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Literature summary for 3.4.22.1 extracted from

  • Li, Y.; Qian, Z.J.; Kim, S.K.
    Cathepsin B inhibitory activities of three new phthalate derivatives isolated from seahorse, Hippocampus Kuda Bleeker (2008), Bioorg. Med. Chem. Lett., 18, 6130-6134.
    View publication on PubMed
Search for more literature for 3.4.22.1

Application

Application Comment Organism
medicine cathepsin B inhibitors are expected to be useful for the treatment of inflammatory joint disease, invasion of cancer, and other diseases related to cathepsin B disorder Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
2-ethyldecyl 2-ethylundecyl phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
bis(2-ethyldodecyl) phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
bis(2-ethylheptyl) phthalate isolated from seahorse, Hippocampus Kuda Bleeker, NMR structure determination and analysis, overview Rattus norvegicus
cystatin
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus effective inhibition of cathepsin B can decrease the severity of joint inflammation and to reduce the destruction of particular tissues in the rat model of antigen adjuvant-induced arthritis ?
-
 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information effective inhibition of cathepsin B can decrease the severity of joint inflammation and to reduce the destruction of particular tissues in the rat model of antigen adjuvant-induced arthritis Rattus norvegicus ?
-
 ?
additional information cathepsin B is a lysosomal cysteine protease, a unique cysteine member showing dual roles as both endopeptidase and exopeptidase activities due to the presence of the occluding loop in structure Rattus norvegicus ?
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.13
-
-
 Rattus norvegicus 2,12-diethyl-11-methylhexadecyl 2-ethyl-11-methylhexadecyl phthalate
0.18
-
-
 Rattus norvegicus bis(2-ethyldodecyl) phthalate
0.21
-
-
 Rattus norvegicus 2-ethyldecyl 2-ethylundecyl phthalate
0.29
-
-
 Rattus norvegicus bis(2-ethylheptyl) phthalate