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Literature summary for 3.4.22.1 extracted from

  • Ha, S.D.; Ham, B.; Mogridge, J.; Saftig, P.; Lin, S.; Kim, S.O.
    Cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor into the cytoplasm (2010), J. Biol. Chem., 285, 2120-2129.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me cathepsin B inhibitor IV. Inhibition of cathepsin B blocks MEK1 cleavage induced by anthrax lethal toxin through delaying LeTx release into the cytoplasm. The cathepsin B inhibitor prevents cell death induced by anthrax lethal toxin in RAW 264.7 macrophages Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57BL/6 mice
-
Mus musculus C57BL/6
-
 C57BL/6 mice
-

Source Tissue

Source Tissue Comment Organism Textmining
macrophage bone marrow-derived Mus musculus
-

Synonyms

Synonyms Comment Organism
CTSB
-
 Mus musculus

General Information

General Information Comment Organism
malfunction cathepsin B-mediated autophagy flux facilitates the anthrax toxin receptor 2-mediated delivery of anthrax lethal factor, LeTx, into the cytoplasm, requiring lysosomal fusion with LeTx-containing endosomes. Anthrax lethal toxin is a virulence factor secreted by Bacillus anthracis and has direct cytotoxic effects on most cells once released into the cytoplasm. Inhibition of cathepsin B blocks MEK1 cleavage induced by anthrax lethal toxin through delaying LeTx release into the cytoplasm Mus musculus
physiological function CTSB is a lysosomal cysteine protease primarily involved in the degradation or processing of lysosomal proteins Mus musculus