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Literature summary for 3.4.22.1 extracted from
- Hydroxynonenal inactivates cathepsin B by forming Michael adducts with active site residues (2002), Protein Sci., 11, 831-840.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | accumulation of undegraded macromolecules in lysosomes after oxidative damage are caused in part by direct protease inactivation by adduct formation with lipid peroxidation products | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-hydroxy-2-nonenal | 0.015 mM, 76% loss of activity, formation of Michael adducts with C29 of A chain and H150 of B chain | Bos taurus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
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Release 2023.1 (January 2023)
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