrix
Yao, X.; Zhang, J.; Sun, J.; Liu, B.
Recombinant expression, characterization and expressional analysis of clam Meretrix meretrix cathepsin B, an enzyme involved in nutrient digestion
Mol. Biol. Rep.
38
1861-1868
2011
Meretrix meretrix (B6CPA2), Meretrix meretrix
Wisastra, R.; Ghizzoni, M.; Maarsingh, H.; Minnaard, A.J.; Haisma, H.J.; Dekker, F.J.
Isothiazolones; thiol-reactive inhibitors of cysteine protease cathepsin B and histone acetyltransferase PCAF
Org. Biomol. Chem.
9
1817-1822
2011
Homo sapiens
Malagon, D.; Daz-Lopez, M.; Bentez, R.; Adroher, F.
Cathepsin B- and L-like cysteine protease activities during the in vitro development of Hysterothylacium aduncum (Nematoda: Anisakidae), a worldwide fish parasite
Parasitol. Int.
59
89-92
2010
Hysterothylacium aduncum
Han, Y.P.; Li, Z.Y.; Li, B.C.; Sun, X.; Zhu, C.C.; Ling, X.T.; Zheng, H.Q.; Wu, Z.D.; Lv, Z.Y.
Molecular cloning and characterization of a cathepsin B from Angiostrongylus cantonensis
Parasitol. Res.
109
369-378
2011
Angiostrongylus cantonensis
Raghav, N.; Garg, S.
N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Chem.
57
43-50
2014
Capra hircus (H9B8T9)
Raghav, N.; Singh, M.
Acyl hydrazides and triazoles as novel inhibitors of mammalian cathepsin B and cathepsin H
Eur. J. Med. Chem.
77
231-242
2014
Capra hircus (H9B8T9)
Gogiel, T.; Galewska, Z.; Romanowicz, L.
Differential distribution of cathepsin B in human umbilical cord tissues
Acta Biochim. Pol.
59
679-684
2012
Homo sapiens (P07858), Homo sapiens
Kim, C.J.; Lee, D.I.; Zhang, D.; Lee, C.H.; Ahn, I.S.
New strategy for selective and sensitive assay of cathepsin B using a dityrosine-based material
Anal. Biochem.
435
166-173
2013
Homo sapiens (P07858)
Hsu, S.F.; Hsu, C.C.; Cheng, B.C.; Lin, C.H.
Cathepsin B is involved in the heat shock induced cardiomyocytes apoptosis as well as the anti-apoptosis effect of HSP-70
Apoptosis
19
1571-1580
2014
Rattus norvegicus (P00787)
Wyczalkowska-Tomasik, A.; Plczek, L.
Cathepsin B and L activity in the serum during the human aging process: cathepsin B and L in aging
Arch. Gerontol. Geriatr.
55
735-738
2012
Homo sapiens
Morchang, A.; Panaampon, J.; Suttitheptumrong, A.; Yasamut, U.; Noisakran, S.; Yenchitsomanus, P.T.; Limjindaporn, T.
Role of cathepsin B in dengue virus-mediated apoptosis
Biochem. Biophys. Res. Commun.
438
20-25
2013
Homo sapiens (P07858), Homo sapiens
Raghav, N.; Singh, M.
SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H
Bioorg. Med. Chem.
22
4233-4245
2014
Capra hircus (H9B8T9)
Niu, D.; Jin, K.; Wang, L.; Sun, F.; Li, J.
Identification of cathepsin B in the razor clam Sinonovacula constricta and its role in innate immune responses
Dev. Comp. Immunol.
41
94-99
2013
Sinonovacula constricta (R4MY40), Sinonovacula constricta
Li, M.; Li, Q.; Yang, Z.; Hu, G.; Li, T.; Chen, X.; Ao, J.
Identification of cathepsin B from large yellow croaker (Pseudosciaena crocea) and its role in the processing of MHC class II-associated invariant chain
Dev. Comp. Immunol.
45
313-320
2014
Larimichthys crocea (A0A0F8AU16), Larimichthys crocea
Chantree, P.; Phatsara, M.; Meemon, K.; Chaichanasak, P.; Changklungmoa, N.; Kueakhai, P.; Lorsuwannarat, N.; Sangpairoj, K.; Songkoomkrong, S.; Wanichanon, C.; Itagaki, T.; Sobhon, P.
Vaccine potential of recombinant cathepsin B against Fasciola gigantica
Exp. Parasitol.
