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BRENDA support

Literature summary for 3.4.22.1 extracted from

  • Costa, M.G.; Batista, P.R.; Shida, C.S.; Robert, C.H.; Bisch, P.M.; Pascutti, P.G.
    How does heparin prevent the pH inactivation of cathepsin B? Allosteric mechanism elucidated by docking and molecular dynamics (2010), BMC Genomics, 11 Suppl 5, S5.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens P07858
-
-

Synonyms

Synonyms Comment Organism
CatB
-
Homo sapiens

pH Stability

pH Stability pH Stability Maximum Comment Organism
5.5
-
cathepsin B shows high stability in acidic pH 5.5 Homo sapiens
8
-
cathepsin B loses stability and activity at pH 8.0, heparin binding prevents cathepsin B destabilization at pH 8.0 Homo sapiens