Literature summary for 3.4.22.1 extracted from

Chen, N.; Ou, Z.; Zhang, W.; Zhu, X.; Li, P.; Gong, J.
Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells (2018), Cell Prolif., 51, e12487 .

Search for more literature for 3.4.22.1

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytosol	-	Homo sapiens	5829	-
cytosol	-	Mus musculus	5829	-

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07858	-	-
Mus musculus	P10605	TLR4-/- mice	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
peripheral blood mononuclear cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	upregulation of cathepsin B activity and caspase-4 activation in peripheral blood mononuclear cells of patients with Systemic Inflammatory Response Syndrome or sepsis	up

General Information

General Information	Comment	Organism
physiological function	the enzyme has critical role as activators of proinflammatory caspases-11 and the regulatory effect in LPS-induced caspases-11-dependent necrosis	Mus musculus

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Release 2023.1 (January 2023)