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Literature summary for 3.4.22.1 extracted from

  • Raghav, N.; Garg, S.
    N-formylpyrazolines and N-benzoylpyrazolines as novel inhibitors of mammalian cathepsin B and cathepsin H (2014), Bioorg. Chem., 57, 43-50.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
N-benzoyl-3,5-diphenylpyrazoline
-
Capra hircus
N-benzoyl-5-(2-chloro phenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(2-methoxyphenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(2-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(3-chloro phenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(3-methoxy phenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(3-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(4-chloro phenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(4-methoxy phenyl)-3-phenylpyrazoline
-
Capra hircus
N-benzoyl-5-(4-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-3,5-diphenylpyrazoline
-
Capra hircus
N-formyl-5-(2-chlorophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(2-methoxyphenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(2-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(3-chlorophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(3-methoxyphenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(3-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(4-chlorophenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(4-methoxyphenyl)-3-phenylpyrazoline
-
Capra hircus
N-formyl-5-(4-nitrophenyl)-3-phenylpyrazoline
-
Capra hircus

Organism

Organism UniProt Comment Textmining
Capra hircus H9B8T9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
Capra hircus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.01115
-
pH 6, 37°C Capra hircus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-L-Arg-2-naphthylamide + H2O
-
Capra hircus N-benzoyl-L-Arg + 2-naphthylamine
-
?

Synonyms

Synonyms Comment Organism
cathepsin B
-
Capra hircus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Capra hircus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6
-
assay at Capra hircus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000011
-
N-formyl-5-(3-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000113
-
N-formyl-5-(4-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000141
-
N-formyl-5-(2-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000146
-
N-formyl-5-(3-chlorophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000018
-
N-formyl-5-(2-chlorophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000211
-
N-formyl-5-(4-chlorophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000227
-
N-formyl-3,5-diphenylpyrazoline pH 6, 37°C Capra hircus
0.0000448
-
N-formyl-5-(4-methoxyphenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000455
-
N-formyl-5-(3-methoxyphenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.0000668
-
N-formyl-5-(2-methoxyphenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000195
-
N-benzoyl-5-(3-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000287
-
N-benzoyl-5-(4-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000572
-
N-benzoyl-5-(2-nitrophenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000677
-
N-benzoyl-5-(3-chloro phenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000775
-
N-benzoyl-5-(2-chloro phenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.000925
-
N-benzoyl-5-(4-chloro phenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.00115
-
N-benzoyl-3,5-diphenylpyrazoline pH 6, 37°C Capra hircus
0.001277
-
N-benzoyl-5-(4-methoxy phenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.001594
-
N-benzoyl-5-(3-methoxy phenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus
0.004901
-
N-benzoyl-5-(2-methoxyphenyl)-3-phenylpyrazoline pH 6, 37°C Capra hircus