Literature summary for 3.4.22.1 extracted from

Kryczka, J.; Papiewska-Pajak, I.; Kowalska, M.A.; Boncela, J.
Cathepsin B is upregulated and mediates ECM degradation in dolon adenocarcinoma HT29 cells overexpressing snail (2019), Cells, 8, 203 .

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P07858	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
HT-29 cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	the enzyme is upregulated in colon adenocarcinoma HT29 cells overexpressing Snail (a key regulator of the extracellular matrix degradation)	up

General Information

General Information	Comment	Organism
physiological function	the enzyme is upregulated and mediates extracellular matrix degradation in colon adenocarcinoma HT29 cells overexpressing Snail (a key regulator of the extracellular matrix degradation). It is hypothesized that cathepsin B controls extracellular matrix proteolysis related to mesenchymal migration in colon cancer cells at early stages of the epithelial-to-mesenchymal transition	Homo sapiens

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Release 2023.1 (January 2023)