Literature summary for 3.4.22.1 extracted from

Hsu, S.F.; Hsu, C.C.; Cheng, B.C.; Lin, C.H.
Cathepsin B is involved in the heat shock induced cardiomyocytes apoptosis as well as the anti-apoptosis effect of HSP-70 (2014), Apoptosis, 19, 1571-1580.

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Inhibitors

Inhibitors	Comment	Organism	Structure
E-64c	inhibition of Cathepsin B alone not only reduces hyperthermic injury-induced apoptosis significantly but enhances the beneficial effects of preinduction of HSP-70 in reducing hyperthermic injury-induced apoptosis in H9C2 cells significantly	Rattus norvegicus

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	P00787	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
H9c2 cell	-	Rattus norvegicus	-

Synonyms

Synonyms	Comment	Organism
cathepsin B	-	Rattus norvegicus

General Information

General Information	Comment	Organism
physiological function	cathepsin B is involved in hyperthermic injury-induced cardiomyocyte apoptosis in H9C2 cells and HSP-70 protects these cells from hyperthermic injury-induced cardiomyocyte apoptosis through cathepsin B pathways	Rattus norvegicus

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Release 2023.1 (January 2023)