135
102-109
2013
Fasciola gigantica (Q86MW7), Fasciola gigantica
Yu, C.; Wang, Y.; Zhang, J.; Fang, W.; Luo, D.
Immunolocalization and developmental expression patterns of two cathepsin B proteases (AC-cathB-1, -2) of Angiostrongylus cantonensis
Exp. Parasitol.
144
27-33
2014
Angiostrongylus cantonensis
Zhou, Z.J.; Qiu, R.; Zhang, J.
Molecular characterization of the cathepsin B of turbot (Scophthalmus maximus)
Fish Physiol. Biochem.
41
473-483
2015
Scophthalmus maximus (Q27HX3), Scophthalmus maximus
Alli, A.A.; Song, J.Z.; Al-Khalili, O.; Bao, H.F.; Ma, H.P.; Alli, A.A.; Eaton, D.C.
Cathepsin B is secreted apically from Xenopus 2F3 cells and cleaves the epithelial sodium channel (ENaC) to increase its activity
J. Biol. Chem.
287
30073-30083
2012
Xenopus laevis
Wang, C.; Sun, B.; Zhou, Y.; Grubb, A.; Gan, L.
Cathepsin B degrades amyloid-beta in mice expressing wild-type human amyloid precursor protein
J. Biol. Chem.
287
39834-39841
2012
Mus musculus
Li, S.; Du, L.; Zhang, L.; Hu, Y.; Xia, W.; Wu, J.; Zhu, J.; Chen, L.; Zhu, F.; Li, C.; Yang, S.
Cathepsin B contributes to autophagy-related 7 (Atg7)-induced nod-like receptor 3 (NLRP3)-dependent proinflammatory response and aggravates lipotoxicity in rat insulinoma cell line
J. Biol. Chem.
288
30094-30104
2013
Rattus norvegicus
Wong, W.P.; Altemus, J.B.; Hester, J.F.; Chan, E.R.; Cote, J.F.; Serre, D.; Sehayek, E.
Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine
J. Lipid Res.
54
816-822
2013
Mus musculus
Sosic, I.; Mirkovic, B.; Arenz, K.; Stefane, B.; Kos, J.; Gobec, S.
Development of new cathepsin B inhibitors: combining bioisosteric replacements and structure-based design to explore the structure-activity relationships of nitroxoline derivatives
J. Med. Chem.
56
521-533
2013
Homo sapiens
Edem, P.E.; Czorny, S.; Valliant, J.F.
Synthesis and evaluation of radioiodinated acyloxymethyl ketones as activity-based probes for cathepsin B
J. Med. Chem.
57
9564-9577
2014
Homo sapiens (P07858)
Bian, B.; Mongrain, S.; Cagnol, S.; Langlois, M.; Boulanger, J.; Bernatchez, G.; Carrier, J.; Boudreau, F.; Rivard, N.
Cathepsin B promotes colorectal tumorigenesis, cell invasion, and metastasis
Mol. Carcinog.
55
671-687
2015
Homo sapiens (P07858), Homo sapiens
Lee, J.; Kim, J.H.; Sohn, H.J.; Yang, H.J.; Na, B.K.; Chwae, Y.J.; Park, S.; Kim, K.; Shin, H.J.
Novel cathepsin B and cathepsin B-like cysteine protease of Naegleria fowleri excretory-secretory proteins and their biochemical properties
Parasitol. Res.
113
2765-2776
2014
Naegleria fowleri (X5D761), Naegleria fowleri (X5D911), Naegleria fowleri
Chen, W.; Wang, X.; Lv, X.; Tian, Y.; Xu, Y.; Mao, Q.; Shang, M.; Li, X.; Huang, Y.; Yu, X.
Characterization of the secreted cathepsin B cysteine proteases family of the carcinogenic liver fluke Clonorchis sinensis
Parasitol. Res.
113
3409-3418
2014
Clonorchis sinensis (A1YLF1), Clonorchis sinensis (A1YLF2), Clonorchis sinensis (A3R0V6), Clonorchis sinensis (B0L0Y4), Clonorchis sinensis
Balboula, A.Z.; Yamanaka, K.; Sakatani, M.; Kawahara, M.; Hegab, A.O.; Zaabel, S.M.; Takahashi, M.
Cathepsin B activity has a crucial role in the developmental competence of bovine cumulus-oocyte complexes exposed to heat shock during in vitro maturation
Reproduction
146
407-417
2013
Bos taurus (P07688), Bos taurus
Toomey, C.B.; Cauvi, D.M.; Hamel, J.C.; Ramirez, A.E.; Pollard, K.M.
Cathepsin B regulates the appearance and severity of mercury-induced inflammation and autoimmunity
Toxicol. Sci.
142
339-349
2014
Mus musculus (P07858), Mus musculus
Ni, J.; Wu, Z.; Stoka, V.; Meng, J.; Hayashi, Y.; Peters, C.; Qing, H.; Turk, V.; Nakanishi, H.
Increased expression and altered subcellular distribution of cathepsin B in microglia induce cognitive impairment through oxidative stress and inflammatory response in mice
Aging Cell
18
e12856
2019
Mus musculus (P10605)
Xiaofei, C.; Yanqing, L.; Dongkai, Z.; Dong, C.; Feng, Z.; Weilin, W.
Identification of cathepsin B as a novel target of hypoxia-inducible factor-1-alpha in HepG2 cells
Biochem. Biophys. Res. Commun.
503
1057-1062
2018
Mus musculus (P10605)
Siricoon, S.; Vichasri Grams, S.; Lertwongvisarn, K.; Abdullohfakeeyah, M.; Smooker, P.M.; Grams, R.
Fasciola gigantica cathepsin B5 is an acidic endo- and exopeptidase of the immature and mature parasite
Biochimie
119
6-15
2015
Fasciola gigantica (A0A0U4HGR1), Fasciola gigantica
Niemer, M.; Mehofer, U.; Verdianz, M.; Porodko, A.; Schaehs, P.; Kracher, D.; Lenarcic, B.; Novinec, M.; Mach, L.
Nicotiana benthamiana cathepsin B displays distinct enzymatic features which differ from its human relative and aleurain-like protease
Biochimie
122
119-125
2016
Nicotiana benthamiana (Q1HER6), Nicotiana benthamiana
Zhang, X.; Yang, X.; Wang, H.; Li, S.; Guo, K.; Jiang, D.; Xiao, J.; Liang, D.
Design, synthesis, and structure-activity relationship study of epoxysuccinyl-peptide derivatives as cathepsin B inhibitors
Biol. Pharm. Bull.
40
1240-1246
2017
Homo sapiens (P07858)
Schmitz, J.; Gilberg, E.; Loeser, R.; Bajorath, J.; Bartz, U.; Guetschow, M.
Cathepsin B Active site mapping with peptidic substrates and inhibitors
Bioorg. Med. Chem.
27
1-15
2019
Homo sapiens (P07858), Homo sapiens
Sosic, I.; Mitrovic, A.; Curic, H.; Knez, D.; Brodnik Zugelj, H.; Stefane, B.; Kos, J.; Gobec, S.
Cathepsin B inhibitors Further exploration of the nitroxoline core
Bioorg. Med. Chem. Lett.
28
1239-1247
2018
Homo sapiens (P07858), Homo sapiens
Mijanovic, O.; Brankovic, A.; Panin, A.N.; Savchuk, S.; Timashev, P.; Ulasov, I.; Lesniak, M.S.
Cathepsin B A sellsword of cancer progression
Cancer Lett.
449
207-214
2019
Homo sapiens (P07858)
Chen, N.; Ou, Z.; Zhang, W.; Zhu, X.; Li, P.; Gong, J.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells
Cell Prolif.
51
e12487
2018
Homo sapiens (P07858), Homo sapiens, Mus musculus (P10605)
Kryczka, J.; Papiewska-Pajak, I.; Kowalska, M.A.; Boncela, J.
Cathepsin B is upregulated and mediates ECM degradation in dolon adenocarcinoma HT29 cells overexpressing snail
Cells
8
203
2019
Homo sapiens (P07858)
Yi, P.; Hu, X.; Hu, B.; Wen, C.; Li, Z.
Identification and expression of cathepsin B from the freshwater mussel Cristaria plicata
Comp. Biochem. Physiol. B
225
21-28
2018
Cristaria plicata (F6MIV7), Cristaria plicata
Langdon, Y.G.; Fuentes, R.; Zhang, H.; Abrams, E.W.; Marlow, F.L.; Mullins, M.C.
Split top a maternal cathepsin B that regulates dorsoventral patterning and morphogenesis
Development
143
1016-1028
2016
Danio rerio
Kirschke, H.; Wikstrom, P.; Shaw, E.
Active center differences between cathepsins L and B the S, binding region
FEBS Lett.
228
128-130
1988
Rattus norvegicus (P00787)
-
Dai, L.S.; Sun, Y.; Sun, Y.X.; Zhu, B.J.; Liu, C.L.
Characterization and function of a cathepsin B in red crayfish (Procambarus clarkii) following lipopolysaccharide challenge
Fish Shellfish Immunol.
56
162-168
2016
Procambarus clarkii
Chen, H.; Lv, M.; Lv, Z.; Li, C.; Xu, W.; Zhang, W.; Zhao, X.; Duan, X.; Jin, C.
Molecular cloning and functional characterization of cathepsin B from the sea cucumber Apostichopus japonicus
Fish Shellfish Immunol.
60
447-457
2017
Apostichopus japonicus (A0A1S5RQP9), Apostichopus japonicus
Liang, F.R.; He, H.S.; Zhang, C.W.; Xu, X.M.; Zeng, Z.P.; Yuan, J.P.; Hong, Y.H.; Wang, J.H.
Molecular cloning and functional characterization of cathepsin B from Nile tilapia (Oreochromis niloticus)
Int. J. Biol. Macromol.
116
71-83
2018
Oreochromis niloticus (A0A2U8JGA6), Oreochromis niloticus
Li, Y.; Wang, K.; Xie, H.; Wang, D.W.; Xu, C.L.; Huang, X.; Wu, W.J.; Li, D.L.
Cathepsin B cysteine proteinase is essential for the development and pathogenesis of the plant parasitic nematode Radopholus similis
Int. J. Biol. Sci.
11
1073-1087
2015
Radopholus similis (G8Z9T0), Radopholus similis
Downs, C.A.; Dang, V.D.; Johnson, N.M.; Denslow, N.D.; Alli, A.A.
Hydrogen peroxide stimulates exosomal cathepsin B regulation of the receptor for advanced glycation end-products (RAGE)
J. Cell. Biochem.
119
599-606
2018
Rattus norvegicus (P00787)
Araujo, T.F.; Cordeiro, A.V.; Vasconcelos, D.A.A.; Vitzel, K.F.; Silva, V.R.R.
The role of cathepsin B in autophagy during obesity A systematic review
Life Sci.
209
274-281
2018
Homo sapiens (P07858)
Yoshida, A.; Ohta, M.; Kuwahara, K.; Cao, M.J.; Hara, K.; Osatomi, K.
Purification and characterization of cathepsin B from the muscle of horse mackerel Trachurus japonicus
Mar. Drugs
13
6550-6565
2015
Trachurus japonicus (A0A0P0YP15), Trachurus japonicus
Dhanavade, M.J.; Parulekar, R.S.; Kamble, S.A.; Sonawane, K.D.
Molecular modeling approach to explore the role of cathepsin B from Hordeum vulgare in the degradation of Abeta peptides
Mol. Biosyst.
12
162-168
2016
Hordeum vulgare (F2E819), Hordeum vulgare
Ramalho, S.D.; de Sousa, L.R.; Burger, M.C.; Lima, M.I.; da Silva, M.F.; Fernandes, J.B.; Vieira, P.C.
Evaluation of flavonols and derivatives as human cathepsin B inhibitor
Nat. Prod. Res.
29
2212-2214
2015
Homo sapiens (P07858), Homo sapiens
Peng, Y.; Zhang, M.; Zheng, L.; Liang, Q.; Li, H.; Chen, J.T.; Guo, H.; Yoshina, S.; Chen, Y.Z.; Zhao, X.; Wu, X.; Liu, B.; Mitani, S.; Yu, J.S.; Xue, D.
Cysteine protease cathepsin B mediates radiation-induced bystander effects
Nature
547
458-462
2017
Caenorhabditis elegans (P43508), Caenorhabditis elegans
Cai, Y.M.; Yu, J.; Ge, Y.; Mironov, A.; Gallois, P.
Two proteases with caspase-3-like activity, cathepsin B and proteasome, antagonistically control ER-stress-induced programmed cell death in Arabidopsis
New Phytol.
218
1143-1155
2018
Arabidopsis thaliana
Chen, W.; Ning, D.; Wang, X.; Chen, T.; Lv, X.; Sun, J.; Wu, D.; Huang, Y.; Xu, J.; Yu, X.
Identification and characterization of Clonorchis sinensis cathepsin B proteases in the pathogenesis of clonorchiasis
Parasit. Vectors
8
647
2015
Clonorchis sinensis, Clonorchis sinensis (A1YLF1), Clonorchis sinensis (A1YLF2), Clonorchis sinensis (B0L0Y4)
Demcsak, A.; Geisz, A.; Sahin-Toth, M.
Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B
Sci. Rep.
9
9188
2019
Mus musculus (P10605), Mus musculus
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