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3.4.22.1: cathepsin B

This is an abbreviated version!
For detailed information about cathepsin B, go to the full flat file.

Word Map on EC 3.4.22.1

Reaction

Hydrolysis of proteins with broad specificity for peptide bonds. Preferentially cleaves -Arg-Arg-/- bonds in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides =

Synonyms

AC-5, AC-cathB-1, AC-cathB-2, APP secretase, cat B, CatB, CatB1, Cath B, Cath-B, CathB, cathepsin B, cathepsin B proteinase, cathepsin B-like AC-5, cathepsin B-like counter-defence protein, cathepsin B-like cysteine protease, cathepsin B-like cysteine protease 1, cathepsin B-type cysteine protease, cathepsin B1, cathepsin B2, cathepsin B5, cathepsin Ba, cathepsin II, cathepsin-B, CmCatB1, CmCatB2, CP-2, CPB, CpCathB, CPR-4, CsCB1, CsCB2, CsCB3, CsCB4, CTB, CTSB, cysteine cathepsin, DEVDase, LycCatB, MmeCB, More, Na-CP-2, Na-CP-3, Na-CP-4, Na-CP-5, NbCathB, nfcpb, nfcpb-L, PcCTSB, rFgCatB2, Sm31, SmCatB, SmCB1, toxopain-1, TrCB1.1, TrCB1.2, TrCB1.3, TrCB1.4, TrCB1.5, TrCB1.6, TsCPB2

ECTree

     3 Hydrolases
         3.4 Acting on peptide bonds (peptidases)
             3.4.22 Cysteine endopeptidases
                3.4.22.1 cathepsin B

KCat KM Value

KCat KM Value on EC 3.4.22.1 - cathepsin B

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kcat/KM VALUE [1/mMs-1]
SUBSTRATE
ORGANISM
UNIPROT
COMMENTARY hide
LITERATURE
IMAGE
2037
Abz-FRF(NO2)A
37°C, pH 4.5
116
Abz-GIVRAK-Dnp
37°C, pH 4.5
111
benzyloxycarbonyl-Arg-Arg-7-amido-4-methylcoumarin
37°C, pH 4.5
5.38 - 17.86
benzyloxycarbonyl-L-leucyl-L-arginine-4-methylcoumaryl-7-amide
4.82 - 13.31
benzyloxycarbonyl-L-phenylalaninyl-L-arginine 4-methylcoumaryl-7-amide
98
benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin
37°C, pH 4.5
0.244
Boc-Asp-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
1.976
Boc-Asp-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
2.2
Boc-Val-Leu-Lys-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
1.346
Boc-Val-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
0.032
D-Val-Leu-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
3.87
N,N'-diBoc-dityrosine-Gly-(isoniazid)2
pH 6.2, 25°C
1.8
N,N'-diBoc-dityrosine-Lys-(isoniazid)2
pH 6.2, 25°C
10.54
N-benzyloxycarbonyl-Arg-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
1.293
N-benzyloxycarbonyl-Arg-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
36.59
N-benzyloxycarbonyl-Phe-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
1.046
N-benzyloxycarbonyl-Phe-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
7.104
N-benzyloxycarbonyl-Val-Ile-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
45.4
Nalpha-carbobenzoxy-L-Arg-L-Arg-7-amido-4-trifluoromethylcoumarin
recombinant enzyme, at pH 7.3 and 37°C
2.56
Tos-Gly-Pro-Arg-4-methyl-7-amidocoumarin
-
pH 6.0, 22°C
2.227
Tos-Gly-Pro-Arg-4-methylcoumarin 7-amide
-
pH 6.0, 22°C
additional information
Abz-Ala-Phe-Arg-Ser-Ala-X-Gln-EDDnp