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Literature summary for 3.4.22.1 extracted from

  • Raghav, N.; Singh, M.
    SAR studies of differently functionalized chalcones based hydrazones and their cyclized derivatives as inhibitors of mammalian cathepsin B and cathepsin H (2014), Bioorg. Med. Chem., 22, 4233-4245.
    View publication on PubMed
Search for more literature for 3.4.22.1

Inhibitors

Inhibitors Comment Organism Structure
1,3,5-triphenyl pyrazole
-
 Capra hircus
1,3,5-triphenyl-2-pyrazoline
-
 Capra hircus
3,5-diphenyl-2-pyrazoline
-
 Capra hircus
4-bromochalcone phenyl hydrazone
-
 Capra hircus
4-chlorochalcone phenyl hydrazone
-
 Capra hircus
4-methoxychalcone phenyl hydrazone
-
 Capra hircus
4-methylchalcone phenyl hydrazone
-
 Capra hircus
4-nitrochalcone phenyl hydrazone
-
 Capra hircus
5-(4-bromophenyl)-1,3-diphenyl pyrazole
-
 Capra hircus
5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline
-
 Capra hircus
5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
5-(4-chlorophenyl)-1,3-diphenyl pyrazole
-
 Capra hircus
5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline
-
 Capra hircus
5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
5-(4-methoxyphenyl)-1,3-diphenyl pyrazole
-
 Capra hircus
5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline
-
 Capra hircus
5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
5-(4-methylphenyl)-1,3-diphenyl pyrazole
-
 Capra hircus
5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline
-
 Capra hircus
5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
5-(4-nitrophenyl)-1,3-diphenyl pyrazole
-
 Capra hircus
5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline
-
 Capra hircus
5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
chalcone phenyl hydrazone
-
 Capra hircus
N-acetyl-3,5-diphenyl pyrazolines
-
 Capra hircus
N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus
N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline
-
 Capra hircus

Organism

Organism UniProt Comment Textmining
Capra hircus H9B8T9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Capra hircus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01038
-
 pH 6, 37°C Capra hircus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-Arg-2-naphthylamide + H2O
-
 Capra hircus N-benzoyl-L-Arg + 2-naphthylamine
-
 ?

Synonyms

Synonyms Comment Organism
cathepsin B
-
 Capra hircus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Capra hircus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
 assay at Capra hircus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000042
-
 4-nitrochalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.000053
-
 5-(4-bromophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.000131
-
 5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.001311
-
 5-(4-methoxyphenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.001311
-
 5-(4-nitrophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
0.001365
-
 5-(4-methylphenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.00288
-
 4-methoxychalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.00315
-
 4-methylchalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.00328
-
 4-chlorochalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.003883
-
 4-bromochalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.0047
-
 5-(4-methoxyphenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
0.007243
-
 5-(4-methylphenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
0.01
-
 5-(4-chlorophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.01141
-
 N-acetyl-5-(4-nitrophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.01274
-
 5-(4-nitrophenyl)-1,3-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.01274
-
 chalcone phenyl hydrazone pH 6, 37°C Capra hircus
0.01481
-
 5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.01767
-
 N-acetyl-3,5-diphenyl pyrazolines pH 6, 37°C Capra hircus
0.0178
-
 5-(4-chlorophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
0.038
-
 5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.04
-
 3,5-diphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.0526
-
 5-(4-bromophenyl)-1,3-diphenyl pyrazole pH 6, 37°C Capra hircus
0.06711
-
 N-acetyl-5-(4-bromophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.07407
-
 5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.08
-
 1,3,5-triphenyl pyrazole pH 6, 37°C Capra hircus
0.0909
-
 1,3,5-triphenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.1087
-
 N-acetyl-5-(4-chlorophenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.1143
-
 5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
0.149
-
 N-acetyl-5-(4-methoxyphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus
1.25
-
 N-acetyl-5-(4-methylphenyl)-3-phenyl-2-pyrazoline pH 6, 37°C Capra hircus