Literature summary for 3.4.22.1 extracted from

Que, X.; Ngo, H.; Lawton, J.; Gray, M.; Liu, Q.; Engel, J.; Brinen, L.; Ghosh, P.; Joiner, K.A.; Reed, S.L.
The cathepsin B of Toxoplasma gondii, toxopain-1, is critical for parasite invasion and rhoptry protein processing (2002), J. Biol. Chem., 277, 25791-25797.

Search for more literature for 3.4.22.1

Cloned(Commentary)

Cloned (Comment)	Organism
-	Toxoplasma gondii

Inhibitors

Inhibitors	Comment	Organism	Structure
PRT2005	commercial peptidyl ketone inhibitors, Prototek, 50% inhibition at less than 0.001 mM	Toxoplasma gondii
PRT2253	commercial peptidyl ketone inhibitors, Prototek, 50% inhibition at less than 0.001 mM	Toxoplasma gondii

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
rhoptry	secretory organelle	Toxoplasma gondii	20008	-

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
32400	-	x * 62200, preproenzyme, x * 32400, mature enzyme, calculated from amino acid sequence	Toxoplasma gondii
62200	-	x * 62200, preproenzyme, x * 32400, mature enzyme, calculated from amino acid sequence	Toxoplasma gondii

Organism

Organism	UniProt	Comment	Textmining
Toxoplasma gondii	-	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	sequence contains two putative glycosilation sites	Toxoplasma gondii
proteolytic modification	sequence contains a prepropeptide region	Toxoplasma gondii

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
pro-rhoptry protein 2 + H2O	-	Toxoplasma gondii	rhoptry protein 2 + propeptide	-	?

Subunits

Subunits	Comment	Organism
?	x * 62200, preproenzyme, x * 32400, mature enzyme, calculated from amino acid sequence	Toxoplasma gondii

Synonyms

Synonyms	Comment	Organism
toxopain-1	-	Toxoplasma gondii

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)