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Literature summary for 3.4.22.1 extracted from

  • Terada, K.; Yamada, J.; Hayashi, Y.; Wu, Z.; Uchiyama, Y.; Peters, C.; Nakanishi, H.
    Involvement of cathepsin B in the processing and secretion of interleukin-1beta in chromogranin A-stimulated microglia (2010), Glia, 58, 114-124.
    View publication on PubMed
Search for more literature for 3.4.22.1

Protein Variants

Protein Variants Comment Organism
additional information cathepsin B deficiency inhibits pro-interleukin-1beta processing and maturation in microglia, no observable expression of the cleaved IL-1beta in the hippocampus of the aged CB-/- mice Mus musculus

Inhibitors

Inhibitors Comment Organism Structure
CA-074-Me a specific inhibitor, inhibits pro-interleukin-1beta processing in microglia Mus musculus
E-64 a broad cysteine protease inhibitor Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
 Mus musculus 5764
-
additional information subcellular localization study, overview Mus musculus
-
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE Mus musculus
29000
-
 x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 C57/Bl mice
-
Mus musculus C57/Bl
-
 C57/Bl mice
-

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
 Mus musculus
-
microglia isolated from the mixed primary cell cultures from the cerebral cortex of 3-day-old wild-type or CB-/- mice, activated by chromogranin A Mus musculus
-

Subunits

Subunits Comment Organism
? x * 29000, mature cathepsin B, single-chain form, SDS-PAGE, x * 26000, mature cathepsin B, heavy-chain, SDS-PAGE Mus musculus

Expression

Organism Comment Expression
Mus musculus chromogranin A markedly induces cathepsin B at both protein and mRNA levels, determined by real-time quantitative RT-PCR up

General Information

General Information Comment Organism
physiological function cathepsin B is required for interleukin-1beta maturation, the maturation of pro-IL-1beta in chromogranin A-stimulated microglia is dependent on the enzymatic activities of both cathepsin B and caspase-1 Mus musculus