Application | Comment | Organism |
---|---|---|
medicine | pharmacologic modulation of cathepsin activity diminishes reovirus disease severity | Mus musculus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
lysosome | - |
Mus musculus | 5764 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
C57BL/6J mice | - |
Mus musculus C57/BL6J | - |
C57BL/6J mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Mus musculus | - |
heart | - |
Mus musculus | - |
intestine | - |
Mus musculus | - |
L-929 cell | - |
Mus musculus | - |
liver | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
CTSB | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | the cathepsin family of endosomal proteases is required for proteolytic processing of several viruses during entry into host cells, cathepsins contribute to reovirus tropism, spread, and disease outcome. Mammalian reoviruses utilize cathepsins B, L, and S for disassembly of the virus outer capsid and activation of the membrane penetration machinery. The survival rate of Ctsb-/- mice infected with reovirus is enhanced in comparison to that of wild-type mice, viremia in wild-type and cathepsin-deficient mice following peroral inoculation, overview | Mus musculus |