Literature summary for 3.4.22.1 extracted from

Kenig, S.; Alonso, M.B.; Mueller, M.M.; Lah, T.T.
Glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9 (2010), Cancer Lett., 289, 53-61.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	no inhibition of cathepsin B by SDF-1 in vivo	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
lysosome	-	Homo sapiens	5764	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HMEC-1 cell	microvascular endothelial cells	Homo sapiens	-
U-87MG cell	glioblastoma cells	Homo sapiens	-

General Information

General Information	Comment	Organism
malfunction	glioblastoma and endothelial cells cross-talk, mediated by SDF-1, enhances tumour invasion and endothelial proliferation by increasing expression of cathepsins B, S, and MMP-9. Enhanced invasiveness correlates with increased expression of MMP-9 in both U87 and HMEC-1 cells, increased expression of cysteine cathepsins B and S and down-regulation of endogenous cell adhesion molecule NCAM in U-87 cells. U-87 tumour cells significantly enhance the proliferation of co-cultured endothelial cells by a mechanism involving cathepsin B, but not cathepsin S, overview. Regulation of invasion of U-87 cells involves cathepsin B, overview	Homo sapiens

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Release 2023.1 (January 2023